Head and neck cutaneous metastasis of testicular choriocarcinoma

Shabani, Sepehr; Pritchard, Nicholas; Padhya, Tapan; Mifsud, Matthew

doi:10.1136/bcr-2019-233337

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Due to its pronounced invasiveness into blood vessels and tissues, extensive hemorrhage, necrosis, and lymphovascular invasion are common findings ( 67 ). Choriocarcinoma primarily metastasizes hematogenously, resulting in early and extensive dissemination to sites such as the lungs, liver, skin, retroperitoneal lymph nodes, gastrointestinal tract, and central nervous system ( 37 , 68 – 71 ). In this case, the diagnosis of choriocarcinoma was established at an advanced stage, with multiple metastases already present throughout the body.…”

Section: Discussionmentioning

confidence: 99%

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Huang,

Zheng,

Bao

et al. 2024

Front. Med.

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BackgroundNon-gestational choriocarcinoma, also known as primary choriocarcinoma, is extremely rare in men, manifesting with specific signs such as breast feminization, testicular atrophy, and loss of libido. The presentation typically includes elevated serum β-hCG levels, widespread metastatic disease, and a rapid progression of the condition.Case reportWe present a rare case of a 41-year-old man diagnosed with choriocarcinoma, exhibiting a unique combination of multiple metastases, including lung, brain, bone, and retroperitoneal lymph node metastases, as confirmed by 18F-FDG PET/CT imaging. The patient was treated with aggressive chemotherapy and pembrolizumab, and the prognosis remained poor. The patient’s overall survival was a mere 5 months following diagnosis.ConclusionNon-gestational choriocarcinoma represents a rare entity in clinical practice and should be considered in young men presenting with gynaecomastia and elevated β-hCG levels alongside normal gonads. Thus, we advocate for a more comprehensive inquiry into medical history and a systematic examination. The 18F-FDG PET/CT examination not only visually delineates the lesion’s location and extent but also serves as a cornerstone for clinical tumor staging, providing valuable support for treatment monitoring and subsequent follow-up.

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Section: Discussionmentioning

confidence: 99%

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Huang,

Zheng,

Bao

et al. 2024

Front. Med.

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“…Hematogenic spread is characterized by predominant involvement of the lungs, brain, and occasionally liver and retroperitoneal lymph nodes [ 8 ]. There were individual cases of metastatic lesions of the skin [ 9 ] and pancreas [ 10 ]. Metastasis of CC into the stomach is a very rare phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

Подзолков¹,

Pokrovskaya²,

Тарзиманова³

et al. 2021

Case Rep Gastroenterol

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Choriocarcinoma (CC) is a very rare and aggressive neoplasm. The characteristic feature of this disease is a rapid hematogenous spread, mainly to the lungs and brain, which largely defines clinical signs of the disease and complicates the diagnosis. Gastrointestinal metastases are rare, and of those, only few cases with gastric location have been reported. There are publications describing choriocarcinoma syndrome (CCS). As a rule, it presents in patients with an advanced disease and is characterized by hemorrhage from metastatic foci, leading to hemoptysis and gastrointestinal bleeding. CCS development is associated with poor prognosis and high mortality. This article describes a case of testicular CC with rare few gastric metastases, complicated by CCS.

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“…15 Due to its high-vasculature, choriocarcinoma cutaneous metastasis usually manifest as hemorrhagic nodules, red papules resembling hemangiomas, or occasionally as asymptomatic subcutaneous nodules, 16 which can be solitary, as in our case, or multiple. Metastasis to unusual skin sites including nasal skin, 17 the lip, 5 or the little finger 18 are on record. Cutaneous metastasis to the back, similar to our case, has only been reported in another case of a 22 year old male patient, albeit, as multiple nodules, and the patient died 3 months later.…”

Section: Discussionmentioning

confidence: 99%

“… 4 Cutaneous metastatic choriocarcinoma is a rare encounter with a few cases reported in literature. 5 In this case, we present a patient with testicular choriocarcinoma that progressed to develop metastatic cutaneous lesion.…”

Section: Introductionmentioning

confidence: 99%

Choriocarcinoma metastatic to the skin: A rare occurrence associated with dismal outcome

2021

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Germ cell tumors (GCTs) are a histologically heterogeneous group of tumors that arise from the primitive germ cell of the embryonic gonad. Choriocarcinoma is a variant of GCTs that is prone to hematogenous metastasis to the liver, lung, and brain. Cutaneous metastasis in choriocarcinoma is rarely encountered with only a few cases reported in literature. We report the case of a 28-year-old male presenting with lower back pain that, upon further work-up, was diagnosed with pure choriocarcinoma of the testes. Around 9 months after his initial presentation, he developed a cutaneous back lesion. Microscopic examination confirmed the presence of choriocarcinoma composed of mononuclear cytotrophoblasts which interweave with multinucleated syncytiotrophoblasts. The patient passed away 3 weeks after the onset of cutaneous metastasis.

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Head and neck cutaneous metastasis of testicular choriocarcinoma

Cited by 6 publications

References 12 publications

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome

Choriocarcinoma metastatic to the skin: A rare occurrence associated with dismal outcome

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