Headache and migraine during pregnancy and puerperium: the MIGRA-study

Kvisvik, Elisabeth Volden; Stovner, Lars Jacob; Helde, Grethe; Bovim, Gunnar; Linde, Mattias

doi:10.1007/s10194-011-0329-1

Cited by 121 publications

(91 citation statements)

References 27 publications

(66 reference statements)

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“…An interesting finding in this study was that the prevalence of migraine attacks without aura was high in the study subjects and did not subside during pregnancy. A recent study reported that women having migraine without aura are more likely to recover than women having migraine with aura (18), but this trend was not observed in our study. It is easy to understand that physical and social problems arising during pregnancy can play a role in the course of migraine during pregnancy.…”

Section: Discussioncontrasting

confidence: 56%

“…Most epidemiological studies demonstrated that pregnant women who experience headaches before pregnancy report to have a 55 -90% improvement in the severity of the attack after they become pregnant (15)(16)(17). A large-scale MIGRA study also revealed a significant decrease in the frequency of migraine during pregnancy (18). This could be attributed to stable levels of estrogen and progesterone, along with an increase in beta-endorphin.…”

Section: Discussionmentioning

confidence: 79%

“…This could be attributed to stable levels of estrogen and progesterone, along with an increase in beta-endorphin. Beta endorphin is known for its anti-nociceptive effect during pregnancy, which might be a possible reason for the changing course of migraine during pregnancy (18,19). An interesting finding in this study was that the prevalence of migraine attacks without aura was high in the study subjects and did not subside during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Association Between Migraine and Diabetes in Pregnancy

Zain¹,

Mustafa²,

Khan³

et al. 2016

Avicenna J Med Biochem

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Background: Migraine ranks as the eighth most disabling condition and one of the most common causes of headache in Pakistan. Objectives: In this study, we aimed to determine the association between migraine and diabetes in pregnant women. Patients and Methods:This cross-sectional study recruited 498 pregnant women, grouped into pregnant without diabetes (n = 300) and pregnant with diabetes (n = 198) according to the International Association of the Diabetes and Pregnancy Study criteria. Seventy-five women with known migraine were also recruited as positive controls. After confirming that the study subjects had headache at least once a month, the researcher filled out a comprehensive form based on the International Classification of Headache Disorders version II. Migraine disability score was used to assess severity. Fasting blood glucose levels were measured by

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Migraine and Diabetes in Pregnancy

Zain¹,

Mustafa²,

Khan³

et al. 2016

Avicenna J Med Biochem

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“…Migraine with aura seems to be less affected by pregnancy and menstruation. 94 Despite data supporting estrogen decline as a potential cause of menstrual migraine, the role of estrogen replacement therapy is not clear. The majority of women will have a reduction in menstrual migraine with estrogen therapy; however, in a minority of women estrogen therapy may be associated with increasing frequency of acute migraine attacks, more chronic migraine, and higher risk of stroke.…”

Section: Gender Differences In Treatmentmentioning

confidence: 99%

Gender Differences in Neurologic Emergencies Part I: A Consensus Summary and Research Agenda on Cerebrovascular Disease

Madsen

Seigel²,

Mackenzie

et al. 2014

Acad Emerg Med

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Cerebrovascular neurologic emergencies including ischemic and hemorrhagic stroke, subarachnoid hemorrhage (SAH), and migraine are leading causes of death and disability that are frequently diagnosed and treated in the emergency department (ED). Although sex and gender differences in neurologic emergencies are beginning to become clearer, there are many unanswered questions about how emergency physicians should incorporate sex and gender into their research initiatives, patient evaluations, and overall management plans for these conditions. After evaluating the existing gaps in the literature, a core group of ED researchers developed a draft of future research priorities. Participants in the 2014 Academic Emergency Medicine consensus conference neurologic emergencies working group then discussed and approved the recommended research agenda using a standardized nominal group technique. Recommendations for future research on the role of sex and gender in the diagnosis, treatment, and outcomes pertinent to ED providers are described for each of three diagnoses: stroke, SAH, and migraine. Recommended future research also includes investigation of the biologic and pathophysiologic differences between men and women with neurologic emergencies as they pertain to ED diagnoses and treatments.ACADEMIC EMERGENCY MEDICINE 2014;21:1403-1413 by the Society for Academic Emergency Medicine C erebrovascular neurologic emergencies such as ischemic and hemorrhagic stroke, subarachnoid hemorrhage (SAH), and migraine are among the most lethal and disabling conditions presenting to the emergency department (ED). We have made great strides in understanding and treating these conditions, and our efforts have led to improved outcomes for these patients. Sex-and gender-based distinctions, however, are only recently becoming clearer, and much work is needed to explain the differences observed between men and women. After a focused review of the current literature on preclinical, clinical, and outcomes differences between women and men, and then the consensus process, we propose a research agenda in the areas of stroke, SAH, and headache/migraine. METHODSAfter evaluating the current literature, the authors, all emergency medicine (EM) researchers, proposed an agenda for future research. Consensus was reached using an iterative process through the four-part nominal group technique as already described in the executive summary. 1 A multidisciplinary group of participants (EM, critical care medicine, internal medicine, physical and rehabilitation medicine) prioritized the final iteration of themes/questions using the Poll Everywhere Web-based voting method. Descriptive statistics were calculated to tabulate the final list of questions presented below. The proposed research questions were then discussed and voted on by participants in the Academic Emergency Medicine consensus conference neurologic emergencies working group (see footnote for listing) at the meeting in May 2014. STROKE Epidemiology/OutcomesStroke is the fourth leading ca...

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“…Lactation generally leads to an improvement in the clinical course of migraines during the postpartum period (7). However, few reports have so far focused on migraines during the postpartum period (10), and…”

Section: Introductionmentioning

confidence: 99%

Postpartum Migraines: A Long-term Prospective Study

et al. 2012

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Objective There are many reports regarding the course of migraines during pregnancy. However, the prevalence and characteristics of migraines during the postpartum period have not been adequately investigated. We prospectively investigated the patients suffering from migraines over a long postpartum period in an obstetrics department in Japan. Methods We investigated the course of migraines experienced during the postpartum period by patients in a postnatal ward. The patients were surveyed during the first postpartum week and 1, 3, 6 and 12 months after delivery. The patients were provided a headache diary to assess medication use and migraine attack frequency, severity (the faces pain scale) and duration. Results The migraine remission rate was 63%, 83% and 85% during the first, second and third trimesters, respectively. No patient experienced a worsening of headaches during pregnancy. Headache recurrence during the first month after delivery was more frequent in the patients >30 years of age than in those ! 30 years of age (p<0.05). The percentage of women experiencing recurrence at 1, 3, 6 and 12 months after delivery was 63%, 75%, 78% (n=60) and 87.5% (n=40), respectively. In breastfeeding patients, the rates were 50%, 65.8%, 71.1% and 91.7% and in bottle feeding patients, the rates were 86.4%, 90.9%, 95.5% and 81.3%, respectively. Conclusion We found that 85% of the patients with migraines experience remission during pregnancy and that more than 50% experience recurrence during the first month after delivery. Until six months after delivery, breastfeeding is associated with a lower recurrence rate than bottle feeding.

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Headache and migraine during pregnancy and puerperium: the MIGRA-study

Cited by 121 publications

References 27 publications

Association Between Migraine and Diabetes in Pregnancy

Association Between Migraine and Diabetes in Pregnancy

Gender Differences in Neurologic Emergencies Part I: A Consensus Summary and Research Agenda on Cerebrovascular Disease

Postpartum Migraines: A Long-term Prospective Study

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