Health Delivery and Quality Assurance Programs for Mice

Gaertner, Diane J.; Otto, G; Batchelder, Margaret

doi:10.1016/b978-012369454-6/50065-0

Cited by 2 publications

(1 citation statement)

References 40 publications

(30 reference statements)

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“…Some basic guidelines can ensure a minimum of standardization for sampling and testing. A number of general suggestions for establishing health monitoring programs have been published in the past few decades (Loew and Fox 1983;Small 1984;Nicklas 1996;NRC 1991), and textbooks provide useful information for the establishment of monitoring programs (e.g., Hansen 2000; Kunstyr and Nicklas 2000;Mähler and Nicklas 2004;Gaertner et al 2007).…”

Section: Harmonization Of Health Monitoringmentioning

confidence: 99%

International Harmonization of Health Monitoring

Nicklas¹

2008

ILAR Journal

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Proper health surveillance is vitally important to the evaluation of the microbial status of laboratory animals and the performance of standardized experiments with a minimum number of animals. Sufficient and reliable information about animals health status has become even more important during the last decade with the rapid development and worldwide exchange of new genetically modified rodents. But a universal testing strategy for the assessment of pathogen status in rodent populations and internationally recognized standards and definitions of their quality do not exist, even though health data can provide consistent information only when based on systematic sampling and testing. Although there have been repeated calls for the development of international health monitoring standards and reporting, there are also objections. This article presents both the advantages and limitations of guidelines. After an overview of major factors to consider I discuss previous attempts to harmonize health monitoring procedures. The health monitoring recommendations for rodents issued by the Federation of European Laboratory Science Associations (FELASA) could serve as a model for global recommendations and for international harmonization. Given the increased significance of accurate health information when exchanging animals, research institutions and universities would benefit from universal standards, which would also help scientists as well as reviewers and readers of publications to better assess the validity of research results.

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Section: Harmonization Of Health Monitoringmentioning

confidence: 99%

International Harmonization of Health Monitoring

Nicklas¹

2008

ILAR Journal

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A serological survey to evaluate contemporary prevalence of viral agents and Mycoplasma pulmonis in laboratory mice and rats in western Europe

Mähler

Köhl

2009

Lab Anim

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To evaluate current prevalence rates of 24 viruses and of the bacterium Mycoplasma pulmonis, the authors retrospectively surveyed serological data obtained from laboratory mice and rats housed in more than 100 western European institutions. Serum samples were submitted to the authors' institution for testing between January 2007 and June 2008. The prevalence of an infection was defined as the percentage of tested samples that yielded positive results for a specific agent. In mice, the most commonly detected infectious agents were murine norovirus (prevalence of 31.8%), mouse hepatitis virus (5.5%), mouse rotavirus (1.7%) and parvoviruses (1.0%). In rats, parvoviruses (12.1%) and M. pulmonis (3.6%) were the most prevalent infectious agents. Most rodent parvovirus infections could be attributed to mouse parvovirus in mice and to rat minute virus or to Kilham rat virus in rats. These data suggest the importance of up-to-date animal health monitoring programs and should stimulate the scientific community to further improve the microbiological quality of laboratory rodents.

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Health Delivery and Quality Assurance Programs for Mice

Cited by 2 publications

References 40 publications

International Harmonization of Health Monitoring

International Harmonization of Health Monitoring

A serological survey to evaluate contemporary prevalence of viral agents and Mycoplasma pulmonis in laboratory mice and rats in western Europe

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