Health Effects Classification and Its Role in the Derivation of Minimal Risk Levels: Neurological Effects

Chou

2005

The Agency for Toxic Substances and Disease Registry (ATSDR) derives health based guidance values called minimal risk levels (MRLs) to assist with assessment of risks posed by exposures to hazardous chemicals. Current MRLs are posted on ATSDR's web site (www.atsdr.cdc.gov). From the total 326 MRLs currently posted, 79 MRLs are based on hepatic endpoints. The paper reports on endpoints used for the derivation of these MRLs and the use of uncertainty factors. It also describes the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles.

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Section: Introductionmentioning

confidence: 96%

Health effects classification and its role in the derivation of minimal risk levels: Hepatic effects

Chou

2005

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“…So far, the guidance has served as an internal document. However, parts of the guidance related to hematologic, neurologic, developmental, and respiratory end points and related MRLs were previously published (Abadin et al, 1998;Chou and Williams-Johnson, 1998;Pohl et al, 1998;Wilbur, 1998).…”

Section: Introductionmentioning

confidence: 96%

Health effects classification and its role in the derivation of minimal risk levels: Renal effects

Smith-Simon

Hicks

2005

“…So far, the guidance has served as an internal document and has not been released to the public. However, parts of the guidance related to neurological, developmental, and respiratory effects and respective MRLs based on these effects were previously published (Chou and Williams-Johnson, 1998;Pohl et al, 1998;Wilbur, 1998).…”

Section: Introductionmentioning

confidence: 97%

Health effects classification and its role in the derivation of minimal risk levels: Reproductive and endocrine effects

Luukinen²,

Holler

2005