Healing Effect of Subcutaneous Administration of Granulocyte Colony-Stimulating Factor on Acute Rotator Cuff Injury in a Rat Model

Kobayashi, Yusuke; Kida, Yoshikazu; Kabuto, Yukichi; Morihara, Toru; Sukenari, Tsuyoshi; Nakagawa, Hidekazu; Onishi, Okihiro; Oda, Ryo; Kida, Noriyuki; Tanida, Takashi; Matsuda, Ken; Tanaka, Masaki; Takahashi, Kenji

doi:10.1089/ten.tea.2020.0239.a

Cited by 2 publications

(3 citation statements)

References 45 publications

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“…G-CSF is a cytokine that mobilizes bone marrow-derived cells (BM-DCs) to peripheral blood. A study suggested that injection of G-CSF to promote BM-DC release in the target area, i.e., rotator cuff, effectively enhanced rotator cuff healing by promoting tenocyte and cartilage matrix production [ 61 ]. Wright et al presented a study that confirmed skeletal muscle damage, including muscle damage following strenuous exercise, induced an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies—Proof of Concept

Reis

Lopes

Sousa

et al. 2023

Animals

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Tendon and ligament injuries are frequent in sport horses and humans, and such injuries represent a significant therapeutic challenge. Tissue regeneration and function recovery are the paramount goals of tendon and ligament lesion management. Nowadays, several regenerative treatments are being developed, based on the use of stem cell and stem cell-based therapies. In the present study, the preparation of equine synovial membrane mesenchymal stem cells (eSM-MSCs) is described for clinical use, collection, transport, isolation, differentiation, characterization, and application. These cells are fibroblast-like and grow in clusters. They retain osteogenic, chondrogenic, and adipogenic differentiation potential. We present 16 clinical cases of tendonitis and desmitis, treated with allogenic eSM-MSCs and autologous serum, and we also include their evaluation, treatment, and follow-up. The concerns associated with the use of autologous serum as a vehicle are related to a reduced immunogenic response after the administration of this therapeutic combination, as well as the pro-regenerative effects from the growth factors and immunoglobulins that are part of its constitution. Most of the cases (14/16) healed in 30 days and presented good outcomes. Treatment of tendon and ligament lesions with a mixture of eSM-MSCs and autologous serum appears to be a promising clinical option for this category of lesions in equine patients.

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Section: Discussionmentioning

confidence: 99%

Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies—Proof of Concept

Reis

Lopes

Sousa

et al. 2023

Animals

View full text Add to dashboard Cite

show abstract

“…2 ). Then, the signal intensity of each site was quantified and used in the SNQ value formula as follows: SNQ value = (signal intensity of ACL graft − signal intensity of quadriceps femoris tendon) / background signal intensity 8 , 13 . Two physicians participated in the MRI measurements of the grafts.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore, it is believed that the inward growth of a new bone is essential to ensure a firm graft‐to‐bone fixation. Interestingly, many bone inducible growth factors have been tested to achieve this goal, such as transforming growth factor‐β 11 , bone morphogenetic protein 12 , and granulocyte colony‐stimulating factor 13 .…”

Section: Introductionmentioning

confidence: 99%

Effects of Platelet‐Rich Plasma on Tendon‐Bone Healing After Anterior Cruciate Ligament Reconstruction

Chen

Zhu

et al. 2021

Orthopaedic Surgery

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Objective: To investigate the effect of platelet-rich plasma on tendon-bone healing after anterior cruciate ligament reconstruction.Methods: This retrospective study included 85 patients (range, 18-50 years; mean age, 33.95 AE 10.53 years; male/female, 49/36) who underwent anterior cruciate ligament reconstruction using autologous hamstring tendons between August 2017 and June 2019 at our institute. The participants in the study group (n = 42) were injected with platelet-rich plasma at both ends of the tendon graft, while those in the control group (n = 43) received an injection of normal saline. Magnetic resonance imaging signal/noise quotient values of the femoral and tibial ends, knee Lysholm scores, and International Knee Documentation Committee scores were compared at 3, 6, and 12 months postoperatively. Results:The signal/noise quotient values of the femoral and tibial ends in both groups were higher at 6 months than at 3 and 12 months postoperatively. The signal/noise quotient values of the tibial end were significantly lower in the platelet-rich plasma group than in the normal saline group at all follow-up time points (P < 0.05). The signal/noise quotient values of the tibial and femoral ends in both groups were significantly different at 3, 6, and 12 months postoperatively (P < 0.05). Additionally, the signal/noise quotient values of the tibia were significantly lower than those of the femur in both groups (P < 0.05). The Lysholm and International Knee Documentation Committee scores were significantly better in the platelet-rich plasma group than in the normal saline group only at 3 months postoperatively. No complications, such as knee joint infection or vascular and nerve injuries, occurred in any of the 85 patients. The knee flexion of all patients were more than 90 , and the straight degree was 0 . No joint stiffness was observed in all patients. Conclusion:Platelet-rich plasma can promote tendon-bone healing in grafts and can improve early postoperative knee joint function.

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Healing Effect of Subcutaneous Administration of Granulocyte Colony-Stimulating Factor on Acute Rotator Cuff Injury in a Rat Model

Cited by 2 publications

References 45 publications

Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies—Proof of Concept

Allogenic Synovia-Derived Mesenchymal Stem Cells for Treatment of Equine Tendinopathies and Desmopathies—Proof of Concept

Effects of Platelet‐Rich Plasma on Tendon‐Bone Healing After Anterior Cruciate Ligament Reconstruction

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