“…It is generally assumed that headaches involve the activation of intracranial afferents of the trigeminal nerve and/or the second order neurons in the spinal trigeminal nucleus, where these afferents are projecting to (Levy, Labastida-Ramirez, & MaassenVanDenBrink, 2018;Olesen, Burstein, Ashina, & Tfelt-Hansen, 2009;Schueler, Messlinger, Dux, Neuhuber, & Col, 2013). Headache and ocular pain are frequently associated (Dafer & Jay, 2009), and there is a close association between nasal/paranasal lesions and headaches (Pinto, Rossi, McQuone, & Sollecito, 2001;Silberstein, 2004). The effectivity of intranasal application of drugs for the treatment of headaches is supportive for this view (Rapoport, Bigal, Tepper, & Sheftell, 2004).…”