Healing Large Traumatic Eardrum Perforations in Humans Using Fibroblast Growth Factor Applied Directly or via Gelfoam

Comparative study on the effects of EGF and bFGF on the healing of human large traumatic perforations of the tympanic membrane

“…The side effects of EGF and bFGF have been extensively investigated; studies have shown no side effects related to the middle or inner ear . Although the rate of otorrhea in the two treatment groups was higher than in the observation group, the rate of purulent otorrhea was not significantly different between the groups.…”

“…These techniques have produced inconsistent results. More recent strategies have involved growth accelerators, such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and hyaluronic acid, with significant success. We previously compared the closure rates for large acute perforations in humans using edge approximation, observation only, and bFGF, and found a significant increase in the closure rate and shortening of the closure time for bFGF‐treated ears versus edge approximation and observation only, which were not significantly different.…”

Topical application of epidermal growth factor with no scaffold material on the healing of human traumatic tympanic membrane perforations

“…To restore patient quality of life more quickly, a few otologists suggest that early myringoplasty accelerates the closure of TMPs In recent years, polypeptide growth factors (e.g. basic fibroblast growth factor, bFGF, and epidermal growth factor, EGF) have been used frequently to repair experimental and clinical TMPs with satisfactory results …”

The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations

“…To promote closure of traumatic TMPs, some otolaryngologists prefer immediate application of invasive microsurgical procedures, Other studies have suggested in recent years that topical application of exogenous growth factors can accelerate eardrum healing and improve the closure rate . Nevertheless, topical application of growth factors could be restricted in some countries because of ethical concerns associated with drug treatments.…”