Head-to-head comparison of uncorrected and scatter corrected, summed and end diastolic myocardial perfusion SPECT in coronary artery disease

Hambye, Anne-Sophie; Vervaet, A.; Dobbeleir, André

doi:10.1097/00006231-200404000-00006

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Photon scatter also affects image quality in both small and larger hearts resulting in blurring of the myocardial borders. Observations by Hambye et al indicate that the presence of scattered photons in the main photo peak is of greater importance in smaller hearts then in large hearts [24]. So scatter compensation techniques such as methods base on the energy window, deconvolution or reconstruction are especially useful for improving image quality in smaller hearts [25].…”

Section: Discussionmentioning

confidence: 99%

The consequences of a new software package for the quantification of gated-SPECT myocardial perfusion studies

Veen

Scholte

Dibbets‐Schneider

et al. 2010

Eur J Nucl Med Mol Imaging

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PurposeSemiquantitative analysis of myocardial perfusion scintigraphy (MPS) has reduced inter- and intraobserver variability, and enables researchers to compare parameters in the same patient over time, or between groups of patients. There are several software packages available that are designed to process MPS data and quantify parameters. In this study the performances of two systems, quantitative gated SPECT (QGS) and 4D-MSPECT, in the processing of clinical patient data and phantom data were compared.MethodsThe clinical MPS data of 148 consecutive patients were analysed using QGS and 4D-MSPECT to determine the end-diastolic volume, end-systolic volume and left ventricular ejection fraction. Patients were divided into groups based on gender, body mass index, heart size, stressor type and defect type. The AGATE dynamic heart phantom was used to provide reference values for the left ventricular ejection fraction.ResultsAlthough the correlations were excellent (correlation coefficients 0.886 to 0.980) for all parameters, significant differences (p < 0.001) were found between the systems. Bland-Altman plots indicated that 4D-MSPECT provided overall higher values of all parameters than QGS. These differences between the systems were not significant in patients with a small heart (end-diastolic volume <70 ml). Other clinical factors had no direct influence on the relationship. Additionally, the phantom data indicated good linear responses of both systems.ConclusionThe discrepancies between these software packages were clinically relevant, and influenced by heart size. The possibility of such discrepancies should be taken into account when a new quantitative software system is introduced, or when multiple software systems are used in the same institution.

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Section: Discussionmentioning

confidence: 99%

The consequences of a new software package for the quantification of gated-SPECT myocardial perfusion studies

Veen

Scholte

Dibbets‐Schneider

et al. 2010

Eur J Nucl Med Mol Imaging

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“…Photon scatter correction and compensation techniques based on energy windowing have been shown to improve image quality and volume measurements (26,27). In particular, scattered photons in the main photopeak have a greater impact in smaller hearts than in larger hearts (28). Although CZT cameras offer a high energy resolution (15), the scatter fraction remains similar to that observed with conventional Anger cameras (18).…”

Section: Global LV Functionmentioning

confidence: 99%

Left Ventricular Function Assessment Using 2 Different Cadmium-Zinc-Telluride Cameras Compared with a γ-Camera with Cardiofocal Collimators: Dynamic Cardiac Phantom Study and Clinical Validation

et al. 2016

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This study compared two SPECT cameras with cadmium-zinc-telluride (CZT) detectors to a conventional Anger camera with cardiofocal collimators for the assessment of left ventricular (LV) function in a phantom and patients. Methods: A gated dynamic cardiac phantom was used. Eighteen acquisitions were processed on each CZT camera and the conventional camera. The total number of counts within a myocardial volume of interest varied from 0.25 kcts to 1.5 Mcts. Ejection fraction was set to 33%, 45%, or 60%. Volume, LV ejection fraction (LVEF), regional wall thickening, and motion (17-segment model) were assessed. One hundred twenty patients with a low pretest likelihood of coronary artery disease and normal findings on stress perfusion SPECT were retrospectively analyzed to provide the reference limits for end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction, and regional function for each camera model. Results: In the phantom study, for each ejection fraction value, volume was higher for the CZT cameras than for the conventional camera, resulting in a decreased but more accurate LVEF (all P , 0.001). In clinical data, body-surface-indexed EDV and ESV (mL/m 2 ) were higher for one of the CZT cameras (Discovery NM 530c) than for the other (D-SPECT) or the conventional camera (respectively, 40.5 ± 9.2, 37 ± 7.9, and 35.8 ± 6.8 for EDV [P , 0.001] and 12.5 ± 5.3, 9.4 ± 4.2, and 8.3 ± 4.4 for ESV [P , 0.001]), resulting in a significantly decreased LVEF: 70.3% ± 9.1% vs. 75.2% ± 8.1% vs. 77.8% ± 9.3%, respectively (P , 0.001). Conclusion: The new CZT cameras yielded global LV function results different from those yielded by the conventional camera. LV volume was higher for the Discovery NM 530c than for the D-SPECT or the conventional camera, leading to decreased LVEF in healthy subjects. These differences should be considered in clinical practice and warrant the collection of a specific reference database.

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DePuey

2022

Journal of Nuclear Cardiology

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Head-to-head comparison of uncorrected and scatter corrected, summed and end diastolic myocardial perfusion SPECT in coronary artery disease

Cited by 3 publications

References 14 publications

The consequences of a new software package for the quantification of gated-SPECT myocardial perfusion studies

The consequences of a new software package for the quantification of gated-SPECT myocardial perfusion studies

Left Ventricular Function Assessment Using 2 Different Cadmium-Zinc-Telluride Cameras Compared with a γ-Camera with Cardiofocal Collimators: Dynamic Cardiac Phantom Study and Clinical Validation

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