Healing parameters in a rabbit partial tendon defect following tenocyte/biomaterial implantation

Stoll, Christiane; John, Thilo; Conrad, C.; Lohan, Anke; Hondke, Sylvia; Ertel, Wolfgang; Kaps, Christian; Endres, Michaela; Sittinger, Michael; Ringe, Jochen; Schulze‐Tanzil, Gundula

doi:10.1016/j.biomaterials.2011.03.026

Cited by 95 publications

(101 citation statements)

References 29 publications

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“…Compared to the control groups (scaffold alone and without scaffold) macroscopic and microscopic appearance was superior. Unfortunately no biomechanical testing was performed in this study (Stoll et al 2011). In massive rotator cuff tear a functioning scaffold model is desirable.…”

Section: Scaffoldsmentioning

confidence: 96%

Tendon Healing with Growth Factors

Müller¹,

Todorov²,

Heisterbach³

et al. 2012

Achilles Tendon

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Section: Scaffoldsmentioning

confidence: 96%

Tendon Healing with Growth Factors

Müller¹,

Todorov²,

Heisterbach³

et al. 2012

Achilles Tendon

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“…Three HE and Masson trichrome stained samples in each group were evaluated by a histological scoring system (Table 2). Both scoring systems were modified from a previous study, 27 and scoring was performed in a blinded fashion.…”

Section: Rat Patellar Tendon Repair Modelmentioning

confidence: 99%

Human iPSC-Derived Neural Crest Stem Cells Promote Tendon Repair in a Rat Patellar Tendon Window Defect Model

Wang

Liu

et al. 2013

Tissue Engineering Part A

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Induced pluripotent stem cells (iPSCs) hold great potential for cell therapy and tissue engineering. Neural crest stem cells (NCSCs) are multipotent that are capable of differentiating into mesenchymal lineages. In this study, we investigated whether iPSC-derived NCSCs (iPSC-NCSCs) have potential for tendon repair. Human iPSCNCSCs were suspended in fibrin gel and transplanted into a rat patellar tendon window defect. At 4 weeks posttransplantation, macroscopical observation showed that the repair of iPSC-NCSC-treated tendons was superior to that of non-iPSC-NCSC-treated tendons. Histological and mechanical examinations revealed that iPSCNCSCs treatment significantly enhanced tendon healing as indicated by the improvement in matrix synthesis and mechanical properties. Furthermore, transplanted iPSC-NCSCs produced fetal tendon-related matrix proteins, stem cell recruitment factors, and tenogenic differentiation factors, and accelerated the host endogenous repair process. This study demonstrates a potential strategy of employing iPSC-derived NCSCs for tendon tissue engineering.

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“…In addition, histology of specimens belonging to the treatment legs showed a similar and structurally well-organized tissue composition when compared with the control specimens at the end of the 4th week. In a previous study conducted with partial tendon defect in rabbits, it was reported that 6 weeks after tendon surgery, most of the specimens had a looser extracellular matrix (ECM) combined with hypercellularity and hypervascularity (34). In contrast, these findings were mostly observed in the 2-week group.…”

Section: Discussionmentioning

confidence: 97%