Healing of tooth extraction wounds in rats with renal hypertension. A histological study.

Carvalho, Antônio Augusto Ferreira; Castro, A. Lima De; Melhado, Ronaldo Maia; Castro, João César Bedran de

doi:10.2334/josnusd1959.25.214

Cited by 5 publications

(5 citation statements)

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“…The lower med BMD at 28 days in SHRs revealed a reduced quantity of bone tissue or a less mineralized bone tissue. Alveolar healing process alteration, characterized by immature bone tissue, was also noted between 9 and 21 days after upper incisor tooth extraction using a renal hypertensive (Goldblatt rats 1-kidney, 1-clip) animal model 7 . Bastos, et al 3 (2010) observed in the tibia of SHR that the mean percentage of trabecular bone area formed after critical-size defect was significantly lower when compared to normotensive rats.…”

Section: Discussionmentioning

confidence: 97%

Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

et al. 2012

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Hypertension is one of the most important public health problems worldwide. If undiagnosed or untreated, this pathology represents a systemic risk factor and offers unfavorable conditions for dental treatments, especially those requiring bone healing.Objectives The purpose of this study was to demonstrate, by analysis of bone mineral density (BMD), that the alveolar bone healing process is altered in spontaneously hypertensive rats (SHRs). Material and Methods Wistar rats and SHRs were submitted to extraction of the upper right incisor and were euthanized 7, 14, 21, 28 and 42 days after surgery. Right maxillae were collected, radiographed and analyzed using Digora software. BMD was expressed as minimum (min), middle (med) and maximum (max) in the medium (MT) and apical (AT) thirds of the dental alveolus. ResultsThe results were compared across days and groups. Wistar showed difference in med and max BMD in the MT between 7 and 28 and also between 14 and 28 days. The AT exhibited significant difference in med and min BMD between 7 and 28 days, as well as difference in min BMD between 28 and 42 days. SHRs showed lower med BMD in the MT at 28 days when compared to 21 and 42 days. Differences were observed across groups in med and min BMD at day 28 in the MT and AT; and in max BMD at 14, 21 and 42 days in the MT. Conclusions These results suggest that the alveolar bone healing process is delayed in SHRs comparing with Wistar rats.

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Section: Discussionmentioning

confidence: 97%

Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

et al. 2012

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“…18,25 Although changes in cellular activity have been described in the bone metabolism of SHRs, these changes did not seem to adversely affect bone repair when the hypertensive strain was compared to the WKY strain.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 In monocortical defects on rat femur, SHR presented faster granulation tissue growth and bone healing than did normotensive rats, although bone matrix production was reduced at later periods because osteoblasts showed low cellular activity. 20 Recently, it has been found that untreated male SHR show alveolar bone with a high expression of RANKL (receptor activator of nuclear factor kappa-B ligand, a protein involved in osteoclast activation), a high ratio of RANKL/OPG (osteoprotegerin, a decoy receptor for RANKL), a high number of positive tartrate resistant acid phosphatase cells (an enzyme highly expressed by osteoclasts), greater bone loss, and reduced bone density.…”

Section: Discussionmentioning

confidence: 99%

Bone healing of mandibular critical-size defects in spontaneously hypertensive rats

2013

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Few articles have shown changes in bone metabolism caused by hypertension. The objective of this study was to investigate the relationship between hypertension and bone healing. Circular critical-size defects 5 mm and 2 mm in diameter were created, respectively, on the left and right side of the mandible in 40 spontaneously hypertensive and 40 control Wistar-Kyoto rats. Five animals from each strain were killed 2, 3, 5, 10, 15, 30, 60 and 90 days after surgery. The macroscopic evaluation showed great mandibular angle deformation on the left side and non-healed defects on both sides and groups. Histological evaluation revealed similar bone healing on both sides, with initial necrosis in the central area, and fibrosis and angiogenesis within the first 5 days. From the 10 th postoperative day on, the newly formed bone displayed progressive thickening until the 90 th postoperative day, when the defect margins presented a compact bone structure. Furthermore, the statistical analysis of the histometric data did not reveal any significant hypertension effect on bone healing in the defect area. These results suggest that bone healing was not different between spontaneously hypertensive rats and control rats.

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“…Se considerar que os animais WKY sejam pré-hipertensos, então os resultados encontrados no presente estudo com ambas as linhagens são similares aos de Murata et al (1967) e Carvalho et al (1983), no que diz respeito ao atraso na reparação óssea. A redução do aporte sangüíneo para os rins feita por esses autores aumenta a liberação de renina e, conseqüentemente, de Ang II, no mesmo processo que na hipertensão primária.…”

Section: Discussionunclassified

“…Apenas quatro trabalhos são encontrados na literatura: Murata et al (1967), Carvalho et al (1983), Pereira et al (2007) e Nobre et al (2008), cada qual avaliando uma forma diferente da hipertensão ou local de reparação óssea. Murata et al (1967) e Carvalho et al (1983) provocaram hipertensão renal, respectivamente em cães e ratos. Os cães tiveram seus pré-molares inferiores extraídos, e os ratos, o incisivo central direito.…”

Section: Hipertensão Na Reparação óSseaunclassified

Avaliação histológica da reparação óssea em defeitos bicorticais no ângulo de mandíbula de ratos geneticamente hipertensos e de seus controles Wistar-Kyoto

Chin¹

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Arterial hypertension may affect the quality of bone repair because this disease is characterized by physiopathological vascular and bone metabolism changes. With the objective of evaluating the bone neoformation and remodeling, this study investigated the process of bone repair in spontaneously hypertensive rats (SHR) and their match controls Wistar-Kyoto (WKY). Through-in-through defects were done with trephine burs in the mandibular angle area, of 2mm diameter on the right side and 5mm diameter on the left side. The animals were divided into groups of five individuals each one and killed after 2, 3, 5, 10, 15, 30, 60 and 90 postoperative days; the mandibles were removed, fixed in 10% formalin solution, decalcified with 20% formic acid, and embedded in paraffin; the histological sections of 7 µm thickness were stained with hematoxylin and eosin. The images were captured with 40x magnification and the defect area was measured by the image processing program Image J version 1.4. The statistical analysis showed that there is no significant difference in the comparison of WKY and SHR strains (p = 0,884), independent of periods or sides; among periods, in the WKY strain (p = 0,101) and SHR one (p = 0,479), independent of sides; among periods by strains on the right side; and among strains by sides, left side with p = 0,466 and right side with p = 0,689, independent of periods. There is a significant difference between left and right side (p < 0,001), independent of strains and periods; between sides by strains, WKY and SHR, both with p < 0,001; among periods by strains on the left side, which WKY 15 days group showed an area smaller than WKY 60 days and SHR 10 days groups, and WKY 60 days group showed an area bigger than SHR 30 days and SHR 60 days groups. Despite the changes founded on the left side that could be attributed to the functional remodeling of the mandibular bone, there were no differences in the bone repair of 5mm and 2mm diameter defects between spontaneously hypertensive rats and their match controls Wistar-Kyoto.

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Healing of tooth extraction wounds in rats with renal hypertension. A histological study.

Cited by 5 publications

References 11 publications

Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

Alveolar bone healing process in spontaneously hypertensive rats (SHR): A radiographic densitometry study

Bone healing of mandibular critical-size defects in spontaneously hypertensive rats

Avaliação histológica da reparação óssea em defeitos bicorticais no ângulo de mandíbula de ratos geneticamente hipertensos e de seus controles Wistar-Kyoto

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