Health care utilisation of infants with chronic lung disease, related to hospitalisation for RSV infection

Greenough, Anne; Cox, Sarah; Alexander, John R.; Lenney, Warren; Turnbull, F; Burgess, S; Chetcuti, Philip; Shaw, N J; Woods, A.E; Boorman, J; Coles, Stephen J.; Turner, Jackie

doi:10.1136/adc.85.6.463

Cited by 177 publications

(159 citation statements)

References 16 publications

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“…Preterm infants with BPD have an increased frequency of health care utilisation and hospital admissions due to acute respiratory infections compared to those without BPD [2,38,46]. Approximately, 50 to 73% of preterm infants with BPD were re-hospitalised at least once with an acute respiratory infection during the first 3 years of life, which is nearly twice the frequency of re-hospitalisation among those without BPD [7,47,48]. The risk of re-hospitalisation due to acute respiratory infection is significantly higher among infants with BPD who remain oxygen dependent after discharge during the first 3 years of life, compared to those who are not oxygen dependent at discharge (70% vs. 58% respectively; P < 0.001) [48].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…Four out of 10 (40%) of ICU admissions in our study were related to RSV infection. Greenough, et al in their retrospective review concluded that RSV hospitalization in patients with chronic lung disease is associated with increased ICU admission, and longer duration of ICU stay [6].…”

Section: Icu Admissionsmentioning

confidence: 99%

“…Re-hospitalization after initial discharge from NICU for preterm infants has been examined in various settings across the world [1][2][3][4][5][6][7][8][9][10][11][12][13]. Reasons for re-hospitalizations in extreme preterm infants can be related either to medical (bronchiolitis, lower-respiratory tract infection, asthma, reflux disease) or to surgical (PEG related problems, V-P shunt related issues, hernia repair) causes.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Hospital Readmission and Follow Up after NICU Discharge of Infants Born at Extremely Low Gestational Age in Metropolitan Melbourne

et al. 2017

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“…4 Up to 14% of all premature infants will be hospitalized with bronchiolitis early in life, and they will typically have a more severe course and a longer length of stay (LOS) than full term infants. [5][6][7] More than one-half of premature infants <29 weeks' gestational age may be admitted during infancy for respiratory distress, 8 and up to 1 in 4 patients <28 weeks' gestational age will exhibit moderate to severe respiratory dysfunction even at 2 years of age. 9 Furthermore, diminished lung function in premature infants has been associated with increased likelihood of severe illness.…”

Section: The Clinical Management Of Preterm Infants With Bronchiolitismentioning

confidence: 99%

The Clinical Management of Preterm Infants With Bronchiolitis

Alverson

McCulloh

Dawson-Hahn

et al. 2013

Hospital Pediatrics

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OBJECTIVES:The goal of this study was to determine physician management choices for hospitalized premature infants with bronchiolitis compared with term infants and to evaluate predictors of steroid use in premature infants. METHODS:A chart review was conducted of premature and nonpremature infants admitted to 2 children's hospitals with bronchiolitis. Reviewers selected charts based on International Classifi cation of Diseases, Ninth Revision diagnosis codes and collected demographic and historical information, as well as evaluation, treatment, treatment effectiveness, length of stay, hospital readmission rates, and adverse outcomes. Reviewers compared documented rates of utilization and effectiveness of inhaled racemic epinephrine and albuterol between patients with and without a history of prematurity. Patients with a history of prematurity underwent subgroup analysis of factors relating to steroid use. RESULTS:A total of 1223 patients met the study criteria for inclusion. Premature infants represented 19% of all children hospitalized with bronchiolitis. These infants had a longer length of stay (3.8 vs 2.6 days; P < .001) and a more severe hospital course. Rates of inhaled therapy and steroid utilization did not differ between premature and term infants. There was no difference in rates of documented positive response to albuterol, but premature infants were more likely to have a positive response to epinephrine. Steroid use in premature infants was associated with older age, history of wheeze, and albuterol use; documentation of albuterol effi cacy did not correlate with steroid use, however. CONCLUSIONS:Management decisions among term and premature infants with bronchiolitis were similar. Premature infants who received albuterol were more likely to receive steroids; however, the decision regarding steroid use was not associated with documentation of effi cacy of albuterol. The Clinical Management of Preterm Infants With BronchiolitisBronchiolitis is a leading cause of hospitalization of infants, resulting in more than $500 million in health care expenditures annually in the United States.1 It has been estimated that >20% of infants aged <1 year will have bronchiolitis-associated wheezing.2 In the United States, >12% of infants are born before 37 weeks' gestational age, and this rate is higher now than at any known historical level.3 Prematurity and chronic lung disease of prematurity are known risk factors for hospitalization in bronchiolitis, and chronic lung disease is disproportionately present among infants hospitalized with bronchiolitis. 4 Up to 14% of all premature infants will be hospitalized with bronchiolitis early in life, and they will typically have a more severe course and a longer length of stay (LOS) than full term infants.5-7 More than one-half of premature infants <29 weeks' gestational age may be admitted by guest on May 11, 2018 http://hosppeds.aappublications.org/ Downloaded from

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Health care utilisation of infants with chronic lung disease, related to hospitalisation for RSV infection

Cited by 177 publications

References 16 publications

The impact of respiratory viruses on lung health after preterm birth

The impact of respiratory viruses on lung health after preterm birth

Risk Factors for Hospital Readmission and Follow Up after NICU Discharge of Infants Born at Extremely Low Gestational Age in Metropolitan Melbourne

The Clinical Management of Preterm Infants With Bronchiolitis

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