Headache immunology

Prishchepa, A. V.; Данилов, А. Б.

doi:10.17116/jnevro20171175194-102

Cited by 2 publications

(2 citation statements)

References 58 publications

(62 reference statements)

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“…Соблюдение здорового образа жизни включает [2,3] • повышение диастолического артериального давления [30]. Отмечается высокая коморбидность мигрени к заболеваниям, связанным с нарушением работы иммунной системы: экзема, бронхиальная астма, сезонная аллергия [31].…”

Section: соблюдение здорового образа жизниunclassified

Rehabilitation of patients with chronic headaches

Kadykov

Белопасова

Губанова

et al. 2020

Physical and rehabilitation medicine, medical rehabilitation

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The worldwide trend towards headache (HA) chronization is an important medical and social problem due to frequent psychological and social maladaptation of patients. Chronic HAs reduce quality of life and patients ability to work. The trend towards headache chronization is largely associated with acceleration of the pace of life, constant social and informational tension, leading to emotional disturbances, such as depression, anxiety, and asthenia. Single medical interventions do not seem to have a lasting effect. Thus, such patients require long-term comprehensive rehabilitation with regard to the type and characteristic features of HA, as well as triggers and comorbid condition. Rehabilitation should include adequate long-term drug therapy aimed at preventing exacerbations of HA. Additional approaches may include botulinum neurotoxin injections, physiotherapy (biofeedback, transcranial magnetic stimulation, transcranial electrical stimulation), psychotherapy, comorbid conditions diagnosis and treatment, lifestyle intervention.

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Section: соблюдение здорового образа жизниunclassified

Rehabilitation of patients with chronic headaches

Kadykov

Белопасова

Губанова

et al. 2020

Physical and rehabilitation medicine, medical rehabilitation

View full text Add to dashboard Cite

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“…In addition, the inflammatory conditions cause changes in serum levels of immune mediators in migraine patients but diverse results have been reported on the mechanisms involved (8)(9)(10)(11)(12). The interaction between immune cells is regulated by several mechanisms, including cytokines, which play a crucial role in physiological and pathological processes such as, Immunity, inflammation and pain (13). Widely, cytokines and their receptors are present in the central nervous system (CNS) and have been proposed as important inflammation mediators in neuro-vascular system and likely to be involved in pain threshold modulation (14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Investigation of association between CD40 current gene variants (rs4810485, rs1883832 and rs3765459) and serum CD154 protein levels in Iranian migraineurs

Ramroodi¹,

Saboori²,

Sanadgol³

2018

Cell Mol Biol (Noisy-le-grand)

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Migraine is a chronic neurological disease described by recurrent moderate to severe headaches often in association with neuro-inflammation. As cytokines are affect the immune response and migraine exacerbation, the current study aimed to investigate the possible associations between CD40 polymorphisms and level of soluble CD154 protein with migraine. In a prospective case-control study, we studied blood samples of 190 patients with migraine (migraineurs) and 200 healthy controls (HCs) from southeast Iran. Genotyping for the CD40 (rs4810485-intron, rs1883832-5´-UTR, and rs3765459-intron) gene variants were executed using PCR-RFLP and soluble CD154 protein levels were measured via ELISA method. Among CD40 gene variants, rs1883832 (TC genotype) was significantly associated with migraine (P = 0.007, OR = 2.326, 95% CI = 1.258-4.303). No significant associations observed between the rs4810485 and rs3765459 SNPs with migraine. The most frequent genotypes for CD40 were GG in rs4810485 (51.5%) and rs3765459 (62.1%) as well as TC in rs1883832 (53.7%). There was no statistically relationship between these gene variants and different subclasses of migraine. Concentration of soluble CD40L among patients with rs1883832 (TC genotype) were significantly (P = 0.027, OR = 0.417, CI = 0.192-0.906) higher in compared to healthy controls. Our findings showed that in CD40 rs1883832, TC genotype may have a role in migraine susceptibility. Therefore, it suggested that in addition to other factors, CD40 rs1883832 (TC genotype) genetic variation may also play a critical role in the etiology of migraine.

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Headache immunology

Cited by 2 publications

References 58 publications

Rehabilitation of patients with chronic headaches

Rehabilitation of patients with chronic headaches

Investigation of association between CD40 current gene variants (rs4810485, rs1883832 and rs3765459) and serum CD154 protein levels in Iranian migraineurs

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