2012
DOI: 10.1177/1098612x12463162
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Head trauma as a possible cause of central diabetes insipidus in a cat

Abstract: A 13-month-old female domestic shorthair cat presented with a 10-month history of polyuria and polydipsia that began after having been hit by a car. Neurological examination revealed visual deficits and an absent bilateral menace response. Hematological and serum biochemical analyses were within reference values, but hyposthenuria was identified. Failure to concentrate urine during the water deprivation test followed by an increase in urine specific gravity after administration of synthetic antidiuretic hormon… Show more

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Cited by 5 publications
(5 citation statements)
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References 26 publications
(53 reference statements)
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“…Several extrarenal actions of DDAVP have also been described: release of two coagulation factors (Factor VIIIc and von Willebrand factor (Richardson and Robinson, 1985); a decrease in blood pressure and peripheral resistance; and an increase in plasma renin activity (Schwartz et al, 1985). Additionally, blood chemistry studies and necropsies on treated dogs (Ferring, 1985) and clinical experience in dogs and cats with CDI (Kraus, 1987;Harb et al, 1996;Oliveira et al, 2013) indicate that the drug is safe for use in dogs and cats. Similar findings are noted in experiments with normal dogs (Ferring, 1985) and in spontaneous canine cases of CDI.…”
Section: Vasopressin Analogues (Used In Central Diabetes Insipidus Anmentioning
confidence: 99%
“…Several extrarenal actions of DDAVP have also been described: release of two coagulation factors (Factor VIIIc and von Willebrand factor (Richardson and Robinson, 1985); a decrease in blood pressure and peripheral resistance; and an increase in plasma renin activity (Schwartz et al, 1985). Additionally, blood chemistry studies and necropsies on treated dogs (Ferring, 1985) and clinical experience in dogs and cats with CDI (Kraus, 1987;Harb et al, 1996;Oliveira et al, 2013) indicate that the drug is safe for use in dogs and cats. Similar findings are noted in experiments with normal dogs (Ferring, 1985) and in spontaneous canine cases of CDI.…”
Section: Vasopressin Analogues (Used In Central Diabetes Insipidus Anmentioning
confidence: 99%
“… 2 , 3 , 11 Post-traumatic, iatrogenic (surgery) and idiopathic CDI have been reported in cats of all ages. 1 , 5 , 6 , 8 In these cases, the main clinical signs were PU/PD. Physical examination is often unremarkable on admission, but clinical signs indicating the cause (amaurosis, circling) or intracellular dehydration (decreased consciousness, coma) may be present.…”
Section: Discussionmentioning
confidence: 90%
“…Thus far, there have been 12 single case reports and one case series involving five cats. 1 – 13 CDI is the result of a complete or partial lack of AVP secretion by the hypophysis. No gender or breed predispositions have been reported.…”
Section: Discussionmentioning
confidence: 99%
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“…4 This can be a result of a deficiency in the synthesis, 9,10 transport, or release of the hormone. 10,11 CDI in cats has been reported to occur as a result of congenital pituitary malformation, 12 head trauma and neoplasia; 9,11,1316 ; however, most cases are idiopathic. 2,14 In complete CDI there is a total absence of AVP, while in partial CDI some AVP is present.…”
Section: Discussionmentioning
confidence: 99%