Health and sociodemographic factors associated with low muscle strength, muscle mass, and physical performance among people living with HIV

Oliveira, Vitor H F; Webel, Allison R.; Borsari, Ana L.; Cárdenas, José David G.; Deminice, Rafael

doi:10.1080/09540121.2022.2147482

Cited by 2 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IGF-1 and FGF2) during bone growth [7], whilst a range of bone-derived osteokines exert endocrine effects on muscle. Studies of HIV in adults report impaired muscle function [8,9]; however, few studies, particularly in Africa, have investigated muscle function in CWH. Those reported are often small, lack a control population [10,11], or focus on treatment-naive individuals [12].…”

Section: Introductionmentioning

confidence: 99%

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Gregson,

Rehman,

Rukuni

et al. 2023

Aids

View full text Add to dashboard Cite

Objectives: :To determine how muscle strength, power, mass, and density (i.e. quality) differ between children living with HIV (CWH) and those uninfected, and whether antiretroviral therapy (ART) regime is associated with muscle quality. Design: :A cross-sectional study in Harare, Zimbabwe. Methods: :The study recruited CWH aged 8–16years, taking ART for ≥2years, from HIV clinics, and HIV-uninfected children from local schools. Muscle outcomes comprised grip strength measured by hand-held Jamar dynamometer, lower-limb power measured by standing long-jump distance, lean mass measured by dual-energy X-ray absorptiometry, and muscle density (reflecting intramuscular fat) by peripheral quantitative computed tomography. Linear regression calculated adjusted mean differences (aMD) by HIV status. Results: :Overall, 303 CWH and 306 without HIV, had mean(SD) age 12.5(2.5) years, BMI 17.5(2.8), with 50% female. Height and fat mass were lower in CWH, mean differences(SE) 7.4(1.1)cm and 2.7(0.4)kgs, respectively. Male CWH had lower grip strength (aMD 2.5[1.1,3.9]kg, P < 0.001), long-jump distance (7.1[1.8,12.5]cm, P = 0.006), muscle density (0.58[0.12,1.05]mg/cm3, P = 0.018, but not lean mass 0.06[-1.08,1.21]kg, P = 0.891) versus boys without HIV; differences were consistent but smaller in females. Mediation analysis suggested the negative effect of HIV on jumping power in males was partially mediated by muscle density (P = 0.032). CWH taking tenofovir disoproxil fumarate (TDF) had lower muscle density (0.56[0.00,1.13]mg/cm3, P = 0.049) independent of fat mass, than CWH on other ART. Conclusions: :Perinatally-acquired HIV is associated, particularly in males, with reduced upper and lower-limb muscle function, not mass. Intra-muscular fat (poorer muscle quality) partially explained reductions in lower-limb function. TDF is a novel risk factor for impaired muscle quality.

show abstract

Section: Introductionmentioning

confidence: 99%

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Gregson,

Rehman,

Rukuni

et al. 2023

Aids

View full text Add to dashboard Cite

show abstract

The Risk of Malnutrition and Sarcopenia in Elderly People Living with HIV during the COVID-19 Pandemic

Thet,

Lappichetpaiboon,

Trakultritrung

et al. 2024

Nutrients

View full text Add to dashboard Cite

Malnutrition is a risk factor of sarcopenia in the elderly. During the COVID-19 pandemic, limited transportation and supply chain disruptions restricted access to nutritious foods. We assessed the nutritional status and sarcopenia risk in older people living with HIV (PLWH) on combination antiretroviral therapy in Thailand. This study was a hospital-based cohort among virally suppressed older PLWH who came for routine HIV clinic visits. The mini nutritional assessment (MNA), body composition analysis and 5-time chair stand test (CST) were performed to assess the nutritional status, muscle mass and physical performance, respectively. A total of 177 PLWH were enrolled (57.60% male). The median age was 58 years (IQR 55–62 years). Thirty-five participants (19.8%) were at risk of developing sarcopenia, and 28.2% had abnormal nutritional status. Muscle mass correlated positively with nutritional scores (r = 0.355, p < 0.001) but negatively with 5-time CST duration (r = −0.173, p = 0.021). In the multivariate model, muscle mass was associated with age, sex, mid-arm circumference, calf circumference and 5-time CST duration. In a well-viral-suppressed older Asian PLWH cohort, given the positive correlation between nutritional status and muscle mass, the nutritional status of older PLWH should be routinely evaluated and monitored.

show abstract

Health and sociodemographic factors associated with low muscle strength, muscle mass, and physical performance among people living with HIV

Cited by 2 publications

References 52 publications

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

Perinatal HIV infection is associated with deficits in muscle function in children and adolescents in Zimbabwe

The Risk of Malnutrition and Sarcopenia in Elderly People Living with HIV during the COVID-19 Pandemic

Contact Info

Product

Resources

About