Health effects and arsenic species in urine of copper smelter workers

Hałatek, Tadeusz; Sińczuk-Walczak, H; Janasik, Beata; Trzcinka-Ochocka, Małgorzata; Winnicka, Renata; Wąsowicz, Wojciech

doi:10.1080/10934529.2014.882207

Cited by 14 publications

(9 citation statements)

References 42 publications

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“…These early respiratory impairments are predisposing factors for asthma and COPD in adulthood [ 3 ], and may explain associations between arsenic exposure and chronic respiratory disease. Occupational arsenic exposure via air is also associated with decreased CC16 levels [ 23 , 24 ]. In Bangladesh, where arsenic exposures via drinking water are very high, adults without skin lesions but with reduced lung function had higher levels of arsenic exposure and lower levels of circulating CC16 [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media

Beamer

Klimecki

Loh

et al. 2016

IJERPH

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Arsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil (b = −0.43, p = 0.001, R2 = 0.08), water (b = −0.22, p = 0.07, R2 = 0.03), house dust (b = −0.37, p = 0.07, R2 = 0.04), and dust loading (b = −0.21, p = 0.04, R2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels (b = −0.42, p = 0.02, R2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.

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Section: Introductionmentioning

confidence: 99%

Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media

Beamer

Klimecki

Loh

et al. 2016

IJERPH

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“…That air pollution does indeed compromise kidney function is supported by the finding that glomerular filtration is compromised by breathing heavy metals from copper smelters and by living in close proximity to major roadways. 41,42 In addition, rats exposed to either the asbestos group member amosite or to passive smoking develop significant glomerulosclerosis and tubulinterstitial fibrosis, and occupational exposure to silica, fiberglass, or solvents has been linked to an increased risk of developing ESRD. 35,214 Atherosclerosis Approximately six million Americans have combined atherosclerosis and kidney disease.…”

Section: Air Pollutionmentioning

confidence: 99%

“…This in turn is driven by a constellation of interlinked risk factors. Primary amongst these factors are anemia, [6][7][8][9] diabetic hyperglycemia, [10][11][12] hypertension, [13][14][15][16][17] hypercholesterolemia, [18][19][20] cigarette smoking, [21][22][23][24][25][26][27] air pollution, [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] atherosclerosis, [43][44][45][46][47][48][49][50][51][52] repeated episodes of acute kidney injury, [53][54][55][56]…”

mentioning

confidence: 99%

Hypoxia: The Force that Drives Chronic Kidney Disease

Colgan

Shelley

2016

Clinical Medicine & Research

125

111

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In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the elderly are disproportionally high. Consequently, as life expectancy increases and the baby-boom generation reaches retirement age, the already heavy burden imposed by ESRD on the US health care system is set to increase dramatically. ESRD represents the terminal stage of chronic kidney disease (CKD). A large body of evidence indicating that CKD is driven by renal tissue hypoxia has led to the development of therapeutic strategies that increase kidney oxygenation and the contention that chronic hypoxia is the final common pathway to end-stage renal failure. Numerous studies have demonstrated that one of the most potent means by which hypoxic conditions within the kidney produce CKD is by inducing a sustained inflammatory attack by infiltrating leukocytes. Indispensable to this attack is the acquisition by leukocytes of an adhesive phenotype. It was thought that this process resulted exclusively from leukocytes responding to cytokines released from ischemic renal endothelium. However, recently it has been demonstrated that leukocytes also become activated independent of the hypoxic response of endothelial cells. It was found that this endothelium-independent mechanism involves leukocytes directly sensing hypoxia and responding by transcriptional induction of the genes that encode the β2-integrin family of adhesion molecules. This induction likely maintains the long-term inflammation by which hypoxia drives the pathogenesis of CKD. Consequently, targeting these transcriptional mechanisms would appear to represent a promising new therapeutic strategy.

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“…In occupational cohorts, arsenic exposure was associated with decreased serum CC16 and increased urinary β2-microglobulin, yet no significant differences in serum β2-microglobulin were reported [6,7]. Unfortunately, we did not have serum samples to measure CC16 for this population.…”

mentioning

confidence: 97%

“…Because others have demonstrated that decreased levels of CC16 are associated with increasing arsenic exposure [6,7,8], we sought to determine if this association persisted in children. We reported that decreased levels of urinary CC16 in children were most strongly associated with the concentration of arsenic in their soil and that this may demonstrate that localized arsenic exposure in the lungs could damage the airway epithelium [9].…”

mentioning

confidence: 99%