Head and Neck Cancers in Developing Countries

Joshi, Poonam; Dutta, Sourav; Chaturvedi, Pankaj; Nair, Sudhir

doi:10.5041/rmmj.10143

Cited by 182 publications

(152 citation statements)

References 30 publications

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“…OVC has complex etiology which depends on a variety of factors (15,16). There exist strong associations between OVC and alcohol consumption, smoking, areca nut chewing and oral microbiota (17)(18)(19)(20)(21).…”

Section: Etiologymentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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Abstract. Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.

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Section: Etiologymentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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“…2,3 It is the most common cancer of males and the fifth most common in females. 4 It ranks among the top three types of cancer in the country and accounts for 30%-40% of all the malignant tumors in India. Near about 83,000 new oral cancer cases are registered here and 46,000 deaths occur annually.…”

Section: Introductionmentioning

confidence: 99%

Abrus agglutinin targets cancer stem-like cells by eliminating self-renewal capacity accompanied with apoptosis in oral squamous cell carcinoma

et al. 2017

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The accumulating evidences show that Abrus agglutinin, a plant lectin, displays a broad range of anticancer activity including cancer-specific induction of apoptosis; however, the underlying molecular mechanism of Abrus agglutinin-induced oral cancer stem cell elimination remains elusive. Our data documented that Abrus agglutinin effectively downregulated the CD44 + expression with the increased CD44 − population in different oral cancer cells. After 24-h Abrus agglutinin treatment, FaDu cells were quantified for orosphere formation in ultra-low attachment plates and data showed that Abrus agglutinin inhibited the number and size of orosphere in a dose-dependent manner in FaDu cells. Furthermore, Abrus agglutinin hindered the plasticity of FaDu orospheres as supported by reduced sphere formation and downregulated the self-renewal property via inhibition of Wnt-β-catenin signaling pathway. Introduction of LiCl, a glycogen synthase kinase 3β inhibitor, rescued the Abrus agglutinin-stimulated inhibition of β-catenin and phosphorylated glycogen synthase kinase 3β in FaDu cell-derived orospheres confirming importance of Wnt signaling in Abrus agglutinin-mediated inhibition of stemness. In this connection, our data showed that Abrus agglutinin restrained proliferation and induced apoptosis in FaDu-derived cancer stem cells in dose-dependent manner. Moreover, western blot data demonstrated that Abrus agglutinin increased the Bax/Bcl-2 ratio with activation of poly(adenosine diphosphate-ribose) polymerase and caspase-3 favoring apoptosis induction in orospheres. Abrus agglutinin induced reactive oxygen species accumulation in orospheres and pretreatment of N-acetyl cysteine, and a reactive oxygen species scavenger inhibited Abrus agglutinin-mediated caspase-3 activity and β-catenin expression indicating reactive oxygen species as a principal regulator of Wnt signaling and apoptosis. In conclusion, Abrus agglutinin has a potential role as an integrative therapeutic approach for combating oral cancer through targeting self-renewability of orospheres via reactive oxygen species-mediated apoptosis.

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“…Majority of the Indian patients with ADCs or NADCs were males 6 in previous studies, but in our study majority 61% of the patients were females (115/189). The ADCs were more common in a previous study 7 done on South Indian patients. But in our study, the ADCs were seen in 47.6% (90/189) and NADCs were seen in 52.38% (99/189) of patients.…”

Section: Resultsmentioning

confidence: 94%

“…This is due to the use of oral tobacco and betel nut and areca nut. 7 Similarly, penile cancers are seen more frequently among Indian population than described in the west. 8,9 The spectrum of cancers among Indian HIV patients include common malignancies or those related to HPV infection like that seen in the west.…”

Section: Resultsmentioning

confidence: 99%

Cancer in Human Immunodeficiency Virus Patients- A Study From a Regional Cancer Centre

Suryadevara¹,

Chinta²,

Putcha³

2017

jemds

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BACKGROUNDPatients with Human Immunodeficiency Virus (HIV) are at higher risk for cancers, either Acquired Immunodeficiency Syndrome (AIDS) defining cancers (ADCs) or non-AIDS defining cancers (NADCs). The pattern of HIV and malignancy is different among the Indian population and the literature on this topic is sparse.The aim of this study is to evaluate the pattern and spectrum of malignancies in HIV positive patients at our institute. MATERIALS AND METHODSThis is a Descriptive Study. A total of 15,964 patients were screened and of these 240 were positive for HIV (1.5%). These patients were reviewed for demographics and type of malignancy. RESULTSThe median age was 40 years for both males and females. Majority were females (61%). Most common malignancy in males was head and neck cancer (HNNC) followed by non-Hodgkin's lymphoma (NHL), carcinoma penis, rectum and anal cancers. In females, most common malignancy was carcinoma cervix followed by carcinoma breast and HNNC, NHL and thyroid cancer. Overall, most common malignancies in HIV positive were carcinoma cervix (39%), HNNC (16%), carcinoma breast (7.4%), carcinoma penis (6%) and anal canal and rectum cancer (6%).

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Head and Neck Cancers in Developing Countries

Cited by 182 publications

References 30 publications

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Abrus agglutinin targets cancer stem-like cells by eliminating self-renewal capacity accompanied with apoptosis in oral squamous cell carcinoma

Cancer in Human Immunodeficiency Virus Patients- A Study From a Regional Cancer Centre

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