Head trauma results in manyfold increased risk of multiple sclerosis in genetically susceptible individuals
Eva Johansson,
Lars Alfredsson,
Pernilla Strid
et al.
Abstract:BackgroundLarge register-based studies have reported an association between head trauma and increased risk of multiple sclerosis (MS). We aimed to investigate possible interactions between head trauma and MS-associated HLA genes in relation to MS risk.MethodsWe used a Swedish population-based case-control study (2807 incident cases, 5950 matched controls with HLA genotypes available for 2057 cases, 2887 controls). Subjects with and without a history of self-reported head trauma were compared regarding MS risk,… Show more
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