Head Injury as Risk Factor for Psychiatric Disorders: A Nationwide Register-Based Follow-Up Study of 113,906 Persons With Head Injury

Orlovska, Sonja; Pedersen, Michael; Benros, Michael E.; Mortensen, Preben Bo; Agerbo, Esben; Nordentoft, Merete

doi:10.1176/appi.ajp.2013.13020190

Cited by 139 publications

(100 citation statements)

References 43 publications

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“…The risk of depression associated with TBI in our sample was similar in size to that described for younger adults in Denmark (Orlovska et al, 2014) and for World War II American veterans (Holsinger et al, 2002). This increase in risk, if causal, would account for about 7% of the cases of depression in later life (we acknowledge that the statistical methods used most likely inflate the true proportion of depression and cognitive impairment attributable to TBI).…”

Section: Interpretation Of the Resultssupporting

confidence: 69%

“…We also acknowledge that this study was limited to men. Current epidemiological evidence indicates that the psychiatric complications of TBI are largely independent of gender (Orlovska et al, 2014), thereby suggesting that similar findings might be expected for women. The link between depression (past or current) and TBI measured by self-report or data linkage was associated with similar effect sizes, although the association with current depression was more pronounced for self-reported than WADLS-recorded TBI.…”

Section: Strengths and Limitationsmentioning

confidence: 74%

See 1 more Smart Citation

Prevalence, associated factors, mood and cognitive outcomes of traumatic brain injury in later life: the health in men study (HIMS)

Almeida

Hankey

Yeap

et al. 2015

Int J Geriatr Psychiatry

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Section: Interpretation Of the Resultssupporting

confidence: 69%

Section: Strengths and Limitationsmentioning

confidence: 74%

Prevalence, associated factors, mood and cognitive outcomes of traumatic brain injury in later life: the health in men study (HIMS)

Almeida

Hankey

Yeap

et al. 2015

Int J Geriatr Psychiatry

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“… Spinal concussion [20]: posttraumatic symptoms arising from the cervical spinal cord such as tingling, numbness, weakness.  Psychological Concussion [21]: posttraumatic symptoms arising from the influence of mechanical energy on one's overall psychological state. This is a more abstract "injury", the magnitude and expression (symptoms) of which depend on not only the magnitude of the mechanical input but also on the pre-existing personality "strength".…”

Section: Irc-15-02 Ircobi Conference 2015mentioning

confidence: 99%

Pediatric concussion: biomechanical differences between outcomes of transient and persistent (> 4 weeks) postconcussion symptoms

Post

Hoshizaki

Zemek

et al. 2017

PED

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OBJECTIVECurrently, little is known about the biomechanics of head impact for concussion in youths (ages 5 to 18 years). Even less is known about the biomechanical characteristics and variables related to head impacts that may be useful in differentiating between transient and persistent postconcussion symptoms in a youth population. The purpose of this research was to examine the differences in biomechanics of youth head impact for transient postconcussion symptoms (TPCSs) and persistent postconcussion symptoms (PPCSs) by using data from a hospital population.METHODSIn a laboratory setting and using physical, computational, and finite element models, the authors reconstructed falling events in a large cohort of patients who had sustained a brain injury that resulted in transient or persistent postconcussion symptoms. The falling events and resulting concussions for the TPCS and PPCS patient groups were analyzed in terms of force, energy, peak resultant linear and rotational accelerations, and maximum principal strain in the gray and white matter of the brain, as well as measurements of cumulative strain damage.RESULTSThe results indicated that there were no significant differences between the groups for any of the variables analyzed.CONCLUSIONSWith methods derived for use in an adult population, the magnitudes of peak linear acceleration for the youth data set were determined to be above the 50% risk of injury. The youth data set showed higher brain tissue strain responses for lower energy and impact velocities than measured in adults, suggesting that youths are at higher risk of concussive injury at lower event severities. A trend shown by some variables indicated that larger magnitudes of response were associated with PPCSs, but no single measurement variable consistently differentiated between the TPCS and PPCS groups. It is possible that using the biomechanics of head and brain responses to predict a subjective symptom load may not be appropriate. To enhance future biomechanical analyses, further investigations should include the use of quantifiable measures of brain injury linked to clinical outcomes and possible confounding factors such as history of brain injury and patient predisposition.

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“…The neurodevelopmental hypothesis of SZ suggest that infection, obstetric complications, craniocerebral injury, or specific environmental influences during pregnancy or during the postpartum period might induce nerve degeneration and neuronal apoptosis in the central nervous system (CNS), which might result in abnormal neurological development and contribute to the development of SZ [2][3][4][5]. On the other hand, the GABAergic inhibitory interneurons are indispensable for normal function in the CNS [6], and the dysfunction of the GABAergic system has been implicated in several cognitive impairments in SZ [1,7].…”

Section: Introductionmentioning

confidence: 99%

Sub-chronic Antipsychotic Drug Administration Reverses the Expression of Neuregulin 1 and ErbB4 in a Cultured MK801-Induced Mouse Primary Hippocampal Neuron or a Neurodevelopmental Schizophrenia Model

Tang

Yang

et al. 2016

Neurochem Res

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It has been reported that specific environmental influences during the postpartum period might contribute to the development of schizophrenia (SZ). Administration of MK801 during early development led to persistent brain pathology. Glutamate decarboxylase 1 (GAD67) and parvalbumin (PV), and neuregulin 1 (NRG1)/ErbB4 signaling were closely associated with SZ pathology. We postulated therefore that NMDA receptor antagonists exposure during the postpartum period may be associated with expression dysregulation of some of the SZ candidate proteins. To test this, we used mouse primary hippocampal neurons and neonatal male mice treated with the NMDA receptor antagonist, MK801 at postnatal day 4 (P4) or P7, followed by the treatments of antipsychotic drugs (i.e., olanzapine, risperidone, and haloperidol). The expressions of GAD67, PV, NRG1, and ErbB4 in in vitro and in vivo SZ models were detected with Western blot analysis and immunohistochemistry, respectively. Behavioral tests (locomotion activity, social interaction, novel object recognition and prepulse inhibition) were measured. We found MK801 decreased the expression of GAD67, PV, NRG1 and ErbB4, and induced obvious behavioral alterations, while antipsychotics reversed these alterations. These results suggest that exposure to the NMDA receptor antagonist in early development may lead to long-lasting influence on the expression of specific proteins, such as GAD67, PV, NRG1, and ErbB4. Moreover, our results suggest that rescue of the activation of the NRG1/ErbB4 signaling pathway may be one of the mechanisms by which antipsychotic drugs have an antipsychotic effect.

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Head Injury as Risk Factor for Psychiatric Disorders: A Nationwide Register-Based Follow-Up Study of 113,906 Persons With Head Injury

Cited by 139 publications

References 43 publications

Prevalence, associated factors, mood and cognitive outcomes of traumatic brain injury in later life: the health in men study (HIMS)

Prevalence, associated factors, mood and cognitive outcomes of traumatic brain injury in later life: the health in men study (HIMS)

Pediatric concussion: biomechanical differences between outcomes of transient and persistent (> 4 weeks) postconcussion symptoms

Sub-chronic Antipsychotic Drug Administration Reverses the Expression of Neuregulin 1 and ErbB4 in a Cultured MK801-Induced Mouse Primary Hippocampal Neuron or a Neurodevelopmental Schizophrenia Model

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