Healing of subcutaneous tendons: Influence of the mechanical environment at the suture line on the healing process

Massoud, Elsayed Ibraheem Elsayed

doi:10.5312/wjo.v4.i4.229

Cited by 13 publications

(8 citation statements)

References 127 publications

(192 reference statements)

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“…These exercises have been shown to promote cross-linking of collagen fibers and facilitate tendon remodeling [4] and cause an upregulation of insulin-like growth factor (IGF) that promotes cellular proliferation and matrix remodeling [46]. Mechanical proprieties of physical exercises are able to affect tendon’s fibers reorganization and healing [53]. Some protocols include eccentric exercise alone, such as Alfredson protocol for Achilleous tendinopathy [54].…”

Section: Common Therapeutic Optionsmentioning

confidence: 99%

Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review

et al. 2019

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Tendinopathies are very common in general population and a huge number of tendon-related procedures take place annually worldwide, with significant socio-economic repercussions. Numerous treatment options are commonly used for tendon disorders. Besides pharmacological and physical therapy, nutrition could represent an additional tool for preventing and treating this complex pathology that deserve a multidisciplinary approach. In recent years, nutraceutical products are growing up in popularity since these seem to favor the prevention and the healing processes of tendon injuries. This narrative literature review aims to summarize current understanding and the areas of ongoing research about the management of tendinopathies with the help of oral supplementation.

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Section: Common Therapeutic Optionsmentioning

confidence: 99%

Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review

et al. 2019

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“…These exercises have been shown to promote cross-linking of collagen fibers and facilitate tendon remodeling and cause an upregulation of insulin-like growth factor (IGF) that promotes cellular proliferation and matrix remodeling. Mechanical proprieties of physical exercises are able to affect tendon's fibers reorganization and healing [28].…”

Section: Therapeutic Exercisementioning

confidence: 99%

Platelet-Rich Plasma in Management of Tendinopathy

Ahmed

Mohammady

Lotfy

2020

Benha Journal of Applied Sciences

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Tendons are vital component of our musculoskeletal system that link between the dynamic and the static part transmitting the forces generated by muscles to bony attachments producing joint motion and stabilize joints. Chronic painful tendon disorders are common in athletic and sedentary individuals. Tendon degeneration may occur when tissue breakdown exceeds the rate of tissue healing due to extrinsic factors such as tendon overload, excessive mechanical stimulation, training errors, fatigue or chemical stresses. Choices of treatment often change in parallel with physiopathological discoveries regarding tendinopathy. Platelets Riched plasma (PRP) is defined as a volume of the plasma fraction of autologous blood having a platelet concentration of 5 times more than base line. Injection of platelet-rich plasma (PRP) is considered a promising new treatment in management of tendinopathy. Platelet-rich plasma (PRP) injections are widely accepted by patients because the injection is produced from the patient's own blood and the risk of adverse effects is minimal. The aim of this Syistimic Review is to highlight on the recent trends in management of tendinopathy, especially platelet rich plasma.

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“…Accordingly, a high number of fibroblasts are expected in a region which experiences great tensile forces due to the phenomenon of durotaxis or mechanotaxis (Lo, 2000;Tschumperlin, 2013). This may be important for tendon repair healing (Massoud AND Ibraheem, 2013).…”

Section: Cellularity Of the Patellar Tendonmentioning

confidence: 99%

Regional differences in the cellularity and vascularity of the patellar tendon

Wambua¹,

Awori²,

Kigera³

et al. 2018

Anat. J. Afr.

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The patellar tendon (PT) attaches to the apex of the patella and tibial tuberosity. Its response to tensile forces is influenced by the distribution of fibroblasts and its vascularity. The vascularity and distribution of fibroblasts influence the tendons ability to repair microtears. Microtears of the PT result in patellar tendinopathy. There is however, paucity of data on the regional distribution of vascular and cellular elements in the PT which might explain why microtears occur in the posterior-proximal third. One hundred and two pairs of patellar tendons were obtained from postmortem specimens. Sections from the proximal, middle and distal third from the anterior and posterior lamina of 20 pairs of the patellar tendon (10 male, 10 female) were processed for microscopy to demonstrate the cellularity and vascularity of the tendon. The vascularity was highest in the middle third of the anterior lamina. The posterior lamina of the tendon was less vascular than the anterior lamina. The posterior lamina was more cellular than the anterior with the proximal third showing the highest number of nuclei. These findings indicate that the pre-patellar genicular anastomosis contributes significantly to the vascularity of the anterior lamina while the anastomosis located in Hoffa’s fat pad may be less rich and thus resulting in lower vascularity for the posterior lamina. Lower vascularity implies less healing ability after microtears. Therefore, orthopedic surgeons should be aware of this precarious pattern of vascularity to the posterior lamina. The posterior lamina’s high cellularity especially in the proximal third indicates that it may experience greater stress and via durotaxis more fibroblasts migrate to that region to produce more collagen fibers for resilience. The greater tensile stress experienced by the posterior-proximal third and its lower vascularity may explain why it is most susceptible to microtears.Key words: Patella tendon, regional differences, cellularity, vascularity, patella tendinopathy

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Healing of subcutaneous tendons: Influence of the mechanical environment at the suture line on the healing process

Cited by 13 publications

References 127 publications

Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review

Tendinopathy: Pathophysiology, Therapeutic Options, and Role of Nutraceutics. A Narrative Literature Review

Platelet-Rich Plasma in Management of Tendinopathy

Regional differences in the cellularity and vascularity of the patellar tendon

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