Health Information Management for Research and Quality Assurance: The Comprehensive Renal Transplant Research Information System

Famure, Olusegun; Phan, Nicholas; Kim, Sang Joseph

doi:10.1016/j.hcmf.2013.11.002

Cited by 33 publications

(32 citation statements)

References 10 publications

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“…These data have been abstracted from patient charts (electronic and paper), entered into the database, and audited for completeness and accuracy. 34 Immunosuppression All recipients universally received either depleting or non-depleting induction therapy. Maintenance immunosuppression included a calcineurin inhibitor, mycophenolate mofetil, and prednisone.…”

Section: Data Sourcesmentioning

confidence: 99%

Delayed graft function and the risk of acute rejection in the modern era of kidney transplantation

Famure

et al. 2015

Kidney International

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Delayed graft function (DGF) is commonly considered a risk factor for acute rejection, although this finding has not been uniformly observed across all studies. The link between DGF and acute rejection may have changed over time due to advances in immunosuppression and medical management. Here we conducted a cohort study of 645 patients over 12 years to evaluate the association of DGF and biopsy-proven acute rejection (BPAR) in a modern cohort of kidney transplant recipients. DGF was defined as the need for at least one dialysis session in the first week after kidney transplantation. The 1-, 3-, and 5-year cumulative probabilities of BPAR were 16.0, 21.8, and 22.6% in the DGF group, significantly different from the 10.1, 12.4, and 15.7% in the non-DGF group. In multivariable Cox proportional hazards model, the adjusted relative hazard for BPAR in DGF (vs. no DGF) was 1.55 (95% confidence interval (CI): 1.03, 2.32). This association was generally robust to different definitions of DGF. The relative hazard was also similarly elevated for T-cell- or antibody-mediated BPAR (1.52 (0.92, 2.51) and 1.54 (0.85, 2.77), respectively). Finally, the association was consistent across clinically relevant subgroups. Thus DGF remains an important risk factor for BPAR in a contemporary cohort of kidney transplant recipients. Interventions to reduce the risk of DGF and/or its aftereffects remain of paramount importance to improve kidney transplant outcomes.

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Section: Data Sourcesmentioning

confidence: 99%

Delayed graft function and the risk of acute rejection in the modern era of kidney transplantation

Famure

et al. 2015

Kidney International

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178

143

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“…The data collected for this study were audited and merged with our in‐center research database, the Comprehensive Renal Transplant Research Information System (CoReTRIS) . CoReTRIS contains recipient, donor, transplant, laboratory, pathology, treatment, and follow‐up data for all patients who received a KT at our center since the year 2000.…”

Section: Methodsmentioning

confidence: 99%

Ethnic background is associated with no live kidney donor identified at the time of first transplant assessment—an opportunity missed? A single‐center retrospective cohort study

et al. 2019

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Summary Patients from ethnocultural minorities have reduced access to live donor kidney transplant (LDKT). To explore early pretransplant ethnocultural disparities in LDKT readiness, and the impact of the interactions with the transplant program, we assessed if patients had a potential live donor (LD) identified at first pretransplant assessment, and if patients with no LD initially received LDKT subsequently. Single‐center, retrospective cohort of adults referred for kidney transplant (KT) assessment. Multivariable logistic regression assessed the association between ethnicity and having a potential LD. Cox proportional hazard analysis assessed the association between no potential LD initially and subsequent LDKT. Of 1617 participants, 66% of Caucasians indicated having a potential LD, compared with 55% of South Asians, 44% of African Canadians, and 41% of East Asians (P < 0.001). In multivariable logistic regression analysis, the odds of having a potential LD identified was significantly lower for African, East and South Asian Canadians. No potential LD at initial KT assessment was associated with lower likelihood of LDKT subsequently (hazard ratio [HR], 0.14; [0.10–0.19]). Compared to Caucasians, African, East and South Asian and African Canadians are less likely to have a potential LD identified at first KT assessment, which predicts a lower likelihood of subsequent LDKT.

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“…38 The time origin for all analyses was set as the date of referral to the transplant center. The decision, the date of the decision, the date of all transplants, and the date of deaths were recorded in OTTR.…”

Section: Patient Follow-upmentioning

confidence: 99%

“…Specifically, they reviewed the medical documen- After appropriate quality checks, the data collected in this study were merged with our in-center research database, the Comprehensive Renal Transplant Research Information System (CoReTRIS). 38 CoReTRIS contains recipient, donor, transplant, laboratory, pathology, treatment, and follow-up data for all patients who received KT at the Toronto General Hospital since January 1,…”

Section: Data Sources and Managementmentioning

confidence: 99%

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Substance use in kidney transplant candidates and its impact on access to kidney transplantation

Tang

Bansal

Famure

et al. 2019

Clinical Transplantation

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Background Due to the increasing public acceptance of substance use, it is important to understand the association between substance use and access to kidney transplant and its outcomes. Here, we assess the sociodemographic predictors of substance use and the association between substance use and KT access. Methods Predictors of substance use were examined using a multivariable‐adjusted multinomial logistic regression. The association between current substance use (tobacco and drug) and time from referral to listing or receipt of a KT was examined using Cox proportional hazards models. Results Of 2346 patients, the prevalence of current substance use was 17%. Predictors of current tobacco use were younger age, male sex, Caucasian ethnicity, being unemployed, and unmarried. Predictors of current drug use were younger age, male sex, Caucasian ethnicity, a history of non‐adherence, and a history of mental health disorder. Patients with tobacco use had a decreased likelihood of being cleared for KT (hazard ratio [HR]:0.83[0.70, 0.99]) and receiving a KT (HR:0.80 [0.66, 0.96]). No association was seen in this sample for patients with drug use (HR:0.88 [0.69, 1.11] for being cleared for KT and 0.88 [0.69, 1.14] for KT, respectively). Conclusions Tobacco use was associated with a decreased likelihood of access to KT whereas there was no statistically significant difference in access to KT between patients with or without drug use.

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Health Information Management for Research and Quality Assurance: The Comprehensive Renal Transplant Research Information System

Cited by 33 publications

References 10 publications

Delayed graft function and the risk of acute rejection in the modern era of kidney transplantation

Delayed graft function and the risk of acute rejection in the modern era of kidney transplantation

Ethnic background is associated with no live kidney donor identified at the time of first transplant assessment—an opportunity missed? A single‐center retrospective cohort study

Substance use in kidney transplant candidates and its impact on access to kidney transplantation

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