Healing of colonic ischemic anastomoses in the rat

García, J. García; Criado, Fco J. Garcia; Persona, M. A. Benito; Alonso, Alberto Gómez

doi:10.1007/bf02235374

Cited by 23 publications

(18 citation statements)

References 11 publications

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“…After gastrointestinal surgery, many instances of leakage during clinical situations (tension sutures and excessive devascularization of the ends) exhibit hypoperfusion of anastomoses. If the degree of hypoxia is enough to interfere with tissue viability, then tissues necrose, thereby resulting in delayed wound healing [5]. Ischemic wounds heal poorly and infect easily.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study)

Adaş

Arıkan²,

Karatepe

et al. 2010

Langenbecks Arch Surg

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Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study)

Adaş

Arıkan²,

Karatepe

et al. 2010

Langenbecks Arch Surg

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“…As the surgical techniques and the suture materials, other factors interfere in anastomosis quality, as antibiotics 4,5 , antioxidants 6,7 , antineoplasics 8 , imunossupressors 9 , hormones 10 , trauma 11 , shock [12][13][14] , adherences 15,16 and ischemia 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

et al. 2010

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Purpose:To analyze the effects of hyperbaric oxygen therapy (HBO) on the mechanical resistance of anastomosis performed in rats' distal colon presenting peritonitis induced by ligature and cecal punction using the Total Energy Rupture biomechanical test (ETR). Methods: It was used 45 rats divided into three groups of 15 animals each. In Control Group (CG), it was performed anastomosis in distal colon without peritonitis. In Peritonitis Group (PG), it was performed anastomosis six hours after the induction of peritonitis by ligature and cecal punction. In Hyperbaric Chamber Group (HCG), it was performed six hours after the induction of peritonitis by ligature and cecal punction. The animals on CG and PG were kept at place air while the animals on HCG were placed on an experimental hyperbaric chamber in order to inhale oxygen at 100%, two absolute atmospheres, for 120 minutes, for four consecutive days. Euthanasia took place on the fifth day of the experiment. All the animals underwent to Total Energy Rupture Biomechanical Resistance test (ETR). Total Energy Rupture was defined as the necessary internal energy stored up to promote the colon rupture after an external traction force imposition. Results: The Peritonitis Group presents smaller average ETR than Control Group. There was no statistical difference between Peritonitis Group and Hyberbaric Chamber Group. Conclusion: Hyperbaric oxygen therapy did not alter the mechanical resistance of anastomosis performed in distal colon of rats under the presence of peritonitis induced by ligature and cecal puncture. Key words: Anastomosis, Surgical. Colon. Hyperbaric Oxygenation. Peritonitis. Rats. RESUMO Objetivo:Analisar o efeito da oxigenoterapia hiperbárica (HBO) sobre a resistência mecânica de anastomoses realizadas em cólon distal de ratos na presença de peritonite induzida por ligadura e punção cecal utilizando o teste biomecânico de Energia Total de Ruptura (ETR). Métodos: Foram utilizados 45 ratos distribuídos em três grupos de 15 animais. No Grupo Controle (GC), realizou-se anastomose no cólon distal sem peritonite. No Grupo Peritonite (GP), realizou-se anastomose seis horas após a indução da peritonite por ligadura e punção cecal. No Grupo Câmara Hiperbárica (GCH), realizou-se anastomose seis horas após a indução da peritonite por ligadura e punção cecal. Os animais dos GC e GP foram mantidos em ar ambiente. Os animais do GCH foram colocados em uma câmara hiperbárica experimental para inalarem oxigênio a 100%, a duas atmosferas absolutas, durante 120 minutos, por quatro dias consecutivos. A eutanásia ocorreu no quinto dia do experimento. Todos os animais foram submetidos ao Teste de Resistência Biomecânico Energia Total de Ruptura (ETR). A Energia Total de Ruptura foi definida como a energia interna acumulada necessária para promover o rompimento do cólon após a imposição de uma força externa de tração. Resultados: O Grupo Peritonite apresentou menor média de ETR que o Grupo Controle. Não houve diferença estatística entre o Grupo Peritonite e o Grupo C...

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“…Therefore, the anastomosis became relatively ischemic without complete necrosis of the intestine tissue. [9][10][11] The abdomen was then closed with sutures of 3-0 silk. All rats were euthanized on postoperative day 4.…”

Section: Surgical Proceduresmentioning

confidence: 99%

The effect of tadalafil on anastomotic healing in ischemic small intestine in rats

et al. 2010

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Healing of colonic ischemic anastomoses in the rat

Abstract: Superoxide radicals are involved in the delay in healing of ischemic anastomoses. Allopurinol lowers superoxide anion production and has beneficial effects on the cicatrization of ischemic anastomoses.

Cited by 23 publications

References 11 publications

Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study)

Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study)

Hyperbaric oxygen therapy and mechanical resistence of the colonics anastomosis in rats with peritonitis

The effect of tadalafil on anastomotic healing in ischemic small intestine in rats

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