Headache, cerebrovascular symptoms, and stroke

Stang, Paul; Carson, April P.; Rose, Kathryn M.; Mo, Jingping; Ephross, Sara A.; Shahar, Eyal; Szklo, Moysés

doi:10.1212/01.wnl.0000158326.31368.04

Cited by 220 publications

(181 citation statements)

References 29 publications

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“…The incidence of cerebro-and cardio-vascular events in the WHS are shown in Figure 2. Similar findings were achieved in the Atherosclerosis Risk in Communities Study (ARCS) [30], a randomized trial with a study population of 12,750 subjects of both sexes: patients with MA were found to have a 2.81 RR of ischemic stroke (95% CI: 1.6-4.92) and a 4.28 RR of transient ischemic attack (TIA) (95% CI: 3.02-6.08).The absolute increase of cerebrovascular risk is also limited for women in this age group, but is considerably greater than that of younger women: in the WHS study, 3.8 strokes per 10,000 persons-years could be attributed to MA [29].…”

Section: Association Between Migraine and Cerebrovascular Diseasessupporting

confidence: 73%

Migraine and Cardiocerebrovascular Risk in Women

Agostoni

Aliprandi²

2007

Womens Health (Lond Engl)

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The interest of the medical community has recently focused on the relationship between gender and cardiocerebrovascular risk. In this paper, we will first review gender differences in cardiocerebrovascular disorders, then we will discuss the existing evidence on the links between migraine and stroke and cardiovascular disease in women, and speculate on the possible physiopathological interpretations of this emerging epidemiological link. In the third part of this work, we will address the issue of the effect of sex hormones on vascular risk, and consider the evidence concerning the safety of oral contraceptives and hormone-replacement therapy. Finally, we will outline the main trends of future research and its possible clinical and therapeutic implications

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Section: Association Between Migraine and Cerebrovascular Diseasessupporting

confidence: 73%

Migraine and Cardiocerebrovascular Risk in Women

Agostoni

Aliprandi²

2007

Womens Health (Lond Engl)

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“…Several lines of evidence suggest MA is more strongly associated with stroke than MO [3,4,12]. For our study, analysis of associations between family history of vascular risk factors and MA compared to MO found only modest positive associations, with confidence intervals that included no associations at all.…”

Section: Discussioncontrasting

confidence: 42%

“…Data from several studies suggest that migraine may be a risk factor for the development of stroke [3,4,[9][10][11][12] and MA may be an important risk factor for stroke in women [12,13]. The mechanisms that underlie these observations are unclear but a reasonable hypothesis could include the presence of shared risk factors as a possible cause.…”

Section: Discussionmentioning

confidence: 99%

“…There appears to be a clear correlation between migraine and stroke or other cardiovascular events in rare genetic conditions such as cerebral autosomal dominant arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL), mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) and the familial dyslipoproteinaemias [2]. Association between the common forms of migraine, stroke and other vascular risk factors has been shown in several large population-based studies [3,4]. An increase in vascular events in parents and grandparents of children with migraine compared to control subjects has been documented previously [5].…”

Section: Introductionmentioning

confidence: 99%

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Clinic–based study of family history of vascular risk factors and migraine

et al. 2005

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The objective was to evaluate the presence of a positive family history (FH) of vascular risk factors between patients with migraine with aura (MA) and migraine without aura (MO), and in chronic migraine (CM) compared to other headache types. As migraine patients are typically too young to have developed vascular events, studying older relatives of migraine patients may be a practical means of evaluating associations between vascular risk factors and migraine. A cross-sectional study of a clinicbased sample of adults with migraine headache was carried out at the University of Utah. Predictor variables comprised first or second degree relatives with stroke, hypertension, diabetes or hypercholesterolaemia. Outcome measures comprised diagnosis of MA, MO or CM according to the revised International Headache Society criteria. There was no significant difference in FH of vascular risk factors in MA compared to MO (adjusted OR 1.04, 95% CI 0.61-1.78). CM was associated with a decreased risk of FH of stroke (OR=0.11, p=0.036). There was no significant difference in FH of vascular risk factors in MA patients compared to MO. CM patients were more likely to have a negative FH of stroke compared to other headache types, suggesting that CM is likely a neuronal disease rather than a vascular one.

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“…The second prospective study used data from the Atherosclerosis Risk in Communities Study and included over 12,000 men and women aged 55 and older 30 . Compared to participants without headaches, migraineurs (of both subtypes) had a 1.8-fold increased risk of ischemic stroke (relative risk 1.84; 95% CI, 0.89-3.82).…”

Section: Migraine and Strokementioning

confidence: 99%

Migraine and cardiovascular disease

Bigal

2011

Arq. Neuro-Psiquiatr.

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Migraine, especially migraine with aura is an established risk factor for ischemic lesions of the brain. Recent evidence has also linked migraine with and without aura to a broader range of ischemic vascular disorders including angina, myocardial infarction, coronary revascularization, claudication and cardiovascular mortality. The topic is therefore of considerable interest. Accordingly, herein we review the association between migraine and cardiovascular disease. We start by briefly presenting diagnostic criteria for migraine and revising its pathophysiology. We follow by summarizing the evidence on the topic. We then briefly present the results of a recent meta-analysis. We close by highlighting results of a large epidemiological study conducted after the publication of the meta-analysis. Key words: migraine, cardiovascular disease, stroke. Migrânea e doenças cardiovasculares RESUMOA migrânea, especialmente a migrânea com aura, é fator de risco para lesões cerebrais. Evidência recente sugere que migrânea com e sem aura é associada com outras doenças cardiovasculares isquêmicas, incluindo a angina, o infarto do miocárdio, revascularização coronária, claudicação e morte súbita. Iniciamos discutindo o diagnóstico da migrânea e seus mecanismos fisiopatológicos. Após sumarizar a evidência, discutimos resultados de meta-análise recente. Por fim, ressaltamos resultados de um grande estudo populacional sobre o assunto. Palavras-chave: migrânea, doença cardiovascular, acidente vascular cerebral.

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Headache, cerebrovascular symptoms, and stroke

Abstract: Migraines and other headaches, particularly those accompanied by aura, were associated with an increased occurrence of stroke/TIA symptoms and ischemic stroke events.

Cited by 220 publications

References 29 publications

Migraine and Cardiocerebrovascular Risk in Women

Migraine and Cardiocerebrovascular Risk in Women

Clinic–based study of family history of vascular risk factors and migraine

Migraine and cardiovascular disease

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