Head and Neck Paragangliomas: Experience in 126 Patients With 162 Tumours

Álvarez-Morujo, Ricardo José González-Orús; Ruiz, Maximino; Belisario, Julia da Costa; Guirado, Tomás Martinez; Yurrita, Bartolomé Scola

doi:10.1016/j.otoeng.2014.11.004

Cited by 19 publications

(14 citation statements)

References 27 publications

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“…In contrast, some other European studies report higher rates: a Dutch study showed that 80% had a positive family history, and 99.5% of them had a mutation in the SDHx genes [10]. In a Spanish study, 40 patients were subjected to genetic testing, and 50% of them had a mutation [11].…”

Section: Mutations and Genetic Screeningmentioning

confidence: 87%

Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment

Rana

Østhus

Heimdal

et al. 2020

Acta Oto-Laryngologica

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Section: Mutations and Genetic Screeningmentioning

confidence: 87%

Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment

Rana

Østhus

Heimdal

et al. 2020

Acta Oto-Laryngologica

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“…These assumptions change for germinal mutation cases, which typically present at an earlier age and predominantly in males. 8,[12][13][14] Multicentricity rates in the literature range from 7% to 58%, with reports of a higher incidence for familial cases. 12 In our series, 20.5% of patients were seen with multiple paragangliomas and it increased to 29.1% in the subset of patients with germinal mutations.…”

Section: Discussionmentioning

confidence: 99%

“…2 Factors such as multicentricity, endocrine activity, malignancy and genetic predisposition further complicate an ever-changing algorithm, which trends towards individualized management. 2,[12][13][14] The aim of this study was to characterize the presenting symptoms, secretory status, genetics, imaging features, treatment modalities, post-treatment complications and survival of patients with head and neck paragangliomas (HNPs) treated at a single institution.…”

Section: Introductionmentioning

confidence: 99%

Paragangliomas da Cabeça e Pescoço: A Experiência de um Centro Oncológico do Sul da Europa

et al. 2022

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Introduction: Paragangliomas are usually benign slow-growing tumors, but they are locally invasive and can cause significant morbidity. The aim of this study was to characterize the presenting symptoms, secretory status, genetics, imaging features, treatment modalities, post-treatment complications and survival of patients with head and neck paragangliomas treated at a single institution.Material and Methods: We retrospectively reviewed the clinical records of patients managed at our center between 1997 and 2020.Results: Seventy-three patients were included in the study, encompassing 89 head and neck paragangliomas. Forty-eight patients (65.8%) were female and 15 (20.5%) had multiple tumor sites (including 10 patients with multicentric benign paragangliomas and five with disseminated malignant disease). Regarding location, our series encompassed 40 temporal bone paragangliomas (44.9%), 24 carotid body paragangliomas (27%), 22 vagal paragangliomas (24.7%), two laryngeal paragangliomas (2.2%) and one sinonasal paraganglioma (1.1%). Excessive catecholamine secretion was detected in 11 patients (15.1%). Sixty-four patients (87.7%) underwent genetic testing. Of those, 24 (37.5%) exhibited pathogenic succinate dehydrogenase complex germline mutations. Regarding patients who presented with untreated disease, 45 patients (66.2%), encompassing 55 tumors, underwent surgery as primary treatment modality, 20 (29.4%; 23 tumors) were initially treated with radiotherapy and three patients (4.4%, encompassing three solitary tumors) were kept solely under watchful waiting. Five-year overall survival was 94.9% and disease-free survival was 31.9%.Conclusion: Head and neck paragangliomas are rare, slow-growing but locally aggressive tumors resulting in high morbidity but low mortality rates.

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“…Of these, 80% to 90% affect the adrenal gland (pheochromocytomas). Extra‐adrenal PGs are frequently located in the head and neck (70%), of which the majority (70%‐80%) occur in the carotid body, followed by PGs with jugular, tympanic, and vagal locations 1‐3 …”

Section: Introductionmentioning

confidence: 99%

Simple and complex carotid paragangliomas. Three decades of experience and literature review

et al. 2020

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Background: Carotid paragangliomas are rare tumors. They are usually unique, non-secreting, resectable, and benign. However, additional rare cases of complex tumors (bilateral, secretory, nonresectable, or malignant) complicate the management and final outcomes. Methods: Records of paragangliomas from our hospital are reviewed. Criteria defining complex paragangliomas have been previously defined. These are compared with those of the simple group. Results: Fifty patients, two groups: simple (n = 39) and complex (n = 11). The patients in the complex group were significantly younger (47.7 vs 63.8 years). Postoperative nerve complications (45.4% vs 6.3%) and mortality during follow-up (27.3% vs 0%) were significantly more common in the complex group. Vascular complications (0% vs 3.1%) and early mortality (0%) were similarly in both groups. Conclusions: Patients with complex carotid paragangliomas are heterogeneous. The former are younger, exhibit a high degree of diagnostic and therapeutic complexity, and have poorer morbidity and mortality. Surgical experience and interdisciplinary collaboration are essential.

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Head and Neck Paragangliomas: Experience in 126 Patients With 162 Tumours

Cited by 19 publications

References 27 publications

Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment

Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment

Paragangliomas da Cabeça e Pescoço: A Experiência de um Centro Oncológico do Sul da Europa

Simple and complex carotid paragangliomas. Three decades of experience and literature review

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