Healing of experimentally created defects: a review

Aaboe, Merete; Pinholt, Else Marie; Hjörting-Hansen, E.

doi:10.1016/0266-4356(95)90045-4

Cited by 95 publications

(66 citation statements)

References 99 publications

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“…1 However, potential complications emerging at the donor site, such as resorption without subsequent maintenance of bony contour and chronic pain, may accompany the procedure. 2,3 Therefore, research for alternative graft materials is ongoing. These graft materials should increase the bone volume in the grafted area to give initial stability at the implant site.…”

Section: Introductionmentioning

confidence: 99%

Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations

Groeneveld

Bergh

Holzmann

et al. 1999

J. Biomed. Mater. Res.

106

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For reconstruction of the severely resorbed lateral maxilla for dental implant placement, one of the successful procedures is to elevate the maxillary sinus floor by implanting demineralized bone matrix (DBM). We studied bone formation in DBM grafts in the lateral maxilla in humans by means of histology and histomorphometry. Six months after grafting, at the time of dental implantation biopsies were taken from the grafted areas of seven patients. All biopsies contained mineralized matrix (MM) in the grafted area. At close inspection, three types of mineralization were found. First, lamellar biomineralization was seen in and near the maxillary host bone. Second, remineralization was observed in some particles that probably had not been completely demineralized. In the area connecting the graft and host bone, where woven bone was formed against DBM particles, a third mechanism was detected. In this case many dotlike foci of remineralization appeared close to the bone-DBM interface. The remineralized DBM and woven bone were both subsequently remodeled. Bone formation was most active in the area adjoining the maxillary host bone. We conclude that in human sinus floor elevation, allogenic DBM increases mineralized tissue volume by osteoconduction that is supported by the remineralization processes. Osteoinduction by this material seems questionable.

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Section: Introductionmentioning

confidence: 99%

Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations

Groeneveld

Bergh

Holzmann

et al. 1999

J. Biomed. Mater. Res.

106

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“…For this purpose, several approaches have been attempted for defect filling and subsequent regeneration, including autogenous and xenogenous bone grafting and synthetic biomaterials [7]. Due to its ideal biocompatibility and osteogenic properties, autogenous bone taken from a secondary surgical site has been widely utilized and still considered as the ''golden standard'', such as the autogenous bone tissue derived from iliac crest grafted onto the intertransverse process for the fusion of the lumbar spine [8,9]. However, the use of autogenous bone has limitations, including availability and unpredictable healing kinetics.…”

Section: Introductionmentioning

confidence: 99%

Human mesenchymal stem cells and biomaterials interaction: a promising synergy to improve spine fusion

et al. 2012

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Purpose Spine fusion is the gold standard treatment in degenerative and traumatic spine diseases. The bone regenerative medicine needs (i) in vitro functionally active osteoblasts, and/or (ii) the in vivo induction of the tissue. The bone tissue engineering seems to be a very promising approach for the effectiveness of orthopedic surgical procedures, clinical applications are often hampered by the limited availability of bone allograft or substitutes. New biomaterials have been recently developed for the orthopedic applications. The main characteristics of these scaffolds are the ability to induce the bone tissue formation by generating an appropriate environment for (i) the cell growth and (ii) recruiting precursor bone cells for the proliferation and differentiation. A new prototype of biomaterials known as ''bioceramics'' may own these features. Bioceramics are bone substitutes mainly composed of calcium and phosphate complex salt derivatives. Methods In this study, the characteristics bioceramics bone substitutes have been tested with human mesenchymal stem cells obtained from the bone marrow of adult orthopedic patients. Results These cellular models can be employed to characterize in vitro the behavior of different biomaterials, which are used as bone void fillers or three-dimensional scaffolds.Conclusions Human mesenchymal stem cells in combination with biomaterials seem to be good alternative to the autologous or allogenic bone fusion in spine surgery. The cellular model used in our study is a useful tool for investigating cytocompatibility and biological features of HA-derived scaffolds.

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“…In reconstructive craniomaxillofacial surgery, autogenous bone continues to be the most widely used graft material due to its favorable biological properties in terms of the formation of new bone tissue 1,9,20 . However, its utilization involves a number of inconveniences, such as the difficulty to predict the final outcome, insufficient amounts of autogenous bone, the need for extensive and long-lasting surgery to obtain the graft and the risk of infection at the donor site 2,11,13,17,21,25 .…”

Section: Introductionmentioning

confidence: 99%

Radiographic and histological study of perennial bone defect repair in rat calvaria after treatment with blocks of porous bovine organic graft material

et al. 2004

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ver the last few years, various bone graft materials of bovine origin to be used in oromaxillofacial surgeries have entered the market. In the present study, we determined the capacity of a block organic bone graft material (Gen-ox, Baumer SA, Brazil) prepared from bovine cancellous bone to promote the repair of critical size bone injuries in rat calvaria. A transosseous defect measuring approximately 8mm in diameter was performed with a surgical trephine in the parietal bone of 25 rats. In 15 animals, the defects were filled with a block of graft material measuring 8mm in diameter and soaked in the animal's own blood, and in the other 10 animals the defects were only filled with blood clots. The calvariae of rats receiving the material were collected 1, 3 and 6 months after surgery, and those of animals receiving the blood clots were collected immediately and 6 months after surgery. During surgery, the graft material was found to be of easy handling and to adapt perfectly to the receptor bed after soaking in blood. The results showed that, in most animals treated, the material was slowly resorbed and served as a space filling and maintenance material, favoring angiogenesis, cell migration and adhesion, and bone neoformation from the borders of the lesion. However, a foreign body-type granulomatous reaction, with the presence of numerous giant cells preventing local bone neoformation, was observed in two animals of the 1-month subgroup and in one animal of the 3-month subgroup. These cases were interpreted as resulting from the absence of demineralization and the lack of removal of potential antigen factors during production of the biomaterial. We conclude that, with improvement in the quality control of the material production, block organic bone matrix will become a good alternative for bone defect repair in the oromaxillofacial region due to its high osteoconductive capacity.

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Healing of experimentally created defects: a review

Cited by 95 publications

References 99 publications

Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations

Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations

Human mesenchymal stem cells and biomaterials interaction: a promising synergy to improve spine fusion

Radiographic and histological study of perennial bone defect repair in rat calvaria after treatment with blocks of porous bovine organic graft material

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