Health functionality of apigenin: A review

Ali, Fahad; Rahul, .; Naz, Falaq; Jyoti, Smita; Siddique, Yasir Hasan

doi:10.1080/10942912.2016.1207188

Cited by 217 publications

(144 citation statements)

References 281 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…We further evaluated the effect of apigenin on RBC membrane integrity and did not observe noticeable signs of membrane disruption at the range of IC 50 values of this compound for the Plasmodium strains. All the toxicity assays in this study confirmed the health safety of apigenin that has been reported in earlier studies (Ali, Rahul, Naz, Jyoti, & Siddique, ; Nijveldt et al, ; Sampson, Rimm, Hollman, VRIES, & Katan, ; Shukla & Gupta, ). For further analysis of the in vivo toxicity of apigenin, we applied the metabolomics approach for finding the critical pathways affected by apigenin in mice.…”

Section: Discussionsupporting

confidence: 89%

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice

Amiri

Nourian

Khoshkam

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

Due to the challenges in the control, prevention, and eradication of parasitic diseases like malaria, there is an urgent need to discover new therapeutic agents. Plant-derived medicines may open new ways in the field of antiplasmodial therapy. This study is aimed to investigate the toxicity and in vivo antiplasmodial activity of apigenin, a dietary flavonoid. Apigenin cytotoxicity was investigated on Huh7 cell line, brine shrimp (Artemia salina) larva, and human red blood cells. In vivo toxicity of apigenin was assessed by metabolomics approaches. Apigenin exhibited significant suppression of parasitemia in a dose-dependent manner; it suppressed Plasmodium berghei growth by 69.74%, 50.3%, and 49.23% at concentrations of 70, 35, and 15 mg/kg/day, respectively. The IC value for apigenin after 24 hr exposure to Huh7 cells was 225 μg/ml. Apigenin did not show noticeable toxicity on A. salina and also on the membrane integrity of red blood cells. After 24 hr exposure of mice to apigenin, alterations were seen in the metabolism of glucocorticoids and mineralocorticoids, bile acid metabolism (alternative pathway), sulfur metabolism, bile acid metabolism, metabolism of estrogens and androgens, cholesterol catabolism, and biosynthesis of cholesterol. These findings indicate that apigenin has potential in vivo antiplasmodial activity against P. berghei infected mice with high selectivity against malaria, but it can disrupt some metabolic pathways in mice.

show abstract

Section: Discussionsupporting

confidence: 89%

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice

Amiri

Nourian

Khoshkam

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Flavones are found in vegetables and fruits like onions, parsley, wheat sprouts, tea, oranges, broccoli, celery, carrots, parsley, onion, cabbages, pepper, apple, chamomile, and some spices (26,27). Apigenin (4′, 5, 7-trihydroxyflavone) is a primary component of chamomile, which found in parsley, celery, onions, oranges, maize, rice, tea, and wheat sprouts (26). Apigenin has been shown potential strong therapeutic effects against various diseases.…”

Section: Flavonesmentioning

confidence: 99%

“…Apigenin shows anti-atherosclerotic effect by preventing LDL oxidation. Apigenin has been showed anti-inflammatory properties by reducing the expression of COX-2, IL-8, and tumor necrosis factor alpha (TNF-α) in vitro (26). It also inhibits mitogen-activated protein kinase (MAPK) phosphorylation.…”

Section: Flavonesmentioning

confidence: 99%

See 1 more Smart Citation

Flavonoids in Our Foods: A Short Review

Guven

Arıcı

Simsek

2019

J Basic Clin Health Sci

View full text Add to dashboard Cite

The aerobic metabolism in biological systems, produces reactive oxygen species (ROS) known as prooxidants even in basal conditions. If the formation of prooxidants increases, it leads to oxidative stress/damage. Various diseases in humans (cancer, chronic diseases, cardiovascular problems etc.) accompanies with prooxidant damage. Endogenous and exogenous antioxidants protect biomolecules against the damage of prooxidants. Flavonoids are potent antioxidant molecules, which scavenge free radicals in vitro. They are found in fruits, vegetables, bark, roots, flowers and certain beverages. It has been reported that these natural products produce a wide variety of biological effects, like antiviral, anti-allergic, anti-inflammatory, anti-carcinogenic, antidiabetic effects. Flavonoids are important for human diet and have beneficial effects on health like chelating trace elements involved in free radical production, scavenging ROS and upregulating or protecting antioxidant defenses. In addition, they have known to modulate different cytochrome P450 enzymes such as CYP1A1/1A2, CYP1B1, CYP2C9, and CYP3A4/3A5. Flavonoids and their metabolites in organism may cause flavonoid-drug interaction, and it may lead to toxicity of drug or inefficient therapeutic effects of drug. However, knowledge on the mechanisms of action of flavonoids is still not fully understood. The information about correlation of structurebiological effect is limited. There are six major subclasses of flavonoids are flavanols, flavanones, flavonols, flavones, anthocyanidins, and isoflavones. This review summarizes the types of flavonoids, possible mechanisms of action and pharmacokinetic specialties, bioavailability, properties and drug interactions of these flavonoids.

show abstract

“…Apigenin also led to a reversal of epithelial-mesenchymal transition (EMT) and G2/M phase arrest (Zhu et al, 2015). It is reported that apigenin extracted in the form of apigenin 7-O-β-D-glucopyranoside and apigenin 7-Oβ-D-(4′caffeoyl) glucuronide from two medicinal herbs Kummerowia striata and Chrysanthemum morifolium, respectively, have shown anti-HIV activity (Ali et al, 2017;Lee et al, 2003;Tang et al, 1994). Apigenin is also reported to have various other health effects such as antioxidant, anti-inflammatory, blood pressure regulation, antibacterial, and plethora of pharmacological activities against auto-immune disorders, rheumatoid arthritis, multiple sclerosis, Parkinson's disease and Alzheimer's disease (Ali et al, 2017;Yan et al, 2017).…”

Section: Apigeninmentioning

confidence: 99%

Bioavailability and Metabolism of Food Bioactives and their Health Effects: A Review

Shahidi¹,

Ramakrishnam²,

Oh³

2019

JFB

View full text Add to dashboard Cite

Numerous studies have demonstrated the availability of high-quality bioactive compounds in food along with their determination and quantification techniques. Many of these identified compounds have been claimed to possess health benefits such as anti-inflammatory, anti-cancer, antioxidant, anti-allergic, anti-fungal, antimicrobial and cardioprotective spasmolytic properties. However, mere presence of these compounds does not directly correlate with their potential health effects upon consumption. Since any food consumed does not reach the blood stream in the original form and as they are broken down to various compounds it is mandatory to consider their bioavailability and metabolism that takes place upon absorption. Furthermore, the efficacy of these bioactive compounds depends on various factors including the dosage, food matrix and stability of the compound during metabolism. Various bioavailability studies indicate that the parent bioactive compound is broken into various metabolites via oxidation, dehydroxylation, de-esterification, hydrolysis, carboxylation, α- and β-oxidation processes inside the human body. Therefore, this leads to an interesting conundrum that whether the proposed health effects are due to the parent bioactive compound or due to the metabolites formed during absorption. Some details in relation to the metabolism and metabolites of food bioactives are presented in this contribution.

show abstract

Health functionality of apigenin: A review

Cited by 217 publications

References 281 publications

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice

Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice

Flavonoids in Our Foods: A Short Review

Bioavailability and Metabolism of Food Bioactives and their Health Effects: A Review

Contact Info

Product

Resources

About