Headless hemagglutinin-containing influenza viral particles direct immune responses toward more conserved epitopes
Cait E. Hamele,
Zhaochen Luo,
Rebecca A. Leonard
et al.
Abstract:Seasonal influenza vaccines provide mostly strain-specific protection due to the elicitation of antibody responses focused on evolutionarily plastic antigenic sites in the hemagglutinin head domain. To direct the humoral response toward more conserved epitopes, we generated an influenza virus particle where the full-length hemagglutinin protein was replaced with a membrane-anchored, “headless” variant while retaining the normal complement of other viral structural proteins such as the neuraminidase as well as … Show more
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