Head trauma as a possible cause of central diabetes insipidus in a cat

Oliveira, Karen Maciel de; Fukushima, Fabíola Bono; Oliveira, Camila Maciel de; Rosado, Isabel Rodrigues; Torres, Bruno Benetti Junta; Lavor, Mário Sérgio Lima de; Silva, Carla Maria O; Melo, Eliane Gonçalves de

doi:10.1177/1098612x12463162

Cited by 5 publications

(5 citation statements)

References 26 publications

(53 reference statements)

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“…Several extrarenal actions of DDAVP have also been described: release of two coagulation factors (Factor VIIIc and von Willebrand factor (Richardson and Robinson, 1985); a decrease in blood pressure and peripheral resistance; and an increase in plasma renin activity (Schwartz et al, 1985). Additionally, blood chemistry studies and necropsies on treated dogs (Ferring, 1985) and clinical experience in dogs and cats with CDI (Kraus, 1987;Harb et al, 1996;Oliveira et al, 2013) indicate that the drug is safe for use in dogs and cats. Similar findings are noted in experiments with normal dogs (Ferring, 1985) and in spontaneous canine cases of CDI.…”

Section: Vasopressin Analogues (Used In Central Diabetes Insipidus Anmentioning

confidence: 99%

Water Metabolism and Diabetes Insipidus

Nelson¹

2015

Canine and Feline Endocrinology

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Section: Vasopressin Analogues (Used In Central Diabetes Insipidus Anmentioning

confidence: 99%

Water Metabolism and Diabetes Insipidus

Nelson¹

2015

Canine and Feline Endocrinology

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“… 2 , 3 , 11 Post-traumatic, iatrogenic (surgery) and idiopathic CDI have been reported in cats of all ages. 1 , 5 , 6 , 8 In these cases, the main clinical signs were PU/PD. Physical examination is often unremarkable on admission, but clinical signs indicating the cause (amaurosis, circling) or intracellular dehydration (decreased consciousness, coma) may be present.…”

Section: Discussionmentioning

confidence: 90%

“…Thus far, there have been 12 single case reports and one case series involving five cats. 1 – 13 CDI is the result of a complete or partial lack of AVP secretion by the hypophysis. No gender or breed predispositions have been reported.…”

Section: Discussionmentioning

confidence: 99%

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A case of central diabetes insipidus associated with a congenital cyst of the sella turcica in a young cat

Duperrier

Fusellier

Lenaerts

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 1-year-old neutered male domestic shorthair cat was presented for polyuria and polydipsia which had progressed since adoption, 7 months previously. On admission, clinical examination did not reveal any remarkable features. Urinalysis showed marked hyposthenuria and calculated plasma osmolality was high, suggesting diabetes insipidus. A positive response to desmopressin administration appeared to confirm pituitary dysfunction. Brain MRI revealed a lesion compatible with a cyst or a neoplasm compressing the pituitary gland. A follow-up MRI performed 9 months later showed that the lesion was stable, which at first argued in favour of a congenital pituitary cyst. Intranasal administration of desmopressin was then used to achieve a long-term clinical response. Relevance and novel information Central diabetes insipidus (CDI) is a rare cause of polyuria and polydipsia in cats, resulting from inadequate or impaired secretion of antidiuretic hormone from the posterior pituitary gland. Recognised causes include head trauma, central nervous system (CNS) neoplasia, idiopathic CDI and congenital pituitary cysts. Apart from one cat with CNS lymphoma, the few previously reported feline cases have described CDI in young cats with a previous history of trauma, but brain imaging has rarely been performed to look for underlying anatomical abnormalities. This report describes the first case of CDI in a cat with a confirmed congenital pituitary cyst and, as in previous cases, demonstrates successful treatment with desmopressin.

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“…4 This can be a result of a deficiency in the synthesis, 9,10 transport, or release of the hormone. 10,11 CDI in cats has been reported to occur as a result of congenital pituitary malformation, 12 head trauma and neoplasia; 9,11,13–16 ; however, most cases are idiopathic. 2,14 In complete CDI there is a total absence of AVP, while in partial CDI some AVP is present.…”

Section: Discussionmentioning

confidence: 99%

Probable primary polydipsia in a domestic shorthair cat

Long

Williams

Savage

et al. 2015

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 10-month-old neutered male domestic shorthair cat presented with a 4 month history of polyuria and polydipsia. After a thorough diagnostic work-up the only abnormal findings were hyposthenuria and an elevated random plasma osmolality level. Trial therapy with the oral and ophthalmic forms of desmopressin failed to concentrate urine. A modified water deprivation test confirmed the ability to concentrate urine above a urine specific gravity (USG) of 1.035. After transitioning the cat to a higher sodium diet and instituting several enrichment changes to the cat’s environment, average water consumption and urine output levels decreased to almost normal levels and USG increased from 1.006 to 1.022. These findings provide strong evidence that primary polydipsia was the underlying etiology of the cat’s condition.Relevance and novel informationThis case report exemplifies the challenges faced when a cat presents for polyuria and polydipsia without an obvious cause identified on routine diagnostics. To our knowledge, this is the first report of primary polydipsia in a cat.

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Head trauma as a possible cause of central diabetes insipidus in a cat

Cited by 5 publications

References 26 publications

Water Metabolism and Diabetes Insipidus

Water Metabolism and Diabetes Insipidus

A case of central diabetes insipidus associated with a congenital cyst of the sella turcica in a young cat

Probable primary polydipsia in a domestic shorthair cat

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