Headache with SARS‐CoV‐2 infection: A matter of concern

Dearing, Lukas; Müller, Felix; Sellner, Johann

doi:10.1111/ene.15084

Cited by 3 publications

(1 citation statement)

References 5 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, limited knowledge exists regarding the clinical spectrum and predisposing factors of persistent headache following . Some patients with persistent headache had a pre-existing primary headache syndrome and that SARS-CoV-2 infection may have triggered exacerbation or chronicity of the cephalic syndrome [13,14]. However, a subgroup may develop new daily persistent headache (NDPH), a treatment-refractory primary headache syndrome [12,15].NDPH is characterized by daily headache persisting for more than three months in individuals without a previous history of headache [16].…”

mentioning

confidence: 99%

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross- sectional study

Carrión-Nessi,

Ascanio,

Pineda-Arapé

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Persistent headache is a frequent symptom after coronavirus disease 2019 (COVID-19) and there is currently limited knowledge about its clinical spectrum and predisposing factors. A subset of patients may be experiencing new daily persistent headache (NDPH) after COVID-19, which is among the most treatment-refractory primary headache syndromes.Methods We conducted a cross-sectional study in Latin America to characterize individuals with persistent headache after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and identify risk factors associated with NDPH. Participants over 18 years old who tested positive for SARS-CoV-2 infection and reported persistent headache among their symptoms completed an online survey that included demographics, past medical history, persistent headache clinical characteristics, and COVID-19 vaccination status. Based on participants’ responses, NDPH diagnostic criteria were used to group participants into NDPH and non-NDPH groups.Results Four hundred and twenty-one participants from 11 Latin American countries met the inclusion criteria. One in four participants met the diagnostic criteria for NDPH. The mean age was 40 years, with most participants being female (82%). Over 90% of the participants reported having had mild/moderate COVID-19. Most participants had a history of headache before developing COVID-19 (58%), mainly migraine type (32%). The most predominant clinical characteristics in the NDPH group were occipital location, severe/unbearable intensity, burning character, and radiating pain (p < 0.05). A higher proportion of anxiety symptoms, sleep problems, myalgia, mental fog, paresthesia, nausea, sweating of the face or forehead, and ageusia or hypogeusia as concomitant symptoms were reported in participants with NDPH (p < 0.05). Palpebral edema as a concomitant symptom during the acute phase of COVID-19, occipital location, and burning character of the headache were risk factors associated with NDPH.Conclusion This is the first study in Latin America that explored the clinical spectrum of NDPH after SARS-CoV-2 infection and its risk factors. Clinical evaluation of COVID-19 patients presenting with persistent headache should take into consideration NDPH.

show abstract

mentioning

confidence: 99%

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross- sectional study

Carrión-Nessi,

Ascanio,

Pineda-Arapé

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Headache as a COVID-19 onset symptom or Post-COVID symptom according to the SARS-CoV-2 Variant

Fernández‐de‐las‐Peñas

Cuadrado

Gómez‐Mayordomo³

et al. 2023

Expert Review of Neurotherapeutics

View full text Add to dashboard Cite

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross-sectional study

Carrión-Nessi,

Ascanio,

Pineda-Arapé

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

Background Persistent headache is a frequent symptom after coronavirus disease 2019 (COVID-19) and there is currently limited knowledge about its clinical spectrum and predisposing factors. A subset of patients may be experiencing new daily persistent headache (NDPH) after COVID-19, which is among the most treatment-refractory primary headache syndromes. Methods We conducted a cross-sectional study in Latin America to characterize individuals with persistent headache after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to identify factors associated with NDPH. Participants over 18 years old who tested positive for SARS-CoV-2 infection and reported persistent headache among their symptoms completed an online survey that included demographics, past medical history, persistent headache clinical characteristics, and COVID-19 vaccination status. Based on participants’ responses, NDPH diagnostic criteria were used to group participants into NDPH and non-NDPH groups. Participant data was summarized by descriptive statistics. Student’s t and Mann–Whitney U tests were used according to the distribution of quantitative variables. For categorical variables, Pearson’s chi-square and Fisher’s exact tests were used according to the size of expected frequencies. Binomial logistic regression using the backward stepwise selection method was performed to identify factors associated with NDPH. Results Four hundred and twenty-one participants from 11 Latin American countries met the inclusion criteria. One in four participants met the NDPH diagnostic criteria. The mean age was 40 years, with most participants being female (82%). Over 90% of the participants reported having had mild/moderate COVID-19. Most participants had a history of headache before developing COVID-19 (58%), mainly migraine type (32%). The most predominant clinical characteristics in the NDPH group were occipital location, severe/unbearable intensity, burning character, and radiating pain (p < 0.05). A higher proportion of anxiety symptoms, sleep problems, myalgia, mental fog, paresthesia, nausea, sweating of the face or forehead, and ageusia or hypogeusia as concomitant symptoms were reported in participants with NDPH (p < 0.05). Palpebral edema as a concomitant symptom during the acute phase of COVID-19, occipital location, and burning character of the headache were risk factors associated with NDPH. Conclusion This is the first study in Latin America that explored the clinical spectrum of NDPH after SARS-CoV-2 infection and its associated factors. Clinical evaluation of COVID-19 patients presenting with persistent headache should take into consideration NDPH.

show abstract

Headache with SARS‐CoV‐2 infection: A matter of concern

Cited by 3 publications

References 5 publications

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross- sectional study

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross- sectional study

Headache as a COVID-19 onset symptom or Post-COVID symptom according to the SARS-CoV-2 Variant

New daily persistent headache after SARS-CoV-2 infection in Latin America: a cross-sectional study

Contact Info

Product

Resources

About