Health Measures Correlates in a French Elderly Community Population: The Paquid Study

Barberger‐Gateau, Pascale; Chaslerie, Anicet; Dartigues, J.-F.; Commenges, Daniel; Gagnon, Marc‐André; Salamon, Roger

doi:10.1093/geronj/47.2.s88

Cited by 119 publications

(65 citation statements)

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“…All individuals were screened with the Mini Mental State Examination (MMSE), [27]), Lawton's Instrumental Activities of Daily Living (IADL, [28]) and the Hospital Anxiety and Depression Scale (HAD, [29]). In addition, extensive neuropsychological testing was performed, including attention (Code, [30], Trail Making Test A, [31]), working memory (verbal: Digit Span Forward [32], visuo-spatial: Corsi Block Tapping [33]), episodic memory (verbal: Buschke Double Memory 48 items [34], visual: Shapes test [35]), executive functions (Trail Making Test B [36], verbal fluency [37], Wisconsin card sorting [38]), language (Boston Naming, [39]), visual gnosis (Ghent Overlapping Figures, [40]) and praxis (ideomotor, reflexive and constructional [41]).…”

Section: Methodsmentioning

confidence: 99%

Attention-Related Potentials Allow for a Highly Accurate Discrimination of Mild Cognitive Impairment Subtypes

Missonnier

Herrmann²,

Richiardi³

et al. 2012

Neurodegener Dis

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The three most frequent forms of mild cognitive impairment (MCI) are single-domain amnestic MCI (sd-aMCI), single-domain dysexecutive MCI (sd-dMCI) and multiple-domain amnestic MCI (md-aMCI). Brain imaging differences among single domain subgroups of MCI were recently reported supporting the idea that electroencephalography (EEG) functional hallmarks can be used to differentiate these subgroups. We performed event-related potential (ERP) measures and independent component analysis in 18 sd-aMCI, 13 sd-dMCI and 35 md-aMCI cases during the successful performance of the Attentional Network Test. Sensitivity and specificity analyses of ERP for the discrimination of MCI subgroups were also made. In center-cue and spatial-cue warning stimuli, contingent negative variation (CNV) was elicited in all MCI subgroups. Two independent components (ICA1 and 2) were superimposed in the time range on the CNV. The ICA2 was strongly reduced in sd-dMCI compared to sd-aMCI and md-aMCI (4.3 vs. 7.5% and 10.9% of the CNV component). The parietal P300 ERP latency increased significantly in sd-dMCI compared to md-aMCI and sd-aMCI for both congruent and incongruent conditions. This latency for incongruent targets allowed for a highly accurate separation of sd-dMCI from both sd-aMCI and md-aMCI with correct classification rates of 90 and 81%, respectively. This EEG parameter alone performed much better than neuropsychological testing in distinguishing sd-dMCI from md-aMCI. Our data reveal qualitative changes in the composition of the neural generators of CNV in sd-dMCI. In addition, they document an increased latency of the executive P300 component that may represent a highly accurate hallmark for the discrimination of this MCI subgroup in routine clinical settings.

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Section: Methodsmentioning

confidence: 99%

Attention-Related Potentials Allow for a Highly Accurate Discrimination of Mild Cognitive Impairment Subtypes

Missonnier

Herrmann²,

Richiardi³

et al. 2012

Neurodegener Dis

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“…Three criteria had to be met for subjects to be included in the study: (i) to be at least 65 years of age on December 31, 1987; (ii) to live at home at the time of the initial data collection; and (iii) to be included on the communal (local) electoral lists. The general methodology of PAQUID has been described elsewhere (29). In brief, in 1988, all subjects were interviewed for one and one-half hours at home by a trained psychologist.…”

