Headache and anxiety–depressive disorder comorbidity: the HADAS study

Beghi, Ettore; Allais, Gianni; Cortelli, Pietro; D’Amico, Domenico; Simone, Roberto De; d’Onofrio, Florindo; Genco, S; Manzoni, Gian Camillo; Moschiano, F.; Tonini, Maria Clara; Torelli, Paola; Quartaroli, M.; Roncolato, Maurizio; Salvi, Sara; Bussone, G.

doi:10.1007/s10072-007-0780-6

Cited by 42 publications

(40 citation statements)

References 16 publications

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“…In the current study, we also found that both anxiety and depression levels were higher in CTTH and MOH, which is consistent with previous reports [24][25][26][27][28]. Moreover, age correlates with the line bisection errors found in the current study were consistent with many previous reports [17], implying an age-related and right-(facial decision task) hemispheric dominant tasks [41].…”

Section: Discussionsupporting

confidence: 93%

“…In order to exclude the effect of chronic head pain, we have included a group of patients with CTTH. Bearing in mind that patients with generalized anxiety disorder bisected lines significantly leftward [23], and that both anxiety and depression are comorbid with MOH [24,25] and CTTH [26][27][28], we have used the Zung Self-Rating Anxiety Scale [29] and the Zung Self-Rating Depression Scale [30] to measure the anxiety and depression levels in our participants. the Zung 20-item Self-rating Anxiety Scale [29].…”

Section: Introductionmentioning

confidence: 99%

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Line bisection in medication-overuse and chronic tension-type headaches

Zhang

Gao

Fan

et al. 2014

Translational Neuroscience

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Background: Both medication-overuse headache (MOH) and drug dependence share similar clinical features and the latter displays some deficits in visuospatial attention. The line bisection performance might help to indicate whether there is also a disruption in the visuospatial attention in MOH. Methods: We administered the line bisection test and measured anxiety and depression levels in 21 patients with MOH, 26 patients with chronic tension-type headaches (CTTH) and in 22 healthy volunteers. Results: On average, MOH patients significantly bisected leftward when referring to both frequency and magnitude, whereas the healthy volunteers and CTTH patients bisected slightly rightward. The levels of anxiety and depression were elevated in both MOH and CTTH patients compared to healthy volunteers, but the anxiety / depression levels were not correlated with the line bisection errors in all participants. Conclusions: We found a pronounced pseudoneglect in MOH, which might indicate a relatively hyperactive right or hypoactive left hemisphere, or both, suggesting the disorder's neuropsychological mechanism might overlap with that of drug dependence.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Line bisection in medication-overuse and chronic tension-type headaches

Zhang

Gao

Fan

et al. 2014

Translational Neuroscience

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“…3 Kondisi medis yang telah lama dikaitkan dengan gangguan depresi antara lain nyeri kepala primer tipe tegang atau tension-type headache (TTH). 4 Nyeri kepala tipe ini merupakan nyeri kepala yang paling umum dialami oleh 30-78% masyarakat dan sampai saat ini patogenesisnya masih belum jelas dan bersifat multifaktorial. [5][6][7] Gangguan depresi dapat terjadi bersama-sama dengan TTH sebagai komorbiditas dan berhubungan dengan awitan, perburukan, dan perjalanan nyeri kepala menjadi kronik, baik melalui proses biologik maupun psikologik.…”

Section: 2unclassified

“…8 Hasil wawancara dengan mempergunakan Mini International Neuropsychiatry Interview (MINI), sebanyak 68,3% penderita TTH akan mengalami episode depresif. 4 Penderita TTH kronik akan mengalami depresi yang lebih berat dibandingkan dengan TTH episodik dan nyeri kepala kronik berhubungan dengan skor psikopatologi secara bermakna, tetapi arah hubungannya belum jelas. 9 Komorbiditas gangguan depresi ini berhubungan dengan intensitas nyeri kepala yang lebih berat dan menetap, penurunan kualitas hidup, prognosis yang lebih buruk, menjadi menahunnya penyakit, ketidakpatuhan pengobatan, respons pengobatan yang lebih buruk, serta biaya pengobatan yang membesar.…”

Section: 2unclassified

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Hubungan antara Gejala Gangguan Depresi dan Tension-Type Headache (TTH): Studi Eksploratif

