Health economics: A cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7

Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man

“…This compared with only 68.3 % D Gothard et al Tissue engineered bone and clinical translation to 85 % (Friedlaender et al, 2001) of patients who received autograft. These studies also reported decreased healing time (1.5 fold), hospital stay (3.4 fold) and treatment cost (1.9 fold) (Dahabreh et al, 2007;Ristiniemi et al, 2007). Taken together, current literature supports the application of BMP-7 within tissue engineering strategies for localised bone defect repair and regeneration.…”

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

“…Given the ineffective prior use of ABG alone (gold standard) in 44.4% of our series, the high number (average 2.3) of previous unsuccessful surgical interventions and the long period of incapability and its economic implications (median time before combined treatment plus median time to union was 26 months), the highly effective strategy of combined ABG and BMP-7 use could have potential economic benefits. Recent publications have identified the importance of this aspect of contemporary medicine as well as the lack of existing evidence regarding the financial burden of treating nonunions of fractures [13,28]. A gross comparison of the reported efficacy of ABG or BMP-7 of several published large series (Table 3) to our sample of the combined use of ABG and BMP-7 supports the existence of a potential synergism between recombinant human BMP-7 and ABG that may promote better healing rates in atrophic nonunions.…”

Osteogenic potency of human bone marrow mesenchymal stem cells from femoral atrophic non-union fracture site

“…These cases often require readmission and surgery, which exaggerate the cost greatly, with an estimate of £13 844.68 for a single case of non-union [1,2]. Besides the direct cost, the burden from the decreased productivity and quality of life also occurs, of which it costs $18 712 USD for one case [3].…”