Health of greenspace workers: Morbidity and mortality data from the AGRICAN cohort

Graaf, Lucie De; Talibov, Madar; Boulanger, Mathilde; Bureau, Mathilde; Robelot, Elsa; Lebailly, Pierre; Baldi, Isabelle

doi:10.1016/j.envres.2022.113375

Cited by 4 publications

(4 citation statements)

References 67 publications

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“…It is important to highlight that pesticides, including those reported here in our study area, are pointed out as endocrine disruptors (43-46), an event intrinsically linked to deregulated immunological and inflammatory responses (9) that could confer some carcinogenic potential to such substances. Our findings strengthen several worldwide studies demonstrating augmented breast cancer risk in pesticide occupationally exposed women (47)(48)(49)(50)(51)(52)(53)(54)(55) by adding information about possibly implicated mechanisms in the pre-carcinogenic stages. Detecting pesticides in urine, blood, breast milk, and mammary tissue samples from exposed women reinforces the idea that they may have a systemic impact (14,(56)(57)(58).…”

Section: Discussionsupporting

confidence: 86%

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

da Silva,

Ferreira,

Komori

et al. 2023

Front. Public Health

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Studies have documented the high occurrence of several tumors, including female breast cancer, in populations occupationally exposed to pesticides worldwide. It is believed that in addition to direct DNA damage, other molecular alterations that indicate genomic instability are associated, such as epigenetic modifications and the production of inflammation mediators. The present study characterized the profile of inflammatory changes in the breast tissue of women without cancer occupationally exposed to pesticides. In samples of normal breast tissue collected during biopsy and evaluated as negative for cancer by a pathologist, oxidative stress levels were assessed as inflammatory markers through measurements of lipoperoxides and total antioxidant capacity of the sample (TRAP) by high-sensitivity chemiluminescence, as well as levels of nitric oxide (NOx) metabolites. The levels of inflammation-modulating transcription factors PPAR-γ (peroxisome proliferator-activated receptor gamma) and NF-κB (nuclear factor kappa B) were also quantified, in addition to the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin 12 (IL-12). The levels of lipoperoxides, TRAP, and NOx were significantly lower in the exposed group. On the other hand, PPAR-γ levels were increased in the breast tissue of exposed women, with no variation in NF-κB. There was also a rise of TNF-α in exposed women samples without significant variations in IL-12 levels. These findings suggest an inflammatory signature of the breast tissue associated with pesticide exposure, which may trigger mechanisms related to mutations and breast carcinogenesis.

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Section: Discussionsupporting

confidence: 86%

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

da Silva,

Ferreira,

Komori

et al. 2023

Front. Public Health

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“…Pesticides may pose a substantial risk for BC development. Current evidence is based, for instance, on case-control studies characterizing female environmental contact with organochlorines. − Risk assessment studies about occasional pesticide exposure and BC development have also shown a positive association in multiple populations, with hazard risks reaching more than 4 times in some cases but not others. ,,,,,, This variability may result from various factors, such as epidemiological studies that analyze the overall population with individuals who are occasionally/accidentally exposed to pesticides versus target populations with high exposure, such as rural workers. The pesticide residues found in the present study were very similar to others identified in surveys of urine samples in populations worldwide.…”

Section: Discussionmentioning

confidence: 99%

“…Human exposure to pesticides has been linked to age-associated diseases, such as cancer, − particularly for chronically exposed rural workers. − Cancers of the thyroid, skin, kidneys, lymph nodes, larynge, lung, colon, and prostate have been reported to have a significantly higher incidence in pesticide-spraying farmers.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil

Panis,

Candiotto,

Gaboardi

et al. 2024

Environ. Sci. Technol.

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Rural workers are disproportionally exposed to pesticides and might be at an increased risk of developing chronic diseases. Here, we investigated the impact of pesticide exposure on breast cancer (BC) risk and disease profile in rural female workers. This is a case-control study that prospectively included 758 individuals. The study was conducted in the Southwest region of Paranástate in Brazil, a region characterized by familybased agriculture and intensive use of pesticides. We found that this region has a 41% higher BC diagnosis rate and 14% higher BC mortality rate than the mean rates in Brazil, as well as a pesticide trade volume about 6 times higher than the national average. We showed substantial exposure in this population and found that even women who did not work in the fields but performed equipment decontamination and clothes washing of male partners who worked in the fields had urine samples positive for glyphosate, atrazine, and/or 2,4-D. The crude association showed a significantly higher risk of BC among women exposed to pesticides (OR: 1.58, 95% CI 1.18−2.13). Adjusted analyses showed a lower and nonstatistically significant association (OR: 1.30, 95% CI 41 0.87−1.95). Stratification on disease profile showed a significantly higher risk of lymph node metastasis (adjusted OR: 2.19, 95% CI 1.31−3.72) in women exposed to pesticides. Our findings suggest that female populations exposed to pesticides are at a higher risk of developing BC with a more aggressive profile and draw attention to the need to monitor rural populations potentially exposed to pesticides in the field or at home.

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“…Scaling this up, leads to an estimate of 385 million cases of pesticide poisoning annually world-wide [1]. Occupational exposures and work-related contact with pesticides account for 70% of the mortalities, and chronic exposure is associated with a group of syndromes, including numerous tumors and nervous system disorders [2]. Insecticides mostly target the nervous system including the acetylcholine receptor (e.g., a target for neonicotinoids) and acetylcholinesterase, an enzyme which plays an important role in the mediation of nerve impulses [3].…”

Section: Introductionmentioning

confidence: 99%

Remediation of Water Using a Nanofabricated Cellulose Membrane Embedded with Silver Nanoparticles

et al. 2022

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The removal of pesticide pollution is imperative, because of their high environmental load and persistence, and their potential for bioaccumulation in, and toxicity to the environment. Most pesticides are found to be toxic even at trace levels. AgNPs can be effectively used for the adsorption of pesticides, and the incorporation of the AgNPs onto a support polymeric membrane enhances their effectiveness and reduces the potential unwanted consequences of intentionally adding free nanoparticles to the environment. Here, silver nanoparticles (AgNPs) were synthesized using a reliable, eco-friendly, and one-step “green” method, by reacting Mentha Piperita (mint) extract with AgNO3 aqueous solution at 60°C in a microwave. The resulting high surface area nanoparticles are both economic and effective environmental remediation agents, playing a promising role in the elimination of aquatic pesticide pollution. Embedding the nanoparticles into a cellulose membrane at a low concentration (0.1 g) of AgNPs was shown to result in effectively adsorption of representative pesticides (Cypermethrin, Paraquat, and Cartap) within 60 min, while increasing the concentration of nanoparticles incorporated into the membrane further enhanced the removal of the exemplar pesticides from water. The high adsorption capacity makes the cellulose-AgNPs membrane an excellent substrate for the remediation of pesticide-polluted water.

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Health of greenspace workers: Morbidity and mortality data from the AGRICAN cohort

Cited by 4 publications

References 67 publications

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

Brief research report pesticide occupational exposure leads to significant inflammatory changes in normal mammary breast tissue

Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil

Remediation of Water Using a Nanofabricated Cellulose Membrane Embedded with Silver Nanoparticles

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