Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Meng, Xiao; Zhou, Jing; Zhao, Cong; Gan, Ren‐You; Li, Hua Bin

doi:10.3390/foods9030340

Cited by 175 publications

(123 citation statements)

References 125 publications

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“…Regarding phenolic constituents, or polyphenols, also present in fruit, grains, and vegetables, data from several studies suggest that they have healthy properties [ 1 , 6 , 7 , 8 ]. Resveratrol, a non-flavonoid present in trace quantities, is a natural antioxidant and anti-inflammatory compound, known to play a key role in immunoregulation, metabolic syndrome, cardiovascular, neuroprotection, and cancer treatment [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. It has also received attention due to its antimicrobial activity against bacterial, fungal, and viral species in vitro [ 21 , 22 , 23 , 24 ].…”

Section: Introduction: An Overview Of Wine To the Past From The Prmentioning

confidence: 99%

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Martín

Grao‐Cruces

Millán-Linares

et al. 2020

Foods

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Wine production is an ancient human activity that generates several by-products, which include some constituents known for their potential in health care and for their role in the food or cosmetic industries. Any variety of grape (Vitis vinifera L.) contains nutrients and bioactive compounds available from their juice or solid parts. Grape seed extract has demonstrated many activities in disease prevention, such as antioxidant effects, which make it a potential source of nutraceuticals. Grape seed is a remarkable winery industry by-product due to the bioactivity of its constituents. Methods for recovery of oil from grape seeds have evolved to improve both the quantity and quality of the yield. Both the lipophilic and hydrophilic chemicals present in the oil of V. vinifera L. make this wine by-product a source of natural nutraceuticals. Food and non-food industries are becoming novel targets of oil obtained from grape seeds given its various properties. This review focuses on the advantages of grape seed oil intake in our diet regarding its chemical composition in industries not related to wine production and the economic and environmental impact of oil production.

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Section: Introduction: An Overview Of Wine To the Past From The Prmentioning

confidence: 99%

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Martín

Grao‐Cruces

Millán-Linares

et al. 2020

Foods

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“…Resveratrol has been shown to have a wide range of protective properties, including anti-oxidant, anti-inflammatory, anti-carcinogenic, cardio-protective, and immunomodulating properties [117,119,120]. The anti-inflammatory [34,121,122], anti-oxidant [123], anti-aging [124] and anti-OA properties [123,125], which are well-documented in the literature [126], are indeed remarkable. Furthermore, resveratrol has been reported to modulate the metabolism of lipids and to suppress the oxidation of low-density lipoproteins and the aggregation of platelets and other cells.…”

Section: Resveratrolmentioning

confidence: 86%

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

et al. 2020

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It is estimated that by 2023, approximately 20% of the population of Western Europe and North America will suffer from a degenerative joint disease commonly known as osteoarthritis (OA). During the development of OA, pro-inflammatory cytokines are one of the major causes that drive the production of inflammatory mediators and thus of matrix-degrading enzymes. OA is a challenging disease for doctors due to the limitation of the joint cartilage’s capacity to repair itself. Though new treatment approaches, in particular with mesenchymal stem cells (MSCs) that integrate the tissue engineering (TE) of cartilage tissue, are promising, they are not only expensive but more often do not lead to the regeneration of joint cartilage. Therefore, there is an increasing need for novel, safe, and more effective alternatives to promote cartilage joint regeneration and TE. Indeed, naturally occurring phytochemical compounds (herbal remedies) have a great anti-inflammatory, anti-oxidant, and anabolic potential, and they have received much attention for the development of new therapeutic strategies for the treatment of inflammatory diseases, including the prevention of age-related OA and cartilage TE. This paper summarizes recent research on herbal remedies and their chondroinductive and chondroprotective effects on cartilage and progenitor cells, and it also emphasizes the possibilities that exist in this research area, especially with regard to the nutritional support of cartilage regeneration and TE, which may not benefit from non-steroidal anti-inflammatory drugs (NSAIDs).

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“…Curcumin can also exert an anticancer and chemopreventative activity on breast cancer. In this context, curcumin exerts its antitumor effect not only through its specific mechanisms of action already described, but also thanks to a complex molecular signaling network that involves the mechanisms underlying the cell proliferative processes, the receptors of estrogen (ER) and human epidermal growth factor receptor 2 (HER2) (65,66).…”

Section: Nutraceuticals and Gene Expressionmentioning

confidence: 99%

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

Divella

Daniele

Savino

et al. 2020

Cancer Genomics Proteomics

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Epidemiological and clinical studies support the association between nutrition and development or progression of different malignancies such as colon, breast, and prostate cancer, defining these tumors as diet-associated cancer. The Mediterranean diet shows inverse associations with metabolic diseases, cardiovascular pathologies and various types of cancer. Many bioactive nutrients of the Mediterranean diet have been identified as factors protective against these types of pathologies. The epigenome has been identified as the primary goal of modulations in gene expression related to these molecular nutrients. In fact, they can modify the epigenome and can be incorporated into the 'epigenetic diet', which translates into a diet regimen that can be used therapeutically for health or preventative purposes. Most epigenetic changes are influenced by lifestyle and nutrition. Epigenetic therapy is a new area for the development of nutraceuticals whose absence of toxicity can represent a valid asset in cancer prevention strategies. Recent advances in understanding the mechanisms of nutrigenomics, nutrigenetics and nutraceuticals have led to the identification of superfoods capable of favorably conditioning gene expression. In this review, we highlight the importance of nutraceuticals present in the Mediterranean diet as epigenetic modifiers both in the mechanisms of tumor onset and as protective agents.

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Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Cited by 175 publications

References 125 publications

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

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