Background: Lock down caused sudden lifestyle changes and represented a massive impact on human health. Environmental factors can trigger migraine headache. The aim of this study was to report the triggers of migraine attacks due to lifestyle changes during coronavirus disease 2019 (COVID-19) Pandemic lockdown. Methods: This cross-sectional survey included patients diagnosed as migraine according to The International Classification of Headache Disorders, 3rd edition (ICDH-3). During the lockdown, we submitted an online self-reported web-based questionnaire to patients already diagnosed with primary headache disorders and attends headache clinic at Ibn Sina Hospital in Kuwait. Questions explored triggers of migraine headache attacks during COVID-19 Pandemic lockdown. Answers were transformed into data for statistical analysis. Results: A total of 340 migraine patients responded to online questionnaire. The mean age of them is 34.65 years. Females were predominant 79.1%. Majority of the cohort 85 % has more than one trigger of migraine headache attack. The common triggers were smell of strong odors in 214 (62.9%), followed by certain food in 175 (51.8%), sleep disturbance in 120 (35.3%), Emotional or mental stress in 80 (23.6%), caffeine in 80 (23.6%), flickers of Light in 78 (22.9), weather changes in 68(20%), smoking in 65 (19.12), noise in 56 (16.5), sun light exposure in 41 (12.1), Fasting/ Hypoglycemia in 40 (11.7), hormonal changes in 37 (10.6%), physical excretion/fatigue in 24 (7.1), screen exposure in 20 (5.9%), and dehydration in 14 (4.1%).Conclusions: Lifestyle changes during lock down may negatively impact migraine through patients exposure to many triggers. Strong odors, food, sleep disturbance and stress were the most migraine triggers during COVID-19 lockdown.