Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism <scp><i>HFE</i> H63D</scp> with the strength of compression treatment—A re‐analysis of patients from previous studies

Blättler, W.; Lüscher, Dieter; Brizzio, E. O.; Willenberg, Torsten; Baumgartner, Iris; Amsler, Felix

doi:10.1111/j.1524-475x.2011.00752.x

Cited by 3 publications

(7 citation statements)

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“…Sokolova et al 22 identified a borderline reduced risk of those with p.H63D having VLUs, and Yang et al 19 concluded that iron status had a significant causal effect on the vascular disease of varicose veins in the lower extremities. In one secondary analysis, HFE gene variant carriers had a smaller proportion of healing of VLUs and a longer time to healing, which was impaired by high-strength compression 20 . A further systematic review of 38 studies concluded that the HFE p.C282Y variant was linked to a sevenfold increased risk of VLU 17 …”

Section: Results: Literature Reviewmentioning

confidence: 98%

“…Three studies investigated a range of gene polymorphisms, 9,17,18 and one evaluated iron status 19 with the endpoints of CVD (including varicose veins) and VLUs. Five studies investigated the specific gene polymorphisms for HFE (p.C282Y and p.H63D) with endpoints of CVD (including varicose veins) and VLUs 11,12,20–22 . The majority of studies were of moderate or high quality 9,11,12,18,19,21,22 …”

Section: Results: Literature Reviewmentioning

confidence: 99%

“…Five studies investigated the specific gene polymorphisms for HFE (p.C282Y and p.H63D) with endpoints of CVD (including varicose veins) and VLUs. 11,12,[20][21][22] The majority of studies were of moderate or high quality. 9,11,12,18,19,21,22 Results from a meta-analysis with a large number of participants (five studies on venous disease including 1,279 cases and 2,506 controls) did not show any significant association between HFE genotypes and venous disease; 21 however, analysis from two case-control studies (N = 638 and N = 1,227) found a significant relationship between overall risk for CVD (including varicose veins) and the HFE p.C282Y variant.…”

Section: Results: Literature Reviewmentioning

confidence: 99%

“…For clinical management of people with venous disease and hemochromatosis, Blättler et al 20 hypothesized that removal of toxic iron deposits from the interstitial space—a macrophage-dependent, time-consuming process—appears susceptible to environmental changes produced by high strength compression. Further research is essential because current criterion-standard treatment involves high-level compression for VLUs and would be contradictory to all current evidence-based guidelines.…”

Section: Discussionmentioning

confidence: 99%

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Exploring the Association between Hemochromatosis and Lower-Limb Venous Disease

Parker,

Finlayson,

Hall

et al. 2024

Adv Skin Wound Care

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OBJECTIVE Chronic venous disease is a circulatory system dysfunction that has the potential to lead to venous leg ulceration. Although research on the influence of specific gene variants on chronic venous disease has been limited, a few studies have reported an association between hemochromatosis and chronic venous disease. However, no studies have looked at the prevalence of lower-limb venous disease and leg ulcers in people with hemochromatosis. This study aimed to review the existing literature for any association between venous disease and hemochromatosis and investigate the prevalence of venous disease and leg ulcers in people with hemochromatosis. METHODS Scoping systematic literature review and cross-sectional study surveying people with hemochromatosis. RESULTS This scoping systematic literature review included nine articles and indicated a link between hemochromatosis and venous disease/leg ulcers, although further studies are needed to support this link. Analysis of survey results from people with hemochromatosis found a 9.2% prevalence of leg ulcers in those with self-reported hemochromatosis, considerably higher than the 1% to 3% expected, suggesting that hemochromatosis gene variants may be associated with the pathogenesis of chronic venous disease and leg ulcers. CONCLUSIONS This is the first known study to complete a review of the literature regarding hemochromatosis and venous leg ulcers and document the association between hemochromatosis and venous disease/leg ulcers. There is a lack of research in this area and hence limited evidence to guide practice.

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Section: Results: Literature Reviewmentioning

confidence: 98%

Section: Results: Literature Reviewmentioning

confidence: 99%

Section: Results: Literature Reviewmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Exploring the Association between Hemochromatosis and Lower-Limb Venous Disease

Parker,

Finlayson,

Hall

et al. 2024

Adv Skin Wound Care

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“…15 Our aim was to study the effect of liposomated bovine Lactoferrin, locally applied on the surface of UHD, in 9 patients with long-lasting evolution of refractory CVI, selected from our previous study, 16 and to evaluate its potential relation to the iron metabolism profile and mutations of HH genes. 17 …”

Section: Introductionmentioning

confidence: 99%

Ulcerated hemosiderinic dyschromia and iron deposits within lower limbs treated with a topical application of biological chelator

Brizzio¹,

Castro

Narbaitz

et al. 2012

Veins and Lymphatics

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The ulcerative haemosiderinic dyschromia of chronic venous insufficiency is difficult to heal and presents a high accumulation of iron. Lactoferrin, a potent natural iron chelator, could help to scar this ulcerative haemosiderinic dyschromia. The objective of this study was to determine whether the topical application of a liposomal gel with Lactoferrin favors scarring/degradation of the brown colored spot typical of ulcerative haemosiderinic dyschromia. Nine patients with severe chronic venous insufficiency and ulcerative haemosiderinic dyschromia (CEAP-C6), with a natural evolution of over 12 months, were included in the study. Hemo chromatosis gene mutations were investigated. The levels of serum ferritin, transferrin saturation and blood cell counts were analyzed. The presence of hemosiderin was investigated through periulcerous and ulcer fundus biopsies carried out at baseline and 30 days after treatment with Lactoferrin. The severity of the injuries (CEAP classification) was evaluated at the beginning of and throughout the whole 3-month treatment period. No patient had received compression treatment during the three months previous to this therapy. Significant improvement in these injuries, with a reduction in the dimensions of the brown spot (9 of 9) at Day 90, and complete scarring with a closure time ranging from 15 to 180 days (7 of 9) were observed. The use of topical lactoferrin is a non-invasive therapeutic tool that favors clearance of hemosiderinic dyschromia and scarring of the ulcer. The success of this study was not influenced either by the hemochromatosis genetics or the iron metabolism profile observed.

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