Head fat is a novel method of measuring metabolic disorder in Chinese obese patients

Abstract

BackgroundBody adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. The aim of this study was to investigate the association between head fat and metabolic values in Chinese obese patients.MethodsData of this cross-sectional study from 66 obese patients were collected. Fat distribution was measured by dual-energy X-ray absorptiometry, and data of body weight, body mass index (BMI), neck circumference (NC), waist circumference (WC), hip circumference (HC), visceral index, basal metabolism (BM), glucose metabolism, lipid levels, uric acid (UA) had been collected.Results1) Head fat was significantly associated with BMI, WC, HC, visceral index, BM, total fat and total fat excluding head fat in both males and females (p < 0.05). Head fat was positively correlated with upper limb fat, trunk fat, weight, fasting plasma C peptide, fasting plasma insulin and UA in women(p < 0.05), and the association was not statistically significant in male (p > 0.05). Head fat was positively corrected with NC in males (p < 0.05) but not females (p > 0.05). There was no significant correlation between head fat and fasting plasma glucose, total choleslerolemia, triglyceridemia, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and free fat acid in either gender (p > 0.05). 2) Receiver operating characteristic analysis showed that a head fat of 1925.6 g and a head fat of 1567.85 g were the best cut-off values to determine subjects with low high-density lipoprotein cholesterol and hyperuricemia respectively.ConclusionsHead fat accumulation was closely associated with increased body fat, hyperinsulinemia, hyperuricemia, and impared lipid profile, suggesting it might be used as an indicator for dyslipidemia and hyperuricemia.

Neck circumference as a risk factor of screen-detected diabetes mellitus: community-based study

“…Studies, that assessed the significance of neck circumference in the context of cardiometabolic risk indicate that NC is associated with CVD risk factors even after adjustment for multidetector computed tomography assessed visceral adipose tissue [ 7 ] and measured by dual-energy X-ray absorptiometry head fat was positively corrected with NC in males but not females. There was no significant correlation between head fat and fasting plasma glucose [ 26 ].…”

FGF21 Is Associated with Acanthosis Nigricans in Obese Patients

“…Obesity is a public health problem that has raised concern worldwide [ 13 ]. Acanthosis nigricans is the most common dermatologic manifestation of obesity.…”

DEXA Scan Body Fat Mass Distribution in Obese and Non-Obese Individuals and Risk of NAFLD—Analysis of 10,865 Individuals

“…This aligns with previous studies where the only DXA measure that improved the prediction of insulin sensitivity was percent head fat, and only in females [ 29 ]. Additionally, head fat has been positively correlated with upper limb fat, trunk fat, fasting plasma insulin, and uric acid in females [ 30 ]. Despite its significant association with different anthropological and metabolic variables in women, the current implications of head fat remain to be ascertained and may provide an interesting angle to understanding disease in NAFLD.…”