Setiawan¹,

Sadeli²,

Sapiie³

2013

mkb

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AbstrakPrevalensi gangguan depresi semakin meningkat, termasuk yang berkomorbiditas dengan penyakit fisik. Kondisi medik yang telah lama dikaitkan dengan gangguan depresi adalah tension-type headache (TTH). Komorbiditas ini berhubungan dengan perjalanan penyakit TTH kronik. Tujuan penelitian ini untuk mengetahui gejala gangguan depresi yang paling banyak terjadi pada penderita TTH serta menganalisis hubungan antara gejala tersebut dan tipe TTH yang dialaminya. Penelitian ini merupakan studi potong lintang terhadap 32 penderita TTH yang berobat jalan ke Instalasi Rawat Jalan Departemen Ilmu Penyakit Saraf Rumah Sakit Dr. Hasan Sadikin Bandung selama bulan November hingga Desember 2011 yang didiagnosis gangguan depresi. Subjek diperiksa dengan menggunakan instrumen Hamilton Depression Rating Scale (HDRS). Analisis korelasi dilakukan antara skor gejala gangguan depresi yang paling banyak terjadi dengan tipe TTH, dilanjutkan dengan analisis multivariabel untuk mencari rasio prevalens gejala gangguan depresi yang berkorelasi dengan tipe TTH. Angka kejadian gangguan depresi pada TTH didapatkan pada 32/38 penderita, sedangkan gejala gangguan depresi yang paling banyak ditemukan adalah suasana perasaan depresif, kelelahan/berkurangnya minat, dan ansietas psikis. Suasana perasaan depresif dan kelelahan/berkurangnya minat berkorelasi positif dengan tipe TTH (r s =0,411; p=0,019 dan r s =0,379; p=0,032). Dari analisis regresi logistik, hanya suasana perasaan depresif yang meningkatkan risiko TTH kronik, yaitu sebesar 4,74 kali (IK 95% 1,24-18,02). Simpulan, suasana perasaan depresif merupakan gejala yang paling banyak terjadi dan dapat digunakan untuk penapisan dini gangguan depresi pada penderita TTH serta meningkatkan risiko TTH kronik. [MKB. 2013;45 (1) Relationship between Depressive Disorder Symptoms and the Tension-Type Headache (TTH): An Explorative Study AbstractThe prevalence rate of depressive disorders is increasing, including those having comorbidity with physical illnesses. One of the medical conditions that has been related to depressive disorder is tension-type headache (TTH). This comorbidity is related to the chronic course of TTH. This research aims to know which kind of depressive symptoms are most frequently found in TTH patients and to analyze the correlation between those symptoms and the type of TTH. This was a cross sectional study on 32 TTH patients who visited the outpatient clinic of the Neurology Department of Dr. Hasan Sadikin Hospital Bandung during the period of November to December 2011 and who were diagnosed as having depressive disorder. They were examined using Hamilton Depression Rating Scale (HDRS). We correlated the scores of depressive disorder symptoms with the type of TTH, followed by mutivariable analysis to find the prevalence ratio of depressive disorder symptoms which correlated with the type of TTH. The results showed the prevalence rate of depressive disorder in TTH was 32/38 patients while the most frequent depressive disorder symptoms of the subjects were depressive mood, f...

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Neurometabolic correlates of depression and disability in episodic cluster headache

et al. 2010

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A close association between pain, depression and disability has been shown. However, the neurometabolic correlates of this association have been barely investigated in disease states. Episodic cluster headache is a severe headache syndrome and represents a suitable disease model for the investigation of episodic pain. The aim of this study was to explore the relationship between depression and disability as well as pain scores and brain metabolism in patients with cluster headache during the disease period with repetitive pain attacks, but outside an acute attack. Thirteen patients with cluster headache underwent 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission (FDG-PET) and completed questionnaires on depression and disability as well as a pain visual analogue rating scale (VAS). A positive correlation between the depression scores and glucose metabolism was observed in the insular cortex. A positive correlation between the pain disability scores and brain metabolism was detected in the amygdala. The same applied to the pain visual analogue rating scores. Our data underline the association between severe episodic pain, depression and disability. In addition to this clinical observation, our results stress the importance of the insula and amygdala in pain processing and suffering.

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Headache and anxiety–depressive disorder comorbidity: the HADAS study

Cited by 42 publications

References 16 publications

Line bisection in medication-overuse and chronic tension-type headaches

Line bisection in medication-overuse and chronic tension-type headaches

Hubungan antara Gejala Gangguan Depresi dan Tension-Type Headache (TTH): Studi Eksploratif

Neurometabolic correlates of depression and disability in episodic cluster headache

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