Head-to-head comparisons of [68Ga]Ga-PSMA-11 PET/CT, multiparametric MRI, and prostate-specific antigen for the evaluation of therapeutic responses to neoadjuvant chemohormonal therapy in high-risk non-metastatic prostate cancer patients: a prospective study

Ke, Zhi‐Bin; Chen, Shaoming; Chen, Jia-Yin; Chen, Shao‐Hao; You, Qi; Sun, Jiang-Bo; Xue, Yu-Ting; Sun, Xiong‐Lin; Wu, Xiaohui; Zheng, Qing‐Shui; Wei, Yong; Xue, Xue-Yi; Xu, Ning

doi:10.1007/s00259-022-06047-6

Cited by 3 publications

(1 citation statement)

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“…Of these patients, 5 patients (6.94%) had pCR and 19 patients (26.39%) had MRD after NCHT. Furthermore, multivariate logistic analysis revealed that the post-NCHT maximum standardized uptake value (SUVmax) of the primary lesions on 68 Ga-PSMA PET/CT was an independent predictor of a favorable pathologic response to NCHT (OR=0.209, 95% CI: 0.102-0.429, P<0.001) [25].…”

Section: Role Of Psma Pet/ct In Nchtmentioning

confidence: 99%

Neoadjuvant chemohormonal therapy before radical prostatectomy in high-risk prostate cancer: a mini-review

Fan

2024

Am J Clin Exp Urol

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High-risk localized prostate cancer (PCa) has the potential of recurrence and progression to a lethal phenotype, and neoadjuvant therapy followed by radical prostatectomy (RP) may be an option for these patients. Docetaxel has been recently shown to be an effective chemotherapeutic agent for high-volume metastatic hormonesensitive PCa and metastatic castration-resistant PCa, and these increased efficacy create the impetus to assess the potential role of preoperative docetaxel in high-risk localized PCa. In this mini-review, we found that neoadjuvant chemohormonal therapy (NCHT) may be an effective neoadjuvant regimen to improve oncological outcome of high-risk PCa. However, the addition of docetaxel in the neoadjuvant setting would unavoidably increase the rate of adverse events, impose additional economic burdens. Therefore, suitable patient selection is crucial and pathological response might be a surrogate endpoint. Furthermore, we also found that molecular imaging prostate-specific membrane antigen (PSMA) PET/CT was a promising tool to evaluation the effectiveness of NCHT, and the expression status of AR, AR-V7, Ki-67, PTEN and TP53 might be helpful for urologists to identify more suitable candidates for NCHT.

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Section: Role Of Psma Pet/ct In Nchtmentioning

confidence: 99%