Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018)

Creaney, Grant; McMahon, Alex D.; Ross, Alastair; Bhatti, Lesley A.; Paterson, C.; Conway, David I.

doi:10.1038/s41415-022-5151-4

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…In Japan, the incidence of oropharyngeal, oral cavity, and salivary gland tumors has gone up, more for women than men, while nasopharyngeal and laryngeal tumor incidence has gone down (which are more associated with the Epstein–Barr virus in East Asian populations than with HPV) [ 8 ]. Likewise, in the UK, oropharyngeal HNSCC has increased by 7.3% among men and 6.5% among women, and oral cancer has increased by 2.8% and 3.0% for men and women, respectively, with the greatest growth seen in those of lower socioeconomic status [ Figure 3 ] [ 9 , 10 ].…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma

Barsouk

Aluru

Rawla³

et al. 2023

Medical Sciences

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Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies, involving the oral cavity, pharynx, hypopharynx, larynx, nasal cavity, and salivary glands, that together compose the seventh most common cancer diagnosis worldwide. With 890,000 new cases and 450,000 deaths annually per GLOBOCAN estimates, HNSCC accounts for roughly 4.5% of cancer diagnoses and deaths. In the developing world, the incidence of HNSCC is growing with increasing consumption of tobacco (smoked or chewed), alcohol, and areca nut (betel quid). Alcohol and tobacco have a synergistic effect, with the heavy consumption of both increasing HNSCC risk 40-fold. In developed nations, HPV-related HNSCC surpasses tobacco- and alcohol-related disease. HPV-related HNSCC more commonly affects the oropharynx, hypopharynx, and larynx than the oral cavity, and is associated with a significantly longer median survival (130 months vs. 20 months). Discrepancies in etiology as well as disparities in lifestyle choices and access to healthcare may account for the greater incidence and poorer survival of HNSCC among minority and lower-socioeconomic-status communities in developed nations. Pharmacotherapy and counseling together have been shown to be effective in promoting smoking and alcohol cessation. Education on cancer risk and community engagement have reduced areca nut consumption in Asia as well as in diaspora communities. HPV vaccination, starting at age 11–12 for both sexes, has been shown to reduce the prevalence of high-risk HPV serologies and prevent pre-cancerous lesions of the cervix, vagina, and vulva. As of 2020, 58.6% of eligible adolescents in the US have received the full two-vaccine series. Increased adoption of vaccination, education on safe sex practices, and routine visual oral screening for high-risk patients would curb growing HNSCC incidence in developed nations.

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Section: Epidemiologymentioning

confidence: 99%

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma

Barsouk

Aluru

Rawla³

et al. 2023

Medical Sciences

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“…Although the information on cancer upstaging due to the pandemic effect is of paramount clinical importance, data on the transformation of the cancer stage caused by the pandemic are scarce. The present study is the first documented study focused on the head and neck cancers stage with considering the TNM staging, 19 however, it is associated with a few limitations.…”

Section: Discussionmentioning

confidence: 96%

The stage of head and neck diagnosed malignancies in COVID‐19 outbreak versus before outbreak: A retrospective study

2023

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Background Global COVID‐19 pandemic has affected cancer care systems. Recent studies show that the number of cases diagnosed with cancer has drastically decreased compared to the same period before the pandemic. Therefore, we are confronted with delayed diagnosis of critical cancers. Aim The aim of this study is to investigate whether the stage of known cancers has been affected by delayed diagnosis and to compare the stages of head and neck cancers diagnosed during and before the pandemic. Methods The present study was conducted on 132 patients with malignant head and neck tumors referred to the otolaryngology, head and neck cancer department of Taleghani Hospital from 2019 to 2021. The stage of cancers was compared between two groups of patients with head and neck malignancy referred to the Otolaryngology, Head and Neck Department of the Taleghani Hospital before and during the COVID‐19 outbreak. Results The results from tumor (T), nodes (N), and metastases (M) (TNM) staging ( p ‐value = .015) and T score (value = 0.045) showed that the stage of tumor diagnosed in patients during the COVID‐19 pandemic significantly increased compared to patients diagnosed with a tumor before pandemic. Conclusion In the present study, it was observed that the early symptoms of malignant head and neck tumors have been neglected by patients during COVID‐19 pandemic and resulted in delayed diagnosis. This result may be explained by the fear of COVID‐19 infection in patients, which discouraged them from visiting a doctor at healthcare centers.

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“…Laryngeal carcinoma is the 3rd most common head and neck cancer (1). A signi cant proportion of laryngeal carcinoma patients present with advanced staged cancer (2). Curative treatment options of advanced laryngeal carcinoma include surgery, (chemo)radiotherapy, or a combination of both.…”

Section: Introduction Background/rationalementioning

confidence: 99%

A Retrospective Review of Dissection Type and Outcomes in Advanced Glottic Carcinoma

Soon,

Habib,

Wong

et al. 2024

Preprint

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Intro: Neck dissection is performed in the management of advanced laryngeal carcinoma due to the risk of metastases to cervical lymphatics. Current NCCN Guidelines and UK guidelines offer differing advice on glottic carcinoma, with NCCN recommending ipsilateral and/or bilateral dissection and UK recommending bilateral dissection. This paper aims to assess the outcomes of unilateral and bilateral neck dissection in surgically managed advanced glottic carcinoma. Method: Retrospective review of twenty-four patients with advanced glottic carcinoma (T3-4, N-N2b) from the years 2014-2020 who had as primary surgical treatment. Survival analysis, cox regression and fisher exact test were performed. Results: We found no statistically significant difference in 5-year overall survival and local recurrence between unilateral neck (ULN) dissection and bilateral neck dissection (BLN). Conclusion: While the data from this study shows no statistical significance between dissection type and survival, we suggest that ULN, based on published literature provides an equivalent survival outcome with a lower complication rate.

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Head and neck cancer in the UK: what was the stage before COVID-19? UK cancer registries analysis (2011-2018)

Cited by 10 publications

References 31 publications

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma

The stage of head and neck diagnosed malignancies in COVID‐19 outbreak versus before outbreak: A retrospective study

A Retrospective Review of Dissection Type and Outcomes in Advanced Glottic Carcinoma

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