Healing of Burns after Treatment with 670Nanometer Low-Power Laser Light

Schlager, Andreas; Oehler, Kurt; Huebner, Kai-Udo; Schmuth, Matthias; Spoetl, Ludwig

doi:10.1097/00006534-200004050-00006

Cited by 57 publications

(51 citation statements)

References 18 publications

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“…While some reports show encouraging experimental and clinical data, other investigators found no improvement in wound healing processes and were not able to reproduce the above-mentioned effects after light irradiation [4,7,13,19,20].…”

Section: Discussionmentioning

confidence: 96%

“…In contrast, Hunter et al were unable to demonstrate a clinically significant acceleration of wound healing in partial thickness wounds of pigs treated with laser therapy [7]. Other investigators were also unable to reproduce the above-mentioned therapeutic effects in wound healing processes [4,13,19,20].…”

Section: Discussionmentioning

confidence: 98%

“…However, despite several promising reports (often in experimental studies), other investigators were unable to find an improvement in wound healing; the real benefits of low-power lasers and light therapy in clinical wound healing are still controversial [4,7,19,20].…”

Section: Introductionmentioning

confidence: 99%

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The effect of polarized light on wound healing

et al. 2001

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Recent investigations have reported contradictory results on the influence of low-power lasers and polarized light on wound healing. Different biologic effects have been observed after light irradiation but the real benefits of phototherapy in the healing of wounds in patients are still controversial. This article reports on a randomized, prospective single blind study that was set up to evaluate the effect of polarized light (wave length 400-2000 nm, degree of polarization >95%, power density 40 mW/cm 2 , light energy 2.4 J/cm 2 ) on the healing of standardized wounds. Twenty pairs of identical donor areas of split thickness skin grafts, taken on a similar location on each of the 20 patients, were treated according to an identical wound care protocol. The only difference was that one side was treated with polarized light and the other side without. The healing of these paired wounds was evaluated in a standardized manner and on a daily basis by two independent and blinded observers. The parameters assessed were: the degree of epithelialization, the quality of the granulation tissue, the degree of inflammation, the degree of infection, the aspect of the early scar tissue, blister formation, and the subjective feeling of the patient. Every parameter was scored on a 1-5 scale, with score 1 for the worst and score 5 for the best outcome. Long-term follow-up was performed after 1 month, 3 months, 6 months and 1 year. For all variables, except for infection and blister formation which was not seen in either group, highly significantly better scores were obtained in the donor sites treated with polarized light. Inter-observer agreement was acceptable to very good in all outcome variables. The results of this study demonstrated that polarized light had a beneficial effect on the healing of these standardized wounds, resulting in a faster epithelialization and an improved quality of early scar tissue formation.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

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The effect of polarized light on wound healing

et al. 2001

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“…This system is basically dependent on specific selected parameters which are: the inflammatory cells, the collagen deposition, the angiogenesis and the granulation tissue (Table 1) [10,27,28]. The extent of collagen deposition was qualitatively evaluated by MT stain, while the other parameters were qualitatively assessed using H&E stained sections.…”

Section: Morphometric Studymentioning

confidence: 99%

Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study

Hamid¹,

Soliman²

2015

J Histol Histopathol

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Background: Skin burn is common universal problem that may lead to ugly scarring, serious handicapping. Availability of natural biological treatment to improve its outcome becomes concern of many researchers. Aim of study: To explore the effect of aloe vera on the angiogenesis process during healing of a fullthickness experimental skin burn. Materials and methods: Seventy rats were divided into three groups; control group (A), group B and group C. Group B was exposed to full-thickness (FT) skin burn. Group C was exposed to FT skin burn with application of local aloe vera (AV) gel. Each of group B and C was divided into 3 subgroups from which skin specimens were taken at 4,8,12 days. Skin specimenswere prepared for histological and immunohistochemical study by hematoxlyin and eosin (H&E), Masson`s trichrome (MT) and alpha smooth muscle actin (α-SMA). All data were measured morphometrically and statistically analyzed. Results: After 4 days from inducing FT burn, the initial necrosis and inflammation gradually replaced by increased granulation tissue (GT) on 8 th and 12 th day skin specimens. The collagen deposition of GT increased progressively to make a coarse dense bundles, meanwhile the newly formed capillaries (NFC) of GT were surrounded by pericytes that showed extensive expression of α-SMA early on 4 th and till 8 th day specimens and decreased on 12 th day specimens. AV-treated groups showed relative decrease of α-SMA detection especially in 8 th and 12 th day specimens together with a significant decrease in the inflammatory infiltrate in all phases as well as deposition of more mature and finer collagen fibers compared with burn per se specimens. Conclusion: In full-thickness skin burn, aloe vera shows a beneficial effect by reducing the inflammation significantly and providing a more mature granulation tissue which could accelerate healing and might produce a sound well-remodeled scar.

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“…Rats in the two laser-treated groups (n = 15 each) were exposed daily to 38.2 J/cm 2 or 76.4 J/cm 2 LLLT, respectively, from day 1 after burning until the experimental time period was completed. The burned tissues daily received a certain amount of laser energy [12][13][14][29][30][31] during the wound healing process in order to increase reparative activities. The specifications of the laser (manufactured by Iranian Atomic Energy Agency; Tehran, Iran) are shown in the Table. To apply the laser treatment, we divided the burned area into several equal squares (1 × 1 cm).…”

Section: Study Groupsmentioning

confidence: 99%

Effects of low-level laser therapy on mast cell number and degranulation

Bayat

Vasheghani²,

Razavie³

et al. 2008

JRRD

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Abstract-Mast cells have been shown to participate in the wound healing process. We investigated the effects of low-level laser therapy (LLLT) on mast cell number in the inflammation, proliferation, and remodeling phases of the wound healing process of experimental burns. Sixty rats subjected to third-degree burns were divided into four groups: two laser-treated, one control, and one nitrofurazone-treated group. In the two lasertreated groups, burned areas received LLLT with a helium-neon laser at energy densities of 38.2 J/cm 2 and 76.4 J/cm 2 , respectively. The effects on mast cell number and degranulation were assessed 7, 16, and 30 days postburn (inflammation, proliferation, and remodeling phases of wound healing, respectively). Intact and degranulated mast cells were counted. Five rats with no burns were used for baseline studies. On day 7 in the first laser group, the total number of mast cells was significantly higher than in the other groups. On day 16 in the nitrofurazonetreated group, the total number of mast cells was significantly higher than in the control, first laser, and normal groups. LLLT on the experimental third-degree burns significantly increased the total number of mast cells during the inflammation phase of wound healing; also, topical application of 0.2% nitrofurazone ointment on the same burns significantly increased the total number of mast cells during the proliferation phase of burn healing.

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Healing of Burns after Treatment with 670Nanometer Low-Power Laser Light

Cited by 57 publications

References 18 publications

The effect of polarized light on wound healing

The effect of polarized light on wound healing

Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study

Effects of low-level laser therapy on mast cell number and degranulation

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