Head and Neck Rhabdomyosarcoma: Clinical and Pathologic Characterization of Seven Cases

Chen, Eleanor; Ricciotti, Robert W.; Futran, Neal D.; Oda, Dolphine

doi:10.1007/s12105-016-0771-0

Cited by 33 publications

(41 citation statements)

References 26 publications

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“…Prior studies investigating rhabdomyosarcoma demographics and prognostic factors using databases have largely focused on specific anatomic sites or JOURNAL OF ORTHOPAEDIC RESEARCH ® OCTOBER 2019 subtypes. 3,4,6,[14][15][16][17][18][19][20] In a 2017 study by Nasioudis et al 15 rhadomyosarcoma of the lower female genital tract was shown to be most prevalent in prepubertal girls and adolescents, but carry excellent survival rates. Additionally, rare cases affecting adults resulted in poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The incidence is greatest in young adults under the age of 20, with an incidence rate of 4.4 cases per one million. 3 Incidence decreases with age, representing only 1% of adult solid tumor malignancies. [4][5][6] Most cases occur sporadically, although genetic conditions such as Li-Fraumani syndrome and Neurofibromatosis type 1 are associated with increased risk.…”

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confidence: 99%

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Epidemiology, Incidence, and Survival of Rhabdomyosarcoma Subtypes: SEER and ICES Database Analysis

Amer

Thomson²,

Congiusta

et al. 2019

Journal Orthopaedic Research

102

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Rhabdomyosarcoma is the most common soft‐tissue sarcoma in children and adolescents and accounts for 3% of all pediatric tumors. Subtypes include alveolar, spindle cell, embryonal, mixed‐type, pleomorphic, and rhabdomyosarcoma with ganglionic differentiation. The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was queried for patients diagnosed with any type of rhabdomyosarcoma between 1973 and 2014. Patient demographics, tumor characteristics, and incidence were studied with χ2 analysis. Survival was modeled with Kaplan–Meier survival curves and Cox proportional hazards models were used to assess the effect of age and gender on survival. Pleomorphic subtype had higher grade and larger sized tumors compared to other subtypes (p < 0.05). Pleomorphic and alveolar rhabdomyosarcoma had the worst overall survival with a 26.6% and 28.9% 5‐year survival, respectively. Embryonal rhabdomyosarcoma had the highest 5‐year survival rate (73.9%). Tumor size was negatively correlated with survival months, indicating patients with larger tumors had shorter survival times (p < 0.05). Presence of higher‐grade tumors and metastatic disease at presentation were negatively correlated with survival months (p < 0.05). No significant differences in the survival were found between gender or race between all of the subtypes (p > 0.05). This study highlights key differences in the demographic and survival rates of the different types of rhabdomyosarcoma that can be used for more tailored patient counseling. We also demonstrate that large, population‐level databases provide sufficient data that can be used in the analysis of rare tumors. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2226–2230, 2019

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Epidemiology, Incidence, and Survival of Rhabdomyosarcoma Subtypes: SEER and ICES Database Analysis

Amer

Thomson²,

Congiusta

et al. 2019

Journal Orthopaedic Research

102

View full text Add to dashboard Cite

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“…Rarely, it is confused with other benign lesions such as myositis ossificans, pyogenic myositis. Beside this non-Hodgkin lymphoma, neuroblastoma, Ewing sarcoma familial tumors, acute myeloid leukemia, Langerhans cell histiocytosis should be considered in the differential diagnosis of rhabdomyosarcoma (2,4,7). The gold standard diagnostic method in soft tissue mass is histopathological examination.…”

Section: Discussionmentioning

confidence: 99%

Primary hand rhabdomyosarcoma: a rare case report

Koç¹,

Ozercan²

2017

J Turgut Ozal Med Cent

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Rhabdomyosarcomas are malignant, soft tissue tumors with striated muscle origin. Malignant round cell tumors are the common malignancy of childhood. The primary localizations are head and neck and genitourinary system. Only 7 % of lesion is seen in the upper extremity. Primer hand involvement is rare. In this article, we presented a 16-year-old girl who admitted to our clinic with a complaint of a painful mass that grew rapidly in the left hand thenar area. Imaging findings revealed a heterogeneous solid mass lesion between the 1st and 2nd fingers, which showed dense contrast enhancement, approximately 6x5x7 cm in size, leading to destruction in the bony structures. A histopathological examination of the mass indicated alveolar rhabdomyosarcoma. We decided to present this rare entity with the radiological imaging findings.

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“…Based on the overall clinical presentation of a painless, rapidly enlarging, recurrent maxillary growth along with the histopathological features, our differential diagnosis included a broad spectrum of neoplasms from small round-cell neoplasms such as RMS, extraosseous ewing sarcoma (ES), lymphoma or olfactory neuroblastoma to spindle cell tumour-like fibrosarcoma or spindle cell carcinoma 6 9…”

Section: Differential Diagnosismentioning

confidence: 99%

“…The commonly affected sites are the head and neck region, genitourinary tract, retroperitoneum, extremities, trunk, chest, perineum and gastrointestinal tract 3 7 8 . The head and neck region is commonly involved in children, whereas in adults, the trunk and extremities are mainly affected 7 9 10. Areas involved in the head and neck region are divided into three main groups, cranial parameningeal, orbital and non-orbital–non-parameningeal which accounts for 35%–40% of all RMS cases, of which 10%–12% cases involve the oral cavity, with an affinity for the palate, tongue, lips and buccal mucosa 1 3 7 8 11–13.…”

Section: Introductionmentioning

confidence: 99%

Rhabdomyosarcoma involving maxilla mimicking gingival enlargement: A diagnostic challenge

Nangalia¹,

Shah²,

Sheikh³

et al. 2019

BMJ Case Rep

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Rhabdomyosarcoma (RMS) is a rare, rapidly growing, highly aggressive malignant neoplasm, originating from undifferentiated mesenchymal cells that retain their ability to differentiate into skeletal muscle. It mainly affects children, accounts for <1% of all adult malignancies and has varied clinical presentations. The head and neck region accounts for 35%–40% of all RMS cases, of which 10%–12% cases involve the oral cavity. This report deals with a case of RMS in a 40-year-old woman, primarily involving maxillary gingiva for which she underwent excision with subsequent recurrences. The uniqueness of this case is that it reminds us of the essential clinical dictum that ‘every growth we encounter, no matter how benign it appears clinically, should be looked upon with suspicion’. Hence, proper integration of history, clinical examination and investigation is required to reach a correct diagnosis enabling early treatment, thereby preventing functional and aesthetic loss and psychological trauma.

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Head and Neck Rhabdomyosarcoma: Clinical and Pathologic Characterization of Seven Cases

Abstract: were observed, suggesting aggressive clinical behavior regardless of subtype.

Cited by 33 publications

References 26 publications

Epidemiology, Incidence, and Survival of Rhabdomyosarcoma Subtypes: SEER and ICES Database Analysis

Epidemiology, Incidence, and Survival of Rhabdomyosarcoma Subtypes: SEER and ICES Database Analysis

Primary hand rhabdomyosarcoma: a rare case report

Rhabdomyosarcoma involving maxilla mimicking gingival enlargement: A diagnostic challenge

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