“…A number of investigations have looked into complex mixtures of VOCs to establish their ability to elicit nasal and/or ocular trigeminal chemesthesis in humans, at threshold and suprathreshold levels, among other diverse effects. Examples of such complex stimuli include: environmental tobacco smoke (Cain et al, 1987), fragranced products (Millqvist et al, 1999;Opiekun et al, 2003), indoor air (Hudnell et al, 1992;Laumbach et al, 2005;Meininghaus et al, 2003;Otto et al, 1990), and outdoor air surrounding composting facilities (Müller et al, 2004), animal production facilities (Schiffman et al, 2000;Schiffman and Williams, 2005), and other industries (Dahlgren et al, 2003). In such studies, the typical goal was to assess the effect of the mixture (diluted or neat) on different groups of subjects (e.g., unexposed controls, exposed subjects, asthmatics, etc.).…”