Heads and Tails: Requirements for Informative and Robust Computational Measures of Sperm Motility

Cupples, Gemma; Gallagher, Meurig Thomas; Smith, D. J.; Kirkman-Brown, Jackson

doi:10.1007/978-3-030-66292-9_21

Cited by 1 publication

(2 citation statements)

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“…53 Such systems are sensitive to acquisition parameters and underlying algorithms; so, care must be taken to compare analysis results between devices. 21 While the number of rapid progressive sperm may be predictive of treatment outcome, most CASA measurements of sperm have limited prognostic power. 54 An alternative approach, tracking the rapidly beating sperm flagellum, 55 has been highlighted by the WHO as having potential due to its physiological link to function.…”

Section: Before Selection—optimize the Populationmentioning

confidence: 99%

“…There are an increasing number of advanced examinations for sperm, 8 15 comprising tests such as DNA quality and fragmentation, 16 17 multiparametric sperm assessment, 18 and computer-aided sperm analysis. 19 20 21 There have been several calls for some of these examinations, most notably DNA fragmentation, to become part of standard sperm analysis. However, we believe that there is a way to go before these assessments reach the thresholds required to be considered as routine.…”

Section: Before Treatment—optimize the Manmentioning

confidence: 99%

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Only the Best of the Bunch—Sperm Preparation Is Not Just about Numbers

Gallagher,

Krasauskaite,

Kirkman-Brown

2023

Semin Reprod Med

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In this Seminar, we present an overview of the current and emerging methods and technologies for optimizing the man and the sperm sample for fertility treatment. We argue that sperms are the secret to success, and that there are many avenues for improving both treatment and basic understanding of their role in outcomes. These outcomes encompass not just whether treatment is successful or not, but the wider intergenerational health of the offspring. We discuss outstanding challenges and opportunities of new technologies such as microfluidics and artificial intelligence, including potential pitfalls and advantages. This article aims to provide a comprehensive overview of the importance of sperm in fertility treatment and suggests future directions for research and innovation.

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