Objective
To examine the effect of maternal pre-pregnant body mass index (BMI) and recreational physical activity on perinatal mortality.
Design
A prospective cohort study.
Setting
The Norwegian Mother and Child Cohort (MoBa), 1999-2008.
Population
Singleton pregnancies without congenital anomalies (n=77 246).
Methods
Pre-pregnant BMI was classified as underweight (<18.5), normal weight (18.5-24.9), overweight (25-29.9), obese (30-34.9) and morbidly obese (BMI≥ 35). Risk estimates were obtained by logistic regression and adjusted for confounders.
Main outcome measures
Perinatal death (stillbirth ≥ 22 weeks plus early neonatal death 0-7 days after birth).
Results
An increased risk of perinatal death was seen in obese (odds ratio (OR) 2.4, 95% CI 1.7-3.4) and morbidly obese women (OR 3.3, 2.1-5.1), when compared to normal weight women. In the group participating in recreational physical activity during pregnancy, obese women had an OR of 3.2 (95% CI 2.2-4.7) for perinatal death relative to non-obese. In the non-active group the corresponding OR was 1.8 (95% CI 1.1-2.8) for obese women relative non-obese. The difference in perinatal mortality risk related to obesity between the active and non-active groups was statistically significant (p-value for interaction = 0.046, multiplicative model).
Conclusions
Maternal obesity was associated with a two- to three-fold increased risk of perinatal death when compared to normal weight women. For women with a BMI <30 the lowest perinatal mortality was seen in those performing recreational physical activity at least once a week.