Background: People with histories of homelessness and serious mental illness experience profound health disparities. Housing First is an evidenced-based practice that is working to end homelessness for these individuals through a combination of permanent housing and community-based supports.Methods Those who emerge from the shadows of homelessness bring the disparities in the U.S. health care system into sharper focus. We describe the development and evaluation of a community of solution 1 that addresses the dual problems of chronic homelessness and poor health outcomes experienced by people with serious mental illness (SMI) through a partnership between an academic medical center and a Housing First program. Housing First, an innovative and effective housing and treatment model, 2 works to end homelessness for people with SMI by offering immediate access to permanent supportive housing and intensive community-based interdisciplinary supports. However, once housed, people continue to face numerous, often untreated chronic health conditions, suggesting that a systematic approach to population health improvement is needed. Primary care and patient-centered medical homes (PCMHs) can play a significant role in helping to meet public health needs.3,4 This article offers an example of this process, in which an extended PCMH in the Thomas Jefferson University Department of Family and Community Medicine (DFCM) and a local nonprofit Housing First agency, Pathways to Housing-PA (PTH-PA), have partnered successfully to better meet the individual and population health needs of formerly homeless This article was externally peer reviewed.