Head and neck inflammatory myofibroblastic tumor (IMT): Evaluation of clinicopathologic and prognostic features

Ong, Hui Shan; Ji, Tong; Zhang, Chen Ping; Li, Jiang; Wang, Li Zhen; Li, Rong Rong; Sun, Jian; Ma, Chunyue

doi:10.1016/j.oraloncology.2011.09.004

Cited by 65 publications

(73 citation statements)

References 34 publications

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“…The diagnosis is based on histological examinations and is documented by immunodiagnosis and immunohistochemistry [1,2,3,16]. In our case, the cells were positive for SMA, Caldesmon and Calponin while exhibiting inflammatory infiltration, myxoid degeneration and scattered spindle cells as in the second histological type above described.…”

Section: Discussionmentioning

confidence: 48%

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Nikolaou¹,

Sakkas²,

Konstantinos³

et al. 2017

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Introdaction: Inflammatory myofibroblastic tumor [IMT] is a benign pseudoneoplastic proliferation which arises mainly in the lung , but extremely rarely may develop in the larynx. We report a rare case of a laryngeal IMT, mimicking a neoplastic lesion. Material and Method:A 56 years old male patient presented with a history and symptomatology typical for laryngeal carcinoma. The patient reported gradual hoarseness of the voice for 6 months and dyspnoea and stridor after effort. The patient is heavy smoker and a heavy drinker and reported nothing else significant from his medical report. Examination revealed a large mass arising from the right vocal cord, causing significant obstraction of the glottis. Results:The patient underwent microlaryngoscopy for biopsy, but complete excision of the tumor in a single specimen was performed. The intubation, operation and postop period went uneventful. The patient was discharged from the hospital the following day. Histopathologic features of the specimen were diagnostic for inflammatory myofibroblastic tumor. Follow up laryngoscopy after 8 months showed normal findings and the patient is asymptomatic. The patient remains in close follow up. Conclusion:In patients with chronic hoarseness who have a malignant looking laryngeal tumor inflammatory myofibroblastic tumor should be considered. Conservative surgery, with occasionally additional steroid treatment and close follow up of the patient, is recommended.

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Section: Discussionmentioning

confidence: 48%

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Nikolaou¹,

Sakkas²,

Konstantinos³

et al. 2017

JOENTR

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“…Only when radiotherapy was combined with surgery did it seem to show a treatment benefit. Ong et al investigated the use of surgery and radiotherapy in their retrospective analysis of 28 patients with head and neck IMT and found margin status to be the strongest predictor for local recurrence 15. They also used recursive partitioning analysis (RPA) to define three risk groups for recurrence, including factors such as presence of spindle cells, intralesional necrosis, Ki-67 intensity, ALK positivity and margin status.…”

Section: Discussionmentioning

confidence: 99%

Treatment-refractory ALK-positive inflammatory myofibroblastic tumour of the oral cavity

et al. 2018

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We present a challenging case of a previously healthy 23-year-old man who developed an inflammatory myofibroblastic tumour of the hard palate, harbouring a rearrangement of the anaplastic lymphoma kinase (ALK) locus. Despite surgical intervention, radiotherapy and ALK-inhibition therapy, the tumour recurred locally and metastasised to regional lymph nodes, and the patient passed away roughly 9 months after diagnosis from local progression. The rapid progression of this patient's disease and its resistance to treatment demonstrate the potentially aggressive clinical course of inflammatory myofibroblastic tumours. ALK-inhibition therapy was unsuccessful in this ALK-positive tumour, highlighting the need for further investigation of markers predictive of disease progression and treatment response.

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“…Inflammatory myofibroblastic tumour (IMT) is a rare neoplasm which is believed to include less than 1% of soft-tissue sarcomas 1. The tumour that is also called inflammatory pseudotumour (IPT) or plasma cell granuloma occurs most often in children and young adults and predominantly has a benign nature but in some occasions, it can have more aggressive and malignant behaviour 2…”

Section: Introductionmentioning

confidence: 99%

Recurrent inflammatory myofibroblastic tumour of the lung: FDG PET/CT scan findings

et al. 2018

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Inflammatory myofibroblastic tumour (IMT) is a rare neoplasm, occurring most often in children and young adults. IMTs have intermediate biological behaviour with the chance of local invasion, recurrence and even distant metastasis. Wide range of clinical presentations makes the precise diagnosis of IMT more challenging. The best method for definitive diagnosis is tissue biopsy and newer imaging modalities including fleurodeoxyglucose (FDG) positron emission tomography (PET)/CT are useful tools in detection of disease recurrence or distant metastasis. Complete surgical resection is the best-known treatment for this tumour. Here we are presenting an IMT case in a 12-year-old girl in which her recurrent pulmonary IMT was diagnosed based on FDG PET/CT findings and referred for further salvage treatment. Overall imaging modalities are not specific, but PET/CT scan can be useful tool for evaluation of IMT regarding initial staging and restaging to assess treatment response and recurrence.

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Head and neck inflammatory myofibroblastic tumor (IMT): Evaluation of clinicopathologic and prognostic features

Cited by 65 publications

References 34 publications

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Inflammatory Myofibroblastic Tumor of the Larynx: Report of a Rare Case and Literature Review

Treatment-refractory ALK-positive inflammatory myofibroblastic tumour of the oral cavity

Recurrent inflammatory myofibroblastic tumour of the lung: FDG PET/CT scan findings

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