Health Care-Associated Infections

Srinivasan, Lakshmi; Evans, Jacquelyn R.

doi:10.1016/b978-0-323-40139-5.00040-1

Cited by 5 publications

(1 citation statement)

References 231 publications

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“…Enterococci are one of the main causes of nosocomial infections, which are responsible for both endemic and epidemic healthcare-associated infections [109,110]. Enterococcus faecalis is a Gram-positive coccus and facultative anaerobe, commonly found as a human intestinal commensal.…”

Section: Antimicrobial Range Of Essential Oils-magnetite Nanosystemsmentioning

confidence: 99%

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-based strategies for developing nanoscaled carriers for their efficient delivery might offer potential solutions. Owing to their biocompatibility, biodegradability, low toxicity, ability to target a tissue specifically, and primary structures that allow for the attachment of various therapeutics, magnetite nanoparticles (MNPs) are an example of such nanocarriers that could be used for the efficient delivery of EOs for antimicrobial therapies. The aim of this paper is to provide an overview of the use of EOs as antibacterial agents when coupled with magnetite nanoparticles (NPs), emphasizing the synthesis, properties and functionalization of such NPs to enhance their efficiency. In this manner, systems comprising EOs and MNPs could offer potential solutions that could overcome the challenges associated with biofilm formation on prosthetic devices and antibiotic-resistant bacteria by ensuring a controlled and sustained release of the antibacterial agents.

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Section: Antimicrobial Range Of Essential Oils-magnetite Nanosystemsmentioning

confidence: 99%

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Mihai

Chircov

Grumezescu

et al. 2020

IJMS

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Contribution of staphylococcal virulence factors in the pathogenesis of thrombosis

Lichota,

Gwozdzinski,

Kowalczyk

et al. 2024

Microbiological Research

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Pediatric invasive device utility and harm: a multi-site point prevalence survey

Takashima,

Gibson,

Borello

et al. 2024

Pediatr Res

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Background and aims Invasive devices are widely used in healthcare settings; however, pediatric patients are especially vulnerable to invasive device-associated harm. This study aimed to explore invasive device utility, prevalence, harm, and clinical practice across three Australian pediatric tertiary hospitals. Methods In 2022–2023, a multi-center, observational, rolling-point-prevalence survey was conducted. Fifty-per-cent of inpatients were systemically sampled by random allocation. Patients with devices were then followed for up to 3-days for device-related complications/failures and management/removal characteristics. Results Of the 285 patients audited, 78.2% had an invasive device (n = 412 devices), with a median of 1 device-per-patient (interquartile range 1–2), with a maximum of 13 devices-per-patient. Over half of devices were vascular access devices (n = 223; 54.1%), followed by gastrointestinal devices (n = 112; 27.2%). The point-prevalence of all device complications on Day 0 was 10.7% (44/412 devices) and period-prevalence throughout the audit period was 27.7% (114/412 devices). The period-prevalence of device failure was 13.4% (55/412 devices). Conclusions The study highlighted a high prevalence of invasive devices among hospitalized patients. One-in-ten devices failed during the audit period. These findings underscore the need for vigilant monitoring and improved strategies to minimize complications and enhance the safety of invasive devices in pediatric hospital settings. Impact A high prevalence of invasive devices among hospitalized patients was reported. Of the 285 patients audited, almost 80% had an invasive device (total 412 devices), with a median of 1 device-per-patient and a maximum of 13 devices-per-patient. The most common devices used in pediatric healthcare are vascular access devices (n = 223; 54.1%), however, 16% (n = 36) of these devices failed, and one-third had complications. The point prevalence of all device complications at day 0 was 10.7% (44 out of 412 devices), with a period prevalence of 27.7% (114 out of 412 devices) throughout the audit period.

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Health Care-Associated Infections

Cited by 5 publications

References 231 publications

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Magnetite Nanoparticles and Essential Oils Systems for Advanced Antibacterial Therapies

Contribution of staphylococcal virulence factors in the pathogenesis of thrombosis

Pediatric invasive device utility and harm: a multi-site point prevalence survey

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