Health Benefits of Tea Consumption

Suzuki, Takuji; Miyoshi, Noriyuki; Hayakawa, Sumio; Imai, Shoichi; Isemura, Mamoru; Nakamura, Yoriyuki

doi:10.1007/978-3-319-23672-8_4

Cited by 26 publications

(28 citation statements)

References 85 publications

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“…Several epidemiological studies have shown the anti-cancer effects of consumption of tea. A survey in 2013 conducted by Yang and Hong of prospective cohort and case controlled studies which had been reported by 2008 revealed that green tea consumption showed risk-reduction in a total of 39 cases of breast, colon, esophagus, kidney/bladder, lung, ovary, pancreas, prostate, stomach cancers, whereas 46 cases showed no risk-reduction [ 1 , 13 ]. In the case of black tea, 28 and 92 cases showed risk-reduction and no risk-reduction, respectively, for these cancers [ 13 ].…”

Section: Anti-cancer Effects Of Green Teamentioning

confidence: 99%

“…These basic studies have also proposed mechanisms under which EGCG exerts these effects [ 1 , 2 , 3 , 4 , 5 ]. This review focuses mechanisms related to anti-oxidant and pro-oxidant effects, anti-inflammatory effects, anti-angiogenic effects, induction of apoptosis, modulation of epigenetic pathways and EGCG’s binding to cancer-related proteins which have been reviewed in many articles [ 26 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Anti-cancer Effects Of Green Teamentioning

confidence: 99%

“…Green tea is produced by processing of leaves of the plant Camellia sinensis (Theaceae) and is popularly consumed worldwide. Green tea has been shown to have beneficial effects on human health such as anti-cancer, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious and anti-neurodegenerative effects [ 1 , 2 ]. (−)-Epigallocatechin gallate (EGCG) is the most abundant catechin in green tea and believed to be mostly responsible for these biological effects ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

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Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

et al. 2020

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Tea and coffee are consumed worldwide and epidemiological and clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) and chlorogenic acid (CGA) are the major components of green tea polyphenols and coffee polyphenols, respectively, and believed to be responsible for most of these effects. Although a large number of cell-based and animal experiments have provided convincing evidence to support the anti-cancer effects of green tea, coffee, EGCG, and CGA, human studies are still controversial and some studies have suggested even an increased risk for certain types of cancers such as esophageal and gynecological cancers with green tea consumption and bladder and lung cancers with coffee consumption. The reason for these inconsistent results may have been arisen from various confounding factors. Cell-based and animal studies have proposed several mechanisms whereby EGCG and CGA exert their anti-cancer effects. These components appear to share the common mechanisms, among which one related to reactive oxygen species is perhaps the most attractive. Meanwhile, EGCG and CGA have also different target molecules which might explain the site-specific differences of anti-cancer effects found in human studies. Further studies will be necessary to clarify what is the mechanism to cause such differences between green tea and coffee.

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Section: Anti-cancer Effects Of Green Teamentioning

confidence: 99%

Section: Anti-cancer Effects Of Green Teamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

et al. 2020

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“…Different types of tea are produced from fresh tea leaf (Camellia sinensis): Green, black, white, and red tea which is different in terms of production methods. Each type of tea has its own characteristics including a different taste and different pharmacological activities [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Although green tea has been considered safe, emerging reports regarding the liver injury should not be ignored [5,11,12]. Although some in vivo studies have shown that green tea consumption could be hepatoinvasive [13,14], other studies have demonstrated that green tea consumption is quite safe [3,4,15].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Serki¹

2017

AJCEM

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Abstract:Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicininduced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of druginduced liver injury.

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Epigallocatechin‐3‐gallate activates the AMP‐activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes

Ding

Liu

et al. 2020

Journal Cellular Physiology

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Epigallocatechin-3-gallate (EGCG) plays a crucial role in hepatic lipid metabolism. However, the underlying regulatory mechanism of hepatic lipid metabolism by EGCG in canine is unclear. Primary canine hepatocytes were treated with EGCG (0.01, 0.1, or 1 μM) and BML-275 (an AMP-activated protein kinase [AMPK] inhibitor) to study the effects of EGCG on the gene and protein expressions associated with AMPK signaling pathway. Data showed that treatment with EGCG had greater activation of AMPK, as well as greater expression levels and transcriptional activity of peroxisome proliferator activated receptor-α (PPARα) along with upregulated messenger RNA (mRNA) abundance and protein abundance of PPARα-target genes. EGCG decreased the expression levels and transcriptional activity of sterol regulatory element-binding protein 1c (SREBP-1c) along with downregulated mRNA abundance and protein abundance of SREBP-1c target genes. Of particular interest, exogenous BML-275 could reduce or eliminate the effects of EGCG on lipid metabolism in canine hepatocytes. Furthermore, the content of triglyceride was significantly decreased in the EGCG-treated groups. These results suggest that EGCG might be a potential agent in preventing high-fat diet-induced lipid accumulation in small animals.

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Health Benefits of Tea Consumption

Cited by 26 publications

References 85 publications

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Epigallocatechin‐3‐gallate activates the AMP‐activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes

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