Healing of the bones in juvenile Paget's disease treated by human calcitonin

Doyle, F. H.; Woodhouse, Nicholas; Glen, A.I.M.; Joplin, G. F.; MacIntyre, I.

doi:10.1259/0007-1285-47-553-9

Cited by 57 publications

(19 citation statements)

References 6 publications

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“…Furthermore, calcitonin is reported to not only arrest the disease progress, but it can also reverse the long bone abnormalities in terms of external dimensions and shape (8). Treatment with diphosphonate (pamidronate) may be equally effective (9-11). While JPD generally requires medical treatment, such a strategy was not applied in the present case due to a lack of general symptoms.…”

Section: Discussionmentioning

confidence: 99%

Juvenile Paget's Disease with Paranasal Sinus Aplasia

Bae

Kwon

Kim

et al. 2008

Clin Exp Otorhinolaryngol

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Juvenile Paget's disease (JPD) is a rare skeletal disorder that's characterized by bone demineralization and elevated levels of serum alkaline phosphatase. JPD involves the paranasal sinuses in extremely rare cases. We report here on a 25-month-old Asian male who was diagnosed of JPD associated with aplasia of the paranasal sinuses, but not the ethmoid sinuses. The patient was successfully treated by surgery and we undertook no medical intervention. This appears to be the first reported case of JPD associated with bilateral paranasal sinus aplasia.

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Section: Discussionmentioning

confidence: 99%

Juvenile Paget's Disease with Paranasal Sinus Aplasia

Bae

Kwon

Kim

et al. 2008

Clin Exp Otorhinolaryngol

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“…The second example was in our patient with juvenile paget's disease who fractured his right clavicle after collision with a metal post when swinging a baseball bat. Within 2 months his right humerus showed dramatic intracortical resorption of bone, the appearances resembling those of his untreated disease 6 years previously (12). After a further 3 months, the bone had reverted to its appearance one year before the occurrence of the fracture (Figure 9).…”

Section: Patientsmentioning

confidence: 84%

Radiologic observations on bone resorption in Paget's Disease

Doyle

Banks

Pennock

1980

Arthritis & Rheumatism

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The diagnosis of Paget's disease of bone at its earliest osteolytic phase is difficult and requires radiographs of the highest quality. Calcitonin controls the bone resorption of uncomplicated Paget's disease but does not prevent disuse osteoporosis in normal and pagetic bones. Cessation of treatment leads to a recurrence of the osteolytic phase of the disease in some patients. Retreatment with human calcitonin arrests the bone resorption and permits bony consolidation of resorption clefts.

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“…Calcitonin and bisphosphonates, which act directly on osteoclasts, have been used to treat juvenile Paget's disease, 11,12 but until recently there have been no data on their long-term effectiveness. Two recent studies have suggested that intensive intravenous bisphosphonate treatment can suppress bone turnover and prevent deformity in affected children.…”

Section: Discontinuation Of Treatmentmentioning

confidence: 99%

Recombinant Osteoprotegerin for Juvenile Paget's Disease

Cundy

Davidson²,

Rutland

et al. 2005

N Engl J Med

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Juvenile Paget's disease, a genetic bone disease characterized by accelerated bone turnover, results from inactivating mutations in the gene encoding osteoprotegerin--a key regulator of osteoclastogenesis. The effects of recombinant osteoprotegerin were investigated in two adult siblings with juvenile Paget's disease. Bone resorption (assessed by N-telopeptide excretion) was suppressed by once-weekly subcutaneous doses of 0.3 to 0.4 mg per kilogram of body weight. After 15 months of treatment, radial bone mass increased in one patient by 9 percent and in the other by 30 percent, skeletal bisphosphonate retention decreased by 37 percent and 55 percent, respectively, and there was radiographic improvement. Apart from mild hypocalcemia and hypophosphatemia, no apparent adverse events occurred.

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Healing of the bones in juvenile Paget's disease treated by human calcitonin

Cited by 57 publications

References 6 publications

Juvenile Paget's Disease with Paranasal Sinus Aplasia

Juvenile Paget's Disease with Paranasal Sinus Aplasia

Radiologic observations on bone resorption in Paget's Disease

Recombinant Osteoprotegerin for Juvenile Paget's Disease

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