Health and Medical Applications of Tubular Clay Minerals

Aguzzi, Carola; Sandri, Giuseppina; Cerezo, Pilar; Carazo, E.; Viseras, César

doi:10.1016/b978-0-08-100293-3.00026-1

Cited by 21 publications

(15 citation statements)

References 91 publications

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“…The combination of clay minerals with other ingredients, such as polymers, allows the formation of scaffolding materials. In these occasions, clay minerals not only improved the mechanical strength and functionality of the polymers, but they also acted as synergistic ingredients for wound healing [ 41 , 42 , 43 , 44 ]. Biocompatibility of clay minerals such as halloysite, montmorillonite, palygorskite, sepiolite and imogolite have been widely studied [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

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Background: hydrogels prepared with natural inorganic excipients and spring waters are commonly used in medical hydrology. Design of these clay-based formulations continues to be a field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay, and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to study the morphology of fibroblasts during the wound healing process. Results: all the ingredients demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays as hydrogels improved biocompatibility with respect to powder samples at the same concentration. Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore, accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing formulations. Moreover, these results open new prospects for these ingredients to be used in new therapeutic or cosmetic formulations.

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Section: Introductionmentioning

confidence: 99%

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

et al. 2020

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“…Also, several chapters in the book Nanosized Tubular Clay Minerals -Halloysite and Imogolite 21 give an excellent overview on HNTs mineralogy, 22,23 methods for characterization, 24,25 safety considerations, 26 modification strategies, 27,28 and applications. [29][30][31][32][33] Additional more recent reviews which highlight the physical and chemical modification of HNTs for a range of future applications are. 15,34,35 Other noteworthy reviews by leading research groups in the field focus on the prominent biomedical avenues [16][17][18][19]35,36 in general, and drug delivery in particular.…”

Section: Noteworthy Background Literaturementioning

confidence: 99%

“…Some of the most noteworthy biomedical applications of HNTs are based on their interaction with cells through which cells can subsequently uptake the clay nanotubes or adhere to them. 30 Generally, the interaction between cells and any type of nanoparticles is affected by various forces such as van der Waals and electrostatic forces. 139 Thus, particle, size, shape and surface charge play a crucial role; particles that are smaller, more elongated or more positively-charged can penetrate more easily through the negatively-charged cell membrane.…”

Section: Principles Of Cell-hnts Interactionsmentioning

confidence: 99%

Halloysite nanotubes – the nano-bio interface

Setter

Segal

2020

Nanoscale

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“…Halloysite is a two‐layered aluminosilicate chemically similar to kaolin, with prevailing hollow tubular structure in the nanometer range . Essential features, as hollow tubular morphology and outer and inner surface charges, have made halloysite nanotubes (HLNTs) well documented carriers for encapsulation and release of drug molecules . In a previous work, it was shown that INH is spontaneously adsorbed by HLNTs, giving a self‐assembled and thermodynamic stable (Δ H = 70.40 kJ/mol; Δ S = 0.25 9 kJ/molK) nanohybrid (INH‐loaded HNLTs), in which drug molecules were adsorbed both onto the inner and at the outer surface of the nanotubes …”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26] Essential features, as hollow tubular morphology and outer and inner surface charges, have made halloysite nanotubes (HLNTs) well documented carriers for encapsulation and release of drug molecules. [27][28][29][30][31][32][33][34][35] In a previous work, it was shown that INH is spontaneously adsorbed by HLNTs, giving a self-assembled and thermodynamic stable (ΔH = 70.40 kJ/mol; ΔS = 0.25 9 kJ/molK) nanohybrid (INH-loaded HNLTs), in which drug molecules were adsorbed both onto the inner and at the outer surface of the nanotubes. 21 Given these premises, aim of this work was to assess biological compatibility as well as biopharmaceutical and technological performances of INH-loaded HNLTs to effectively improve the oral bioavailability of the drug and enhance INH compatibility in presence of the other tuberculostatic drugs.…”

Section: Introductionmentioning

confidence: 99%

Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment

Carazo

Sandri

Cerezo

et al. 2019

J Biomedical Materials Res

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Halloysite nanotubes (HLNTs) were used as nanocarriers of the tuberculostatic agent isoniazid (INH), a BCS (Biopharmaceutics Classification System) class III drug. Self‐assembling nanohybrids (INH‐loaded HLNTs) with an average outer diameter of 90 nm and polydispersity index of 0.7 approximately, were obtained by spontaneous adsorption of INH molecules to HLNTs powder in aqueous medium. The nanohybrids were aimed to improve oral drug bioavailability and reduce physicochemical incompatibility of INH with other concomitantly administered tuberculostatic agents. In vitro drug release from INH‐loaded HLNTs was successfully fitted to a diffusive kinetic law founded on the adsorption–desorption equilibrium between drug molecules in solution and solid inorganic excipients. INH‐loaded HLNTs showed good in vitro biocompatibility toward Caco‐2 cells at the concentrations studied (up to 1233 μg/mL), with improved cell proliferation. Permeability tests showed that INH transport across Caco‐2 cellular membranes was greatly enhanced and fluorescent microscopy confirmed that the drug encapsulated into nanohybrid was effectively internalized by the cells. INH‐loaded HLNTs enhanced stability of the drug in presence of other tuberculostatic agents, both in binary and quaternary combinations. It has been demonstrated that simple interaction between INH with HLNTs leads to drug permeability and stability improvements that could greatly facilitate the design of multiple drug dosage forms, an actual challenge in oral treatment of tuberculosis. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2019.

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Health and Medical Applications of Tubular Clay Minerals

Cited by 21 publications

References 91 publications

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Wound Healing Activity of Nanoclay/Spring Water Hydrogels

Halloysite nanotubes – the nano-bio interface

Halloysite nanotubes as tools to improve the actual challenge of fixed doses combinations in tuberculosis treatment

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