Section: Methodsmentioning

confidence: 99%

“…In this work, referring to the first strategy, we measured the baseline DHEA(S) levels in the serum of individuals more than 65 years of age, studied for Ϸ5 years in the PAQUID** program, a longitudinal community-based study of the elderly (29) designed to investigate possible correlations with functional, psychological, and mental status, and therefore to see if the results are consistent with the preliminary reported effects of replacement doses of administered DHEA. Furthermore, after 2-and 4-year follow-ups, we could also assess incident dementia and mortality.…”

mentioning

confidence: 99%

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

Berr

Lafont

Debuire

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

256

128

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In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward Ϸ20-10% of its value in young adults during the 8th and 9th decades. The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor I, and effects on neurotransmitter receptors. Whether there is a cause-to-effect relationship between the decreasing levels of DHEAS with age and physiological and pathological manifestations of aging is still undecided, but this is of obvious theoretical and practical interest in view of the easy restoration by DHEA administration. Here we report on 622 subjects over 65 years of age, studied for the 4 years since DHEAS baseline values had been obtained, in the frame of the PAQUID program, analyzing the functional, psychological, and mental status of a communitybased population in the south-west of France. We confirm the continuing decrease of DHEAS serum concentration with age, more in men than in women, even if men retain higher levels. Significantly lower values of baseline DHEAS were recorded in women in cases of functional limitation (Instrumental Activities of Daily Living), confinement, dyspnea, depressive symptomatology, poor subjective perception of health and life satisfaction, and usage of various medications. In men, there was a trend for the same correlations, even though not statistically significant in most categories. No differences in DHEAS levels were found in cases of incident dementia in the following 4 years. In men (but not in women), lower DHEAS was significantly associated with increased short-term mortality at 2 and 4 years after baseline measurement. These results, statistically established by taking into account corrections for age, sex, and health indicators, suggest the need for further careful trials of the administration of replacement doses of DHEA in aging humans. Indeed, the first noted results of such ''treatment'' are consistent with correlations observed here between functional and psychological status and endogenous steroid serum concentrations.

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“…For inclusion in the study, the subjects had to meet three criteria: to be registered on the local electoral lists, to be at least 65 years of age on December 31, 1987, and to be living at home. The general Paquid methodology has been described elsewhere [34]. Briefly, in 1988, all the subjects underwent a 90-min interview at home by a trained psychologist.…”

Section: Study Populationmentioning

confidence: 99%

Plasma Insulin-Like Growth Factor I Levels in the Elderly: Relation to Plasma Dehydroepiandrosterone Sulfate Levels, Nutritional Status, Health and Mortality

et al. 2001

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Background: Insulin-like growth factor I (IGF-I) has beneficial metabolic effects. Because plasma IGF-I levels have been reported to be enhanced by dehydroepiandrosterone (DHEA) administration, it has been suggested that the IGF-I may be implicated in some of the reported associations between low DHEA sulfate (DHEAS) levels and impaired health measures in elderly subjects. The nutritional status, which also regulates plasma IGF-I levels, is also an important determinant of health outcome. Objective: We sought to investigate the associations between plasma IGF-I levels and plasma DHEAS levels, nutritional status, health, and mortality in the elderly. Methods: In 256 community-dwelling subjects aged 65–101 years, enrolled in the Paquid study, a health questionnaire was used to acertain their functional disabilities, any history of medical disorders, self-perceived health, depressive symptoms, and their cognitive function. Biological measurements included levels of plasma IGF-I, albumin, transthyretin, and DHEAS. Mortality data were available for 6 years following blood sampling. Results: In this elderly population with no impairment in nutritional status, the plasma IGF-I levels decreased significantly with age (p = 0.02). The plasma IGF-I levels correlated positively with those of transthyretin (p = 0.0001). IGF-I also correlated with DHEAS (p = 0.04), but the correlation did not remain significant after adjustment for age. As opposed to SDHEA, the plasma IGF-I levels did not correlate with the results from the health questionnaire. The baseline IGF-I values in the highest tertile were associated with a higher risk of short-term mortality than those in the lowest tertile (RR = 8.4 at 2 years, p = 0.007). Conclusions: Our results suggest that IGF-I is not connected with the association between low plasma DHEAS levels and the impaired results from the health questionnaire. The relationship between plasma IGF-I highest levels and mortality should be further explored.

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Health Measures Correlates in a French Elderly Community Population: The Paquid Study

Cited by 119 publications

References 0 publications

Attention-Related Potentials Allow for a Highly Accurate Discrimination of Mild Cognitive Impairment Subtypes

Attention-Related Potentials Allow for a Highly Accurate Discrimination of Mild Cognitive Impairment Subtypes

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

Plasma Insulin-Like Growth Factor I Levels in the Elderly: Relation to Plasma Dehydroepiandrosterone Sulfate Levels, Nutritional Status, Health and Mortality

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