Headache‐type adverse effects of NO donors: vasodilation and beyond

Bagdy, György; Riba, Pál; Kecskeméti, Valéria; Chase, Diana; Juhász, Gabriella

doi:10.1111/j.1476-5381.2010.00643.x

Cited by 40 publications

(39 citation statements)

References 183 publications

(259 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the potentially severe side effects of glyceryl trinitrate overdose are related to its systemic vasodilator effect, which can cause hypotension and headaches (59,60). We therefore used blood pressure as the indicator for glyceryl trinitrate in vivo activity and to assess severe side effects.…”

Section: Discussionmentioning

confidence: 99%

Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Orjuela-Sánchez

Ong

Zaniní

et al. 2013

Antimicrob Agents Chemother

View full text Add to dashboard Cite

c Cerebral malaria (CM) is associated with low nitric oxide (NO) bioavailability, cerebrovascular constriction, occlusion, and hypoperfusion. Administration of exogenous NO partially prevents the neurological syndrome and associated vascular pathology in an experimental CM (ECM) mouse model. In this study, we evaluated the effects of transdermal glyceryl trinitrate in preventing ECM and, in combination with artemether, rescuing late-stage ECM mice from mortality. The glyceryl trinitrate and/or artemether effect on survival and clinical recovery was evaluated in C57BL/6 mice infected with P. berghei ANKA. NO synthase (NOS) expression in mouse brain was determined by Western blots. Mean arterial pressure (MAP) and pial arteriolar diameter were monitored using a tail-cuff blood pressure system and a cranial window preparation, respectively. Preventative administration of glyceryl trinitrate at 0.025 mg/h decreased ECM mortality from 67 to 11% and downregulated inducible NOS expression in the brain. When administered as adjunctive rescue therapy with artemether, glyceryl trinitrate increased survival from 47 to 79%. The adjunctive therapy caused a sustained reversal of pial arteriolar vasoconstriction in ECM mice, an effect not observed with artemether alone. Glyceryl trinitrate induced a 13% decrease in MAP in uninfected mice but did not further affect MAP in hypotensive ECM mice. Glyceryl trinitrate, when combined with artemether, was an effective adjunctive rescue treatment for ECM. This treatment ameliorated pial arteriolar vasospasm and did not significantly affect MAP. These results indicate that transdermal glyceryl trinitrate has potential to be considered as a candidate for adjunctive therapy for CM.

show abstract

Section: Discussionmentioning

confidence: 99%

Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Orjuela-Sánchez

Ong

Zaniní

et al. 2013

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Trigeminovascular system activation seems to be the key point for the initiation of migraine attacks. Therefore, NO may be involved in the initiation of a series of alterations, such as changes in the functions of ion channels, or calcitonin gene-related peptide (CGRP) or glutamate release that may result in migraine type headaches (14,15). CGRP is a significant molecule in this respect.…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma total nitrite levels may be related to migraine attacks

Neyal¹,

Geyik²,

Çekmen³

et al. 2014

Gaziantep Med J

View full text Add to dashboard Cite

Both vascular and neuronal mechanisms are the main foci of investigation in defining the pathophysiology of migraine attacks. This study was designed to evaluate the possible role of nitric oxide (NO) in migraine patients in the natural course of unprovoked attacks and attack-free periods. The mean plasma nitrite levels of 26 migraine patients during attacks and attack-free periods were compared within group and with those of 26 healthy controls. Plasma total nitrite levels were measured by Greiss reaction. Mean plasma total nitrite levels of migraine patients during attacks and attack-free periods and of controls were 36.5±7.5 μmol/l, 27.81±4.8 μmol/l and 25.19±4.1 μmol/l, respectively. These results demonstrated that total nitrite levels during attacks were significantly higher in migraineurs than both during attack-free periods and those of controls (P=0.001 and P=0.001, respectively). No significant difference was observed between migraineurs during attack-free periods and controls in this regard (P=0.534). Based on these results, we suggest that NO pathway may play a key role in the pathogenesis of migraine attacks.

show abstract

“…Mindkét betegség hátterében alapvető patofi ziológiai tényezők, például a fájdalomszabályozás, a peptiderg, a szerotonerg és a GABAerg rendszer vagy az ioncsatornák működésének a megváltozása áll [24]. Az akut és profi laktikus kezelésre is alkalmazott kalciumantagonista fl unarizin a betegek mintegy 8%-ában olyan súlyos depressziót okozott, ami a kezelés abbahagyását tette szükségessé [25], ezért csak második vonalbeli szernek alkalmazzák.…”

Section: Migrén Kezelésére Alkalmazott Gyógyszerekunclassified

Anxiogenic and depressogenic side-effects of non-psychiatric drugs

et al. 2013

View full text Add to dashboard Cite

Annak ellenére, hogy számos szomatikus betegség kezelésére alkalmazott -például daganatellenes, antimikrobás, immunmoduláns, neurológiai, illetve hormonháztartásra ható -gyógyszer hathat negatív irányban a hangulatra, ezt egészen a rimonabant 2008-ban emiatt történt visszavonásáig nem kezelték jelentőségének megfelelően. A szerzők a teljes gyógyszerpalettát áttekintve tárgyalják a szorongást és a depressziót, mint gyógyszer-mellékhatásokat. A gyógyszerválasztásnál minden esetben fi gyelembe kell venni, ha a betegeknél magas a depresszió kialakulásának a kockázata, például, ha már korábban előfordult vagy jelenleg is fennáll a depressziós epizód vagy betegség, ha a családi anamnézisben előfordul depresszió, illetve ha a betegnél olyan neurotikus személyiségvonások állnak fenn, amelyek következtében sérülékenyebb a depressziót kiváltó hatásokkal szemben. A veszélyt jelentő gyógyszerek felírása előtt emellett célszerű fi gyelembe venni az alkalmazni kívánt szer hatékonyságát, a rendelkezésre álló alternatív gyógyszeres és nem gyógyszeres terápiás lehetőségeket, és minden esetben biztosítani kell a beteg monitorozását a kezelés során az esetleges depressziós vagy szorongásos tünetek mihamarabbi észlelése érdekében. Orv. Hetil., 2013, 154, 1327-1336.Kulcsszavak: depresszió, pszichiátriai mellékhatások, rimonabant, gyógyszermellékhatás, személyre szabott orvoslás Anxiogenic and depressogenic side-effects of non-psychiatric drugsAlthough medications such as anticancer, antimicrobial, immunomodulatory, neurological or hormonal therapies may have a negative impact on mood, adequate attention was not paid until the withdrawal of rimonabant in 2008. In the present study the authors review full spectrum of currently available medications discussing anxiety and depression as possible adverse effects of treatment. A relatively high risk of depression should always be considered when pharmacotherapy applied, especially if current depressive episodes, positive family history, or neurotic personality traits increasing susceptibility to depressogenic effects. Prior to start of medical treatment, the potential effectiveness of the given drug should be precisely evaluated, and alternative medical and non-medical treatment options should also be carefully considered. In addition, monitoring patients during treatment for signs of depressive or anxious symptoms is necessary. Orv. Hetil., 2013, 154, 1327-1336

show abstract

Headache‐type adverse effects of NO donors: vasodilation and beyond

Cited by 40 publications

References 183 publications

Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Elevated plasma total nitrite levels may be related to migraine attacks

Anxiogenic and depressogenic side-effects of non-psychiatric drugs

Contact Info

Product

Resources

About