Healing of donor sites of connective tissue grafts harvested by the single incision technique: A randomized clinical trial evaluating the use of collagen hemostatic sponge with or without sutures

Abstract

Background:The aim of this study was to evaluate the effect of suturing on the early wound healing of donor sites of subepithelial connective tissue grafts (SCTG), harvested by the single incision technique (SIT), following the application of a collagen sponge.Methods: Thirty-six patients were randomized to receive a collagen sponge with or without sutures in the palatal donor sites following connective tissue grafting via the SIT. Outcome variables were early healing index (EHI) at 7, 14, and 30 days, self-reported pain using a visual analogue scale (VAS) recorded on the 0 to 100 scale at 7 and 14 days, and immediate and delayed bleeding. Results: No significant differences were found between groups at baseline. EHI index showed no differences between groups in all-time intervals. Eight subjects from suture group (SG) and 10 from no suture group (nSG) showed complete wound closure at day 14 (P >0.05) and at 30 days, complete closure was observed in 35 out of 36 patients. Four subjects from the SG and three from the nSG had immediate bleeding (P >0.05), while delayed bleeding was observed in two subjects from the SG and three from the nSG during the first week of healing (P >0.05). No differences were found in VAS scale between groups (SG, 36.2 ± 24.8; nSG, 21.5 ± 24.2, P >0.05). Conclusion:It can be concluded that when a collagen sponge is placed in palatal donor areas of SCTG harvest by means of the SIT (incision length of ≈15 mm), sutured and non-sutured sites display similar early wound healing outcomes and patient-reported outcomes.

Wound‐healing agents for palatal donor area: A network meta‐analysis

“…Schinini et al. (2021) showed that sutured and non‐sutured sites treated with collagen hemostatic sponges display similar pain control. Inferior results in pain control were obtained with a collagen hemostatic sponge in comparison to Alvogyl in one study (Ehab et al., 2020).…”

“…In comparison to L-PRF, lower pain levels were obtained for L-PRF in comparison to collagen hemostatic sponge in three studies (Femminella et al, 2016;Hassan et al, 2020;Sousa et al, 2020), however, collagen hemostatic sponge promoted more less levels of pain in comparison to L-PRF in one case series (Belkhede et al, 2019). Schinini et al (2021) showed that sutured and non-sutured sites treated with collagen hemostatic sponges display similar pain control. Inferior results in pain control were obtained with a collagen hemostatic sponge in comparison to…”

“…In addition, collagen cones associated with gel based on recombinant human angiogenin promoted better repair in comparison to collagen cones alone (Goryachkin et al, 2019). Schinini et al (2021) showed that sutured and non-sutured sites treated with collagen hemostatic sponges display similar early woundhealing outcomes. Better wound healing was observed with collagen hemostatic sponge in comparison to spontaneous healing (Tavelli et al, 2018), however, better results were obtained when collagen hemostatic sponge was associated with cyanoacrylate adhesive (Tavelli et al, 2018(Tavelli et al, , 2019.…”

Effect of collagen sponge and flowable resin composite on pain management after free gingival graft harvesting: A randomized controlled clinical trial

“…This material has shown numerous advantages, providing mechanical protection and establishing a matrix for clot formation and organization [7,17]. In addition, the use of a collagen sponge decreases the time to achieve hemostasis of the palatal wound [7] and produces early healing of connective tissue graft donor sites [18]. Recently, studies of the postoperative pain following graft harvesting procedures have combined collagen sponges with other products, such as cyanoacrylate tissue adhesive, to enhance the effect.